Yes, I do supplement with a probiotic with my Oxypowder . I have a pleura of suggestions that I could suggest in addition to intestinal cleansing. I try not to overwhelm people with this knowledge.I have found that if you suggest several things. People find that cleansing is too overwhelming and this discourages them. I will suggest multiple things if the person is open to a more extensive cleansing protocol. However, I actually use Kefir and drink it every day. I have looked at the Syntol and this one probiotic looks like a good one. If I were to use a probiotic supplement, I have found thru my extensive research that you should use a probiotic that is spore bearing. The Syntol also contains digestive enzymes which those of us that have digestive issues our bodies do not produce enough of.