When used with corticoid treatment, glycyrrhizin interferes with 5 beta-reductase breakdown of corticosteroids, thus prolonging its biological half-life. When someone discontinues the use of licorice after consuming it over a long period of time, they should withdraw from it slowly, unless they are discontinuing it due to side effects. In the case of dangerous side effects, they should immediately withdraw from its use.
It also worked for me a few weeks ago. My nervous system would not shut down. From 9 Am in the to the next morning at 5:10 when I decided to try a cup of licorice tea.Me too. To this day I use it to "crack the back" of high coritsol days. Especially if it's blood sugar related in the am. As with Sherpa, when things were bad, I used to slip it throughout -- that really seems to balance things the best. I had more around 2pm or so. Cheers! A+