Diindolylmethane (DIM) treatment for HPV Infection

Link for article on Diindolylmethane (DIM) treatment for HPV Infection:


http://www.dimfaq.com/site/HPV.htm


DIM can be purchased at any health store! Article below:

DIM Inhibits Human Papilloma Virus (HPV) Growth

Absorption-enhanced 3,3’-Diindolylmethane: Human Use in HPV-related, Benign and Pre-cancerous Conditions.

Zeligs, M.A., Sepkovic, D.W., Manrique, C., Macsalka, M., Williams, D.E.,and Bradlow, H.L

Proc. Am. Assoc. Cancer Res. 2003, Apr; 44.

3,3-Diindolylmethane is a dietary indole from cruciferous vegetables that has demonstrated pre-clinical therapeutic efficacy in models of DMBA-induced mammary cancer, transplanted human breast cancer, and in models of human papilloma virus (HPV) related disease.

Animal and human use of crystalline diindolylmethane has revealed the need for absorption-enhancing technology to allow adequate gastro-intestinal uptake. BioResponse-DIM, a patented formulation of diindolylmethane categorized and sold as a dietary supplement, utilizes solubility-enhancing micro-encapsulation technology to allow absorption of effective amounts of diindolylmethane.

Human use of this formulation promotes a dose-responsive upward effect on the urinary ratio of 2-OH/16-OH estrone metabolites, demonstrated by ELISA testing of urine before-and-after use. In previous prospective studies, a greater 2-OH/16-OH estrone urinary ratio has been associated with a lowered risk of future breast cancer. We are able to monitor compliance by measurement of urinary diindolylmethane using gas chromatography-mass spectrometry.

Human use of this preparation at higher doses has demonstrated treatment-related resolution of moderate and severe cervical dysplasia in preliminary open-label testing. A still higher dose, about 10 times above that possible from dietary exposure to diindolylmethane from vegetable sources, has resulted in the control of laryngeal papillomas and resolution of cutaneous and plantar warts in preliminary human testing. The clearing of HPV-related lesions is consistent with diindolylmethane's previously described, apoptosis-promoting and chemopreventive activity.




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