My big warts were itching like crazy and I had several small ones. It took all the small warts off and I've had no further problems with them. I had to take bloodroot internally to stop the big ones from itching. I guess it depends on how long you've had it and how deep they go. I agree with the lady who wrote the book Cancer Salves. She says you need to cleanse internally. If I could do it over, I'd start by cleasning my system and taking it internally for a while.