I used to take primal defense but it never helped me the same as other standard probiotics like acidophilus and bifidus etc. In fact it took me a while to figure out it was primal defense that was making me even more sick. When ever I started taking it, it was about a week after I started getting flu symptoms. I never figured it was primal defense. Then I stopped and started taking it again when id felt better and I got a really bad flu. I never had it so bad in my life. I had to take a bath to stop me from throwing up. Eventually only zapping helped cure me of this. Then I took it again when in Australia and I got sick immediately. I had bought 2 jars of the stuff by then. I then did some research on primald defense and found out that soil based organisms are really tough are not meant for humans to ingest orally. I don't know whether this is true, but all i can say is never underestimate healthy foods as being suspect.