I've had worms since I was a child. When I give myself an enema, I see them in my stool, and I can feel them moving frequently. I also found what I think must have been a liver fluke in my stool yesterday.

I've tried the usual treatments -- mebendazole, pyrantel pamoate, and ivermectin. I finally got fed up and took a big dose of ivermectin (120mg). That's the amount in a tube for deworming a horse. And now I have bizarre visual side effects.

According to this study, 120mg should not cause major side effects: http://www.ncbi.nlm.nih.gov/pubmed/12362927
. Poison control said that it shouldn't be toxic until about five times the dose I took. But this morning, I'm having definitely strange visual effects. My peripheral vision is darkened. I can see fine -- I went to the ER, and they gave me visual tests and I'm 20/20 and my eyes respond normally. But things definitely look too dark. I might have very slight ataxia too. I seem a little less graceful when I move, though that could be the visual effects.

I took it at the same time as Ambien 10mg, and it looks like the CNS symptoms ivermectin can cause are by means of GABA, and Ambien is an agonist for a particular GABA receptor. I didn't find any interactions between them on drugs.com, though you're not supposed to take ivermectin with benzodiazapines, and Ambien works similarly to benzos despite not being classified as one.

Does anyone have any ideas? By the way, I haven't felt any worms since I took the dose, but i haven't had to defecate yet, which is unusual. If the ivermectin is causing GABA-related nervous system inhibition, this would make sense, as it'd be inhibiting my enteric nervous system activity which causes gut peristalsis.