If P-5-P form of B-6 helps with Carpal Tunnel...

This info is from Dr. Larrian Gillespie's wonderful website: http://menopausediet.com/Store/p5p.htm

PYRIDOXAL 5 PHOSPHATE
In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. The active form of Vitamin B-6 is Pyridoxal-5-phosphate or P5P, this active form allows for the best absorption, because it is ready to go to work immediately.

It is primarily in the liver that P5P is synthesized from pyridoxine with the help of enzymes this requires Vitamin B2, zinc and magnesium for their activity. P5P is associated with numerous enzymes, many of which are involved in amino acid metabolism. This necessary process produces the neurotransmitters dopamine, nor adrenalin, GABA and cartooning, as well as the hemoglobin in red blood cells.

Many B6 supplements are the inactive pyridoxine HCL form. In some cases supplementation of this form singularly, caused a reversible numbness & tingling of the extremities. In doses as low as 200 mg daily over a 3-year period. This problem was thought to be secondary to the liver's inability to convert this form into the useable P5P form. Using P5P avoids this problem.

It's the P5P our bodies really need to break down and use fats, proteins, and carbohydrates, to make red blood cells and antibodies, to help the digestive and nervous systems function, and to maintain healthy skin. But some folks have trouble-converting pyridoxine into P5P. Those susceptible to a deficiency include some breast-fed infants, elderly persons on a poor diet, and women on estrogen-containing oral contraceptive pills. B6 has recently been found to benefit the autistic and is thought the P5P form may even provide more benefit.

Also, people such as: pregnant and nursing mothers, the elderly, the autistic, and babies at risk of SIDS (Sudden Infant Death Syndrome). P5P is the only form of B6 that the fetus and newborn baby can use. In premature babies, who are more susceptible than full-term babies to SIDS, the use of the pyridoxine form of B6 can result in irreversible central nervous system damage. And lack of P5P can predispose a surviving premature infant to atherosclerosis in later life. In addition, the fact that B6 benefits some persons with Carpal Tunnel Syndrome, and not others, we think may well be traced to the person's ability or inability to make P5P from pyridoxine.

SYMPTOMS OF DEFICIENCY:

Depression
Nervousness
Irritability
Slow learning
Poor dream recall
Dizziness
Fatigue
Cracks around mouth & eyes
Dermatitis & acne
Inflamed eyes
Facial oiliness
Stillbirths from deficiency during pregnancy
Decreased lymphocytes
Decreased vitamin C levels
PMS
Increased sensitivity to sound
Water retention
Decreased resistance to infection
Impaired wound healing
Poor appetite
AM nausea/vomiting
Dental cavities
Hair loss
Impaired calcium utilization
Decreased absorption of copper
Decreased iron status
Decreased Vitamin B 12 absorption
Arthritis
Muscular weakness
Neuritis
Carpal tunnel syndrome
Temporary limb paralysis
Numbness & tingling in the limbs
Anemia
Elevated homocysteine levels
Seizures
Low blood sugar
Low glucose tolerance
Abdominal pain

PYRIDOXAL-5-PHOSPHATE BENEFITS INCLUDE:

Helping to relieve premenstrual syndrome.
Useful with carpal-tunnel syndrome.
Helps boost immunity.
Is protective against atherosclerosis.
May be protective against forms of cancer.

Each tablet contains:
Pyridoxal-5-Phosphate 20mg (enteric coated)
All supplements are 100% natural and free of yeast, corn, sugar, starch, soy, flavors, colors, wheat or milk derivatives. preservatives . B6 or pyridoxine is essential for the metabolism of protein as it helps to convert glycogen into glucose which can be used by your muscles for energy. It's an important co-factor in the regulation of 26 aminotransferases, enzymes that regulate the proper pathways for our neuroendocrine system. If you are deficient in B6, you may form kidney stones when you eat sugars such as fructose or galactose. Women need higher doses of B6 than men because we lose more B6 in our urine. Women taking birth control pills to control menopausal excess bleeding can become depleted of B6, which results in disturbances in the metabolism of tryptophan. This can cause depression, anxiety, decreased sex drive and impaired glucose tolerance. B6 is important in lowering homocysteine levels in blood. Pyridoxal-5-phosphate, the liver metabolized form of B6, is the active component. However, if you have problems with gastric emptying, you may not be able to absorb B6 from standard vitamins unless it has been treated for absorption in the small intestine or duodenum.

1 bottle 100 enteric coated tablets - $29.95

BENEFITS FOR CARPAL TUNNEL SYNDROME:

In many cases, carpal tunnel syndrome (CTS) is thought to result from long-term repetitive motions of the hands and wrists, such as from typing. Although repetitive motion is often a culprit, it does not explain the frequent occurrence of CTS with non-motion-related conditions, such as pregnancy. Conventional treatment includes splinting, rest, anti-inflammatory drugs, and frequently, surgery, which relieves pressure and eliminates the symptoms.

Nutritional supplements that may be helpful: Vitamin B6 is the most frequently used and well-known nutritional treatment for CTS. It appears that many people with CTS have vitamin B6 deficiencies. Some studies show that people with CTS are helped when given 100 mg of vitamin B6 three times per day. Although some researchers have found benefits with lesser amounts, the results have not been consistent. Often, CTS will improve in two to three months with vitamin B6 supplementation.

In order to be effective, vitamin B6 must be transformed in the body to pyridoxal-5'-phosphate. Some doctors of natural medicine suggest that people who do not respond well to the vitamin B6 supplements try 50 mg of pyridoxal-5'-phosphate three times per day.

Are there any side effects or interactions? Although side effects from vitamin B6 supplements are rare, at very high levels this vitamin can damage sensory nerves, leading to numbness in the extremities as well as difficulty walking. Vitamin B6 supplementation should be stopped if these symptoms develop.

Note: Pregnant and lactating women should not take more than 100 mg of vitamin B6 per day, or 75 mg of P5P. Consult your health care professional before using this product.

Pyridoxal-5-Phosphate is somewhat humidity sensitive. It should be kept out of the sun, in a cool, dry place. Do not refrigerate! Keep out of the reach of children.
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