Wow, that is a lot going on.
DEC is a clue, not a solution.
You stated so much, I feel a short basic parasitology review will help new readers.
This "core" narrative only addresses worms, and not other pathogens, which also can be involved.
There is much to know, so understanding each med, the family of
parasites it addresses, dose, duration, effect, is essential. Threshold, Nominal and Max dosing knowledge is essential. These are all calculated in mg/kg, but a few are calculated in ug/kg.
FLAT Worms:
Yes, Flat worms, Playhelminths, trematodes, (Flukes, Blood Flukes, and Tapeworms) are key to making progress in infections. They are the first layer that must be removed. Like Peeling an onion, the first layer must be removed to treat infections from other families of parasites. Flat worms are the first layer that must be removed. Flat meds are PZQ, TCBZ, ALB, Vitamin D, Calcium, Alinia. Gigantic flukes may require LEV. Prehistoric flats may require Organic oils.
Your first kill. I tried all the meds and could not kill anything. That is when I discovered, all infections must be treated at one time. Holistically. Stasis (some control) of other infections, like White or Red worm infections must be also dosed at the same time to cure flatworm infections. Minerals, Metals must be in balance, etc. it gets complicated, so when I finally crushed my flat worm infection, I documented everything in Document 255. A first step. Then onto the next step.
WHITE Worms: (Ascaris, Ascarids, Hook, some Rope worms)(2 wall worms)
Once clear of flatworms, one moves on to clearing white worms. White worm meds are ALB, DEC, MBZ, OXBen, Tribendimidine, Papain Papaya Latex, Piperazine or Natural Piperazine, Pyrantel, Oregano, etc. The white worm can have up to 7 stages, so white worm formulas seam to be a bit more complex. For My Ascaris, I used Papain for eggs, DEC for filarials, Piperazine for worm pee nitrogen, sulfur for human immune system strength, OXBen for Adults, ALB low dose, MBZ weekly, Doxy and Oregano weekly, etc etc etc. A complex formula for a complex worm.
ToxoCara Canis seams to require Tribendimidine and who knows what else. MBZ. Others are about to crack and cure this infection.
RED Worms: (3 Wall worms)(Strongyles, Strongyloides, Strongyloidea, Strongylida, ...)
Then there are red worms. IVM, FenBen, OXFen, Thyme, Doxy, Flax seed oil, LEV, Pyrantel, and who knows what else. Depending on the species, several approaches are required. Over the years many formulas have been developed, but few work exactly the same. So a person usually needs experimentation to get their exact formula tuned in.
Sequence:
The sequence of removal of parasitic infections is flat worms, white worms, then red worms. I kept on the formula, until cured, and them moved on to the next one.
Golden Rule:
The first lesson of curing parasitic infections is that one needs to suppress or put into stasis, all the infections at the same time.
So to cure flat worms, you also have to suppress white worms and red worms.
To cure white worms, after you cured your flat worm infection, you have to suppress red worms.
To cure red worms you must be free of flat worms and white worms, and need a great deal of luck.
Red worms can be the toughest family to cure.
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So with that said. You indicate DEC is breaking the next bottleneck.
DEC is key, your finding and observation. What does that mean?
So a filarial L2 stage of a white worm is your next keystone moment, towards a cure.
Filarials is both a stage and a worm species term. Filarial term is misused often. It is important to know are you dealing with a hyper filarial stage of Species X, or are you dealing with a Filarial species, where the most populous stage is a filarial stage, and hence why they call it a filarial worm infection.
If you have "filarials", depending on species, the go-to meds are usually IVM, ALB, DEC. I would have to research the species you suspect, but a regular pattern, is usually employed, some filarials are hard to cure, requiring you to dose for up to 7 years. Complicated infections can mask the response to these meds, but if you have a filarial infection, the response to a nominal dose of either of these three meds will be about the same.
Filarial worms, can have a microfilarial stage. The smaller the nematode the more severe the symptoms. Having skin necrosis? This could be from a microfilarial stage of a filarial worm infection. Dark circles under eyes? Changes to pigment in blotches? Having a microfilarial white typically indicates a worm with several stages, normally the stages vary widely in their presentation of symptoms. A more complex species.
WHO may say dose once per year for a filarial worm infection, but in reality if you have other complications, your routine may be daily, weekly, monthly, depending on how many other
parasites complicate your infection.
Say you have a microfilarial stage of a filarial worm, then DEC causes remission, maybe even at a low dose like 100mg, if taken daily. Dirofilarial stage may require a higher dose, maybe 200mg per day.
Ascaris in a hyper state, maybe require 400mg+ per day. So we can gauge the opposition by the dose required for remission. If you have a filarial red worm stage, maybe you need to adjust flax seed oil for red worm filarial stage remission, and balance that against DEC for white worm stage remission. If you find you need both flax seed oil and DEC, but the total required dose is lower, then you can conclude you have infections that have both red worm and white worm filarial or microfilarial stages.
Microfilarial stages can be confused with Trypanosomes, so verify you do not have a trypanosome infection using those natural products like thyme.
The next formula needs a routine of stasis for red worms, periodic red meds to peak your health. So document, I need a IVM dose once a week, or once a month. Use these as guidelines that point to a specific species or infection that is dominant.
Then vary the elements of white worm meds till you focus on and eliminate, maintain (maintenance), then cure your white worm infection.
If you can figure out which adult stage med works, then it helps you figure out the species. OXBen is for Ascaris/Ascarids. Mebendazole is for ToxoCara, Pyrantel is more for a GI worm infection species. Clues help. Your goal is to determine which white worm meds have influence, and how. Pyrantel dose works for 3 weeks? Mebendazole needed for a week strait to budge the infection?
You covered a lot of ground and data, but now is the time to get focused.
You went into several directions quickly, but knowing which stages a med is primarily for, and the worm life cycle duration's of dosing to tamp down a stage, gives clues. Then once you have a species probable list, go into which species provide a match to your symptoms.
Documentation, brainstorming, and having someone else that has been at this stage of the infection, to get ideas is essential.
This is a game of tiddlywinks. One piece of the puzzle at a time.
We know you are likely attacking white worms, hooks or other such worms.
Keep your DEC dose at or below 8mg/kg/D
Keep your ALB dose at or below 4mg/kg/D.
Your Daily MBZ dose is dependent on species, I would look at 100mg per day.
Determine if Papain is required.
Determine if Piperazine is required.
Determine if Pyrantel is required
Determine if OXBen is required
Then map out your species.
I suspect you will find Mebendazole will be more powerful than Oxibendazole.
I suspect several other of the white worm meds will have little or no effect.
If you have ToxoCara, you may want to get into the FaceBook group, to try Tribendimidine. Worms out skin and eyes are typical symptoms.
Focus on clearing white worms now, while taking a weekly dose of IVM, or maintain red worm infections by a maintenance dose of FenBen or OXFen.
Cure your white worm infections first, before trying to address any red worm infections.