So, a mere 100 mg a day (about 1/18th of the AMA amount) is probably not an issue for most mammals weighing over 100 pounds, would be my expectation.

But, consult with your physician before doing anything. Remember, FDA rules do not permit the statement "prune juice cures constipation" to be put on the label of prune juice until studies are conducted - for a very good reason.

Max would be 600mg x 4, or 2,400mg of SSKI as an expectorant.

There should at least be a detox warning for such a high dose, given that most people never get over 100 mcg daily.