Seen this posted on another site good reading wish I new where it came from?

Denali Green™

Product Summary

By A. True Ott, PhD

Fields of knowledge, especially in the arena of health and nutrition, often revolve in a circle – with scientific "breakthroughs" merely echoing what healers and physicians had discovered and utilized thousands of years earlier. Such is apparently the case with a remarkable product named Denali Green™, distributed exclusively by a direct marketing company named Denali Health Sciences.



Denali Green™ is purely natural, non-chemical nutritional supplement that is comprised of a proprietary, patent-pending blend of humic acid, fulvic acid, and a volcanic, igneous mineral compound named zeolite. To fully understand the incredible potential of Denali Green™ as a healing and anti-aging supplement, one must learn and understand that over 8 years of research has been conducted on the various component elements of Denali Green™. This summary will explain in detail the truths uncovered by competent research teams.



In addition, this paper has been compiled for yet another purpose: to demonstrate that the potential health benefits outlined herein are based on dozens of very expensive clinical trials, combined with the experience of more than eight years of human consumption. Any claims theorized by DHS concerning Denali Green™ is based on these clinical trials, and is simply not based on gossip, well-intentioned beliefs, or even anecdotal evidence.

WHAT EXACTLY ARE HUMIC AND FULVIC ACIDS?

Humic and fulvic acids are organic compounds of carbon, (also called humin substances) that are found in the natural environment of planet earth. Specifically, "humin substances" are the factors that define "fertility" in farming soils, and also include humus and phenolic acid. Humin substances are the residue of plant (and to some degree animal) fibers rich in carbon that have decomposed in concentrated layers over the millennia. The richest sources of humin substances are the peat bogs of Europe, which contain the residue of plants that lived 6,000-10,000 years ago. It is also interesting to note the base root of the word "humin" in the original Greek texts refers to the earth itself – as does the related word "human" meaning being formed of the earth itself. (The Genesis account in the bible refers to man being formed from the "dust of the earth" – or in the Greek text – the HUMIN of the earth.)

The organic chemistry definition of the two substances is as follows:

Humic Acid: A humic substance that is not soluble in water under low pH conditions (acidic conditions), but becomes soluble in an alkaline pH environment. Humic acids have medium molecular size, with a molecular weight between 50,000 and 100,000 dalton on average. Oxygen molecules compose 36% of humic acid, while nitrogen content is 4%. Because of its specific molecular structure, humic acid is a powerful electron donor, carrying a large negative surplus electrical charge on its surface. This release of electrons allows increased energy release on the cellular level of seeds and plant roots, resulting in rich and abundant plant growth.

Fulvic Acid: A humic substance that is water soluble under all pH conditions. Fulvic acid have the lowest molecular size and weight of all humic substances, with a molecular weight of only 2000 dalton. Oxygen content is very high at 48%, with nitrogen content below 4%. When combined with humic acid, the combined surface negative electron charge is compounded, causing significant energy production.

Studies have found that humic and fulvic acid compounds are essential in providing ENERGY to the cells (either plant or animal). This organic energy in turn allows the cells to process and utilize specific mineral ions to produce critical amino acid chains, proteins, and hormone chemicals. Scientific laboratory testing has also documented that human supplementation of humic and fulvic acids in a pH neutral, water-soluble form provides two very essential therapeutic benefits: A) increases the absorption of vital trace element and minerals on the cellular level, and B) their innate capacity to bind with toxic heavy metals such as lead, cadmium and mercury and remove them from the organism effectively.

Combining with iron molecules in the blood, humic and fulvic acid molecules increase the oxygen-carrying capacity of the blood, thereby increasing the cellular respiration factors and the all-important production of the cellular energy factor – adenison tri-phosphate (or ATP). In short, cells that are able to produce energy with EASE are LIVING CELLS, and thus it is much harder for Dis-EASE states to exist in the cells, organs, or tissues of the body.

Let’s look closer at these humin substances and explain the metabolic process in depth.

HUMIC/FULVIC ACID METABOLIC EFFECTS

Studies involving rats have demonstrated that the liver is the organ in which humic acid is first absorbed and then broken down into its primary elements. The breakdown of humic acid, to a lesser degree, also occurs in the gut, as beneficial, aerobic bacteria utilize the carbon in humic acid as fuel.i[1] This is a very small fraction, however, as additional studies have shown that only 0.1% of humic acid is absorbed in the intestinal tract.ii[2]
Once absorbed into the liver, humic acid components have shown the ability to substantially accelerate cell metabolism – specifically the breakdown of glucose simple sugars, leucine and uridine. Humic acid supplementation regulates the rate of incorporation of these organic molecules into the liver – but amazingly, once the sugars are absorbed, humic acid accelerates their metabolism into energy (i.e. electron-releasing compounds such as ATP.)iii[3]

In the same study, the presence of humic acid in the liver increased and greatly enhanced the utilization of mineral nutrients. Specifically, the increased amount of molecular transfer across the intestinal cellular membrane was: Calcium and Magnesium (the alkalizing elements) 50%, Sodium and Potassium 16%, and heavier metals such as Manganese, Iron, and Zinc absorption was increased by an incredible 80%. iv[4]

In other studies, humic acid supplementation substantially increased the efficiency of the liver cell mitochondria by markedly increasing the respiratory rates.v[5] As mentioned earlier in this paper, increasing cellular respiration rates can only occur in the presence of increased oxygen levels and the absorption of key mineral elements. Once cellular respiration is increased, however, the result is the more effective production of ENERGY in the form of ATP at the cellular level.vi[6] The increased cellular ENERGY then results in increased energy levels of the organism as a whole – energy that can be used to overcome a dis-ease condition caused by bacterial or viral infection, parasite or fungal infestation, toxic environment, and even emotional stress. In short, in the critical area of cellular respiration and metabolism, humic/fulvic acid supplementation may be one of the smartest, health-promoting ideas of the century.

HUMIC/FULVIC ACID HEAVY METAL REMOVAL

It appears that the cationic electron exchange ability, combined with the ligand formation ability (binding capacity) of humic and fulvic acid can help explain why they are able to increase the absorbability of certain "healthy" metallic molecules such as potassium, calcium, and magnesium, while binding with "harmful" elements such as lead, cadmium, and mercury eventually eliminating the metals from the cells and tissue. Removing these toxins from the body is a very important key to health and wellness in today’s world.

Cadmium, lead, and mercury are bivalent ions and are extremely toxic environmental poisons primarily because they interfere with key cellular respiration mechanisms. Cadmium is documented as being a central nervous system neurotoxin, and thanks to modern fertilizing and insecticide chemicals, food in the United States has high levels – as much as 25 to 60 mcg is ingested daily in the average American diet.vii[7] Without natural chelation provided by humic/fulvic acids, cadmium accumulates in the body tissues. Elevated cadmium levels have been linked to renal (kidney) failure and disease,viii[8] hypertension, hepatic injury and lung damage.ix[9] Cadmium also has been shown to bind the transport proteins to absorb minerals as it displaces the ability of copper and zinc to be utilized effectively in the body.x[10]

The nervous system of newborns and toddlers is highly sensitive to lead exposure, leading to many neurological disorders including seizures and brain damage. In adults, lead exposure has been definitely linked to hypertension (elevated blood pressure) especially in males age 40 – 59 years of age. Lead has been found in many chemically-processed spices and seasonings.xi[11] Mercury, like cadmium, is a neurotoxin that has been linked to many central nervous system disorders including Parkinson’s disease, Alzheimer’s, ADD and ADHD in children, and many clinical Depression states. Ocean fish such as tuna have ever-increasing levels of these heavy metals due to the dumping of sewage chemicals that in time are absorbed by plankton and are eventually absorbed up the food chain. Additionally, mercury Amalgam is used as fillings for dental cavities, as well as a toxic additive to juvenile immunization injections. So, if you feel that a detoxifying supplement such as Denali Green™ is not needed to keep you in peak condition, you had better re-evaluate.



DESMUTAGENIC EFFECTS OF FULVIC/HUMIC ACID

The term mutagenesis refers to the beginning, or genesis, of cellular mutations that eventually form a wide variety of cancerous tumors in the tissues, bones, and organs of the human body. A key factor in the mutagenesis process is the disruption of cellular respiration whereby the cellular terrain becomes acidic. The role humin substances perform in accelerating cellular respiration has been discovered by research. Other mutagenic substances include chemical "medicines", pesticides, ionising radiation and ultraviolet light. Studies have shown that certain natural plant-derived materials such as humic/fulvic acids have been scientifically classified as desmutagens, meaning that they have proven the ability to either react with or bind to specific mutagens to break them down to the point where they become neutralized, thereby providing a strong defense against mutagenesis, and therein, against cancer.xii[12]



Research suggests that the desmutagenic activity of humic/fulvic acids is accomplished by actually ABSORBING mutagens rather than by decomposing them.xiii[13] The absorption of the mutagens happens by means of the formation of specific humic acid-mutagen complexes which subsequently perform extracellularly by eliminating the formation of genotoxic compounds that negatively affect the DNA of the cell resulting in cancer cells.xiv[14] Humic/fulvic acids work as a mutagenic neutralizer outside the cell, rather than the direct protection of the DNA from damage at the intracellular level. Furthermore, it appears that the mechanism of the action of humic/fulvic acids is not directly inhibiting the metabolism of the mutagen itself, but rather the acid is actually binding to and completely inactivating the mutagen. The ability of humic/fulvic acid to absorb mutagens has been shown to increase with the molecular weight of the acid.xv[15]



ROLE OF HUMIC/FULVIC ACID IN CARDIOVASCULAR HEALTH

Despite decades of research into the factors contributing to cardiovascular disease, it is still the leading cause of premature death in North America with nearly a million deaths a year in the United States alone. It is estimated that there are over 30 million Americans suffering from heart diseasexvi[16] with untold millions of Americans exhibiting high risk attributes such as obesity, high blood pressure, diabetes, smoking, and diets high in free radical content.



Heart attacks generally occur when the heart valves and arteries constrict and narrow while the blood thickens and clots. The heart organ is essentially a muscle, and when blood flow and the oxygen it carries is restricted to any muscle, even for a short time, tissue destruction and damage is often the result. To greatly reduce the risk of a heart attack, or developing arrhythmia and heart disease, free radicals must be limited by natural antioxidants, and the blood should be enriched with oxygen molecules. Studies have documented that humic/fulvic acid combined with specific minerals such as potassium and calcium may scavenge free radicals, thereby decreasing blood-clotting activity and significantly lowering the risk of heart attack or stroke.xvii[17] xviii[18] Therefore, daily supplementation of Denali Green™ with the potent mineral blend of Denali Gold may be the smartest choice for keeping the all-important heart muscle healthy and vibrant.



In one specific experiment, rats who were subjected to chemically-induced heart attacks (ischaemic insult), the administration of standardized humic and fulvic acids manifested beneficial results. The coronary blood flow, aortic blood flow and left ventricular and diastolic pressure were significantly improved in the hearts of the affected rats. xix[19] Further studies concluded that humic acid has proven value as a cardioprotective agent because of the marked anti-coagulant effect it exhibits.xx[20]



It is theorized that these favourable biological actions of humic/fulvic acid occur because of its complex chemical structure, consisting of numerous structured phenol and quinine rings which are held together by means of something called epsilon donor acceptor complexes (EDACs).xxi[21] Simply stated, EDACs contain specialized molecules that have excessive electrons to donate, AS WELL AS MOLECULAR OXYGEN to donate to the blood and tissue cells when they are found to be deficient. Oxygen and hydrogen free radicals are formed in the blood and tissue when electrons and nutrients are transferred and exchanged through cellular respiration. EDACs exhibit a specific chemical structure that produces "free" electrons that in turn provide covalent hydrogen and oxygen bonds that have been shown to stabilize and then neutralize the free radical moleculexxii[22] as well as inorganic heavy metals, compounds, viruses and mutagens as stated earlier in this paper. It can therefore be concluded that humic/fulvic acids in fact interact synergistically with a wide variety of substances in the human environmental terrain; substances such as carbohydrates, proteins, amino acids, phenols, enzymes, and minerals, while helping to neutralize and eliminate the harmful effects of toxins such as free radicals, viruses, and cancer-causing mutagens. Clearly, the role that humic/fulvic acids play in the stimulation and modulation of the human biochemical functions can not be overstated.



THE ROLE OF ZEOLITE

Zeolite is the name given to natural as well as synthetic micro porous crystals composed primarily of aluminium oxide (AlO4) and silicon oxide (SiO4) that are bound to hydrogen and oxygen ions in a tetrahedron geometrical pattern. For many decades, zeolite has been extensively used in industrial applications, because of their ability to act as catalysts for specific chemical reactions, ion exchangers, absorbents, and cleaning/deodorizing agents. Many people are unaware; however, that zeolite has been clinically tested and found to be an excess glucose absorbent which may be helpful in reducing the symptoms of diabetes mellitus.xxiii[23] Zeolite is the principal element in the prescription anti-diarrheal drug Enterex largely because extensive lab testing proved the effectiveness of zeolite in combating intestinal disease conditions.xxiv[24] However, the most exciting lab tests have revealed that zeolite and its aluminosilicate structure plays a vital role in strengthening the immune system. Specifically, testing performed by Ueki et.al.xxv[25] and Aikoh et alxxvi[26] discovered that silica, silicates and aluminosilicates such as zeolite act as non-specific immuno-stimulators in a very similar manner as "superantigens" but without the potentially harmful side-effects. (Superantigens are a specific class of immunostimilatory, yet disease-causing proteins of bacterial and viral origin that have shown the ability to activate relatively large portions (up to 20%) of the body’s T-Cell population.) Thus, zeolite may well help to stimulate the immune system to help fight chronic, infectious disease states.



When combined with the complex chemical structure of humic/fulvic acid, zeolite with its ion-exchanging capacity likely acts as an adjuvant (or multiplier) of both supplements’ beneficial qualities.



This may help to explain the reasons behind the many incredible testimonials realized on the Denali Green™ product.




REFERENCES



i[1] Frimmel, F.H. and R.F. Christman, eds. Humin Substances and Their Role in the Environment. 1st ed. Vol. 1. 1988. Wiley-Interscience Publication: New York.

ii[2] Lind, Y. and A.W. Glynn, The Influence of Humic Substances on the Absorption and Distribution of Cadmium on Mice. Pharmacology and Toxicology, 1999. 84: p. 267-273

iii[3] Visser, S.A. some Biological Effects of Humic Acids in the Rat. Acta Biologica Et Medica Germanica, 1973. 31: p. 569-581

iv[4] Ibid: p 583

v[5] Visser, S.A. Effect of Humic Substances on Mitochondrial Respiration and Oxidative Phosphorylation. The Science of the Total Environment. 1987, 62: p. 347-354.

vi[6] Principles of BioChemistry. 2nd edition., A. Lehninger, D. Nelson, and M. Cox. 1993, New York, Worth Publishers.

vii[7] Shils, O., and Shike, ed. Modern Nutrition in Health and Disease, 8th Ed., Vol. 2. 1994, Williams and Wilkin: Baltimore.

viii[8] Ibid

ix[9] Hudak, A., et al., Effect of the consumption of humic acid with bound complex micro elements in cases of occupational cadmium exposure. Central European Journal of Occupational and Environmental Medicine, 1997. 3(3): p. 175-186.

x[10] Shauss, A., Minerals, Trace Elements, and Human Health. 3rd Ed. 1998, Tacoma: AIBR Press

xi[11] Szekely, I., Lead Poisoning Caused by Adulterated Paprika. 1994, Szt. Gyorgy Hospital: Szekesfehervar (unpublished clinical

xii[12] Shankel, D.M., et al., Extracellular Interception of Mutagens. Basic Life Science, 1993. 61: p. 65-74.

xiii[13] Sato, Tl, et al., Adsorption of mutagens by humic acid. The Science of the Total Environment, 1987, 62: p. 305-310.

xiv[14] Mineralab, Il, A Clinician’s Guide to Toxic Metals, 1979: Hayward.

xv[15] Sato, Tl, et al., Adsorption of mutagens by humic acid. The Science of the Total Environment, 1987, 62: p. 305-310

xvi[16] Report, Centers for Disease Control, 2005

xvii[17] Ferdinandy, P. Cardioprotective effects of Humic and Fulvic acid preparations in the isolated working rat heart subjected to eischaemia/reperfusion, 1997 (unpublished).

xviii[18] Klocking, H. P., Influence of natural humic acids and synthetic phenolic polymers on haemostasis. Archives of Toxicology, 1991, suppl 14:p 166-169

xix[19] Ferdinandy, P. Cardioprotective effects of Humic and Fulvic acid preparations in the isolated working rat heart subjected to eischaemia/reperfusion, 1997 (unpublished).

xx[20] Klocking, H. P., Influence of natural humic acids and synthetic phenolic polymers on haemostasis. Archives of Toxicology, 1991, suppl 14:p 166-169

xxi[21] Riede, U.N. et al., Humate-induced activation of human granulocytes. Virchows Archiv B Cell Pathol, 1991, 60: p. 27-34.

xxii[22] Humin Product Documentation and Technical Information. Horizon Multiplan LTD, Budapest 1999

xxiii[23] Concepcion-Rosabal B, Rodriquez-Fuentes G. Simon-Carballo R. (1997) Development and featuring of the zeolitic active principle FZ: a glucose adsorbent. Zeolites 19:47-50

xxiv[24] Rodriquez-Fuentes, (1997) Enterex – anti-diarrheic drug based on purified natural clinoptilolite, Zeolite.

xxv[25] Ueki, A, Yamaguchi M. et. al. (1994) Polyclonal human T-cell activation by silicate in vitro. Immunology 82:332-332






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