I don't have tons of knowledge about pumpkin seed but, based on some of the articles I've read, they can cause some major sickness in some people with parasites. I don't know if the sickness results from die-off or the pumpkin seed themselves, though. That's really all I can offer. I hope some of the more knowledgeable people decide to share some information. I, too, am very interested in finding out more about pumpkin seed.