Think you hit something here.... My Ma has bursitis and can be agrevated by a leaky gut, which she has. We take CoQ10 but will boost the dosage. I know there are 435 identified enzymes and we don't get many if any in our foods any more, so enzymes are critical for the gut. Read many years ago, that people are wasting there time with massive Vitamins and minerals if they don't have enzymes to get them started. Thanks again. PT