I'm in my early 50s, have been having mambo hot flashes and irritability (sometimes outrage RAGE!), can't sleep at night, miserable generally. I took a ZRT morning-only saliva test (estridiol, progest, DHEA, cortisol) that showed my estrogen to progesterone ration was low, and that my cortisol was very low in the morning. I'm also hypothyroid. So, I'm using natural progesterone cream and natural estrogen creme, and thought I felt better, Yesterday, though, I added some ashwaghanda, and felt even angrier, almost crazy! Does anyone have any advice? I'm at the end of my rope! (Not really, but sure feels like I just can't get any relief from these hormone problems!)