I learned about 6 months ago that I had no cartlidge left behind my kneecaps. The pain had become tremendous. I began using Glucosamine & Chondroiton for about 3 months hoping it would help relieve the pain but I didn't really notice any difference. Then a woman told me to add Hyaluronic acid to this each day, that it helps your body absorb the glucosamine better. So I have now been taking this in addition to the Glucosamine & Chondroiton, and have noticed major improvement. Much, much less pain. I noticed improvement in a couple of weeks. It has now been about 2 months and my pain is still very much diminished and I would even describe it as managable. Hope this info helps others.