Chelation Lessons Learned

Written by Julia Trudeau   

Monday, 18 December 2006

This is a message Julia sent to Gary Littleton and to Andy Cutler summarizing her very valuable insights into chelation using sulphur chelators like DMSA and ALA that need to be taken on a timed (usually 3-4 hour) basis:

I start all adults on 25mg DMSA. My patients, who all are still able to work, all handle AdvaClear with the DMSA. After the 5th patient said, “I’ll never chelate without the AdvaClear again,” I don’t let anyone chelate without it. Mainly tiredness, yeast or headaches if they don’t use the AdvaClear. I’ve found one AdvaClear pill with each dose of chelator works better than anything less.

There are a few adults who go right up to 50mg DMSA then 100mg DMSA, but just as many who have to move down to taking ½ or 1/3 of a 25mg pill of DMSA.

Almost all side effects of chelation are a result of redistribution, directly or indirectly. Redistribution happens even if timing is right if the person takes more of a chelator than they can handle.

Timing doesn’t matter nearly as much (and might not matter at all) if a person is taking the amount of a chelator that stirs up just the amount of mercury (or less than the amount) their body is capable of eliminating.

The quantity of a specific chelator a person can handle may be very small.

They might be able to handle a very small amount of one chelator, but a rather large dose of another chelator.

Avoid ALL side effects of chelation or it is possible for the person to worsen rather than improve over time.

Yeast flare ups with chelation are often (possibly always) a result of redistribution.

No redistribution = no yeast.

It is better to avoid creating yeast with chelation than try to kill it after its growth has been stimulated. Of course I don’t mean avoiding creating yeast with chelation by avoiding chelation. I mean finding a way to chelate that doesn’t encourage yeast.

Taking AdvaClear during chelation (if tolerated, I haven’t had a patient yet who couldn’t tolerate it, but I’m sure they are out there) is the best way I’ve found to avoid growing yeast.

Increasing Phase II without increasing Phase I liver function is probably the main reason AdvaClear works.

I do not like AdvaClear on non chelation days because of the NAC in it. I think NAC stirs up mercury. I don’t mind stirring up mercury if there is a chelator around.

I have used MCS II by Biotics for balancing phase I and II instead of AdvaClear It has lipoic acid in it, maybe 20mg per pill so this has to be accounted for and dosed at every 3 hours. For those patients who are chelating with lipoic acid and not DMSA this can be easier. It means one less pill every 3 hours.

I’ve tried the individual components of AdvaClear on myself to see which one, if any, seemed to be having the most effect. It appears to be the watercress glucosinolate. I tried Oncoplex, by Xymogen which is 30mg of sulphorophane glucosinolate and that seems to have the most beneficial effect, but I just started this trial this year and I haven’t tried the Oncoplex with chelation, just by itself on non chelation days.

I wanted to know this, one, because there are a lot of ingredients in AdvaClear that a person could potentially be sensitive to. It would be useful to know which ingredient is doing the most good in case someone is sensitive to something in the AdvaClear. Also, I would like AdvaClear to be available without the NAC and then I would be comfortable giving it on non chelation days, but it isn’t available without NAC, so I want something else to use for non-chelation days and one pill would be easier than several.

EVERY patient is in a hurry to get the mercury out and if I had to write anything about chelation for the general public I would probably mention FIRST that EVERYONE, if not strongly warned about it first, will make the same mistake of overdoing it. And this is ALWAYS a mistake.

ZERO symptoms are acceptable during chelation or it will take longer, not less time to detoxify. It is appropriate to get some symptoms in the attempt to find out how much dose of a chelator will cause symptoms and take just the amount less than that.

About three months of chelation without side effects will completely change the way a patient’s musculoskeletal system feels to me during adjustments. I’ve found this to be more consistent than the patient’s subjective reports of improvements with chelation.

Here are some sure signs that a person is mercury toxic that I don’t usually see mentioned. These are all things I’ve noticed on the first meeting of someone that made me wonder if they were mercury toxic and later found out for sure they were. Furrowed brow much of the time, even slightly. Excessively dry skin. Allergic shiners. Could cry at the drop of a hat. Excessively irritable. Just about any odd skin stuff, blotchy, red, patchy, dry.

Hair tests are almost completely useless for lead. If it says there’s lead, there’s lead. If it says there is not, there still could be.

Really only recent exposure to lead shows on the hair test, pretty much like mercury.

The only people I see with mercury itself showing on hair tests are people who have gotten it recently from fish.

If I look back at my various mercury exposures to see what really put me over the edge, it was eating tuna fish. I really only ate it about 1 time per week too. Usually it was tuna steak instead of tuna in the can though, which I know is worse.

Pay attention to the color of stools during chelation. If they start out light colored or lighten during chelation, do something about it. I like Beta Plus by Biotics or AF Betafood (if the person isn’t gluten sensitive, there is gluten in this) and/or P-5-P to increase bile production

Julia 

Tags:  Mercury Balancing Mercury Julia Trudeau Chelation Lessons Learned dmsa phase1 phase2 detox pathways chelation candida yeast advaclear 

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Supplementing B-Vitamins

Written by Julia Trudeau   

Monday, 18 December 2006

This is a message Julia wrote to Gary about B-Vitamins: 

All mercury toxic people are low in B vitamins. Both because of methylation defects (mutations) and because of methylation blocks by mercury, aluminum, and/or lead. I'm sure there are other things that come into play as well. B12 is the one that every toxic person needs. I haven't found an exception to this, but there might be some. It can be taken orally if there is intrinsic factor in the pill. Metagenics has Intrinsi-B12 with folate, and Vessel Care. They both have intrinsic factor in them. I take 1 Vessel Care per day. Vessel Care was the first thing to help me when I was at my worst.

Vessel care did stimulate methylation for me, did give me euphoria and did make my arms a little tingly, not numb though. It didn't seem to effect my bile production though.

By the way Amy Yasko lists many of her protocols for a variety of conditions on one of her sites. Other supplements vary, but every one of them has intrinsi-B12 with folate included. She only has people take 1/4 of one pill per day though. If you dowse for this or vessel care I think you should try just 1/4 of a pill at a time.

The difference between Intrinsi B12 and Vessel Care is that Vessel Care has trimethylglycine (betaine) in it. Some people don't do so well with the betaine. I have an autistic boy patient who improves on dimethylglycine, but worsens witih trimethylglycine. This is one example of how I said it can get hard to treat people when there are so many individual variations on things. In actual clinical settings, this becomes very readily apparent, and quite a problem. I do better with the trimethylglycine added, that's why I take vessel care.

If there is no intrinsic factor with the B12, don't bother swallowing B12.

Take it in a sublingual form, or a shot. I don't see any reason to take the shot though since the sublingual forms work fine if you just take enough of it. Most of the injectible B12 that pharmacies carry have aluminum in them as a preservative also, except for Tahoma clinic dispensary in Seattle. 1mg sublingual doesn't usually do much, it usually takes more like 5mg. Some people do better with methylcobalamin, some better with cyanocobalamin, some hydroxycobalamin. It has been suggested by Yasko that having a little of each is best. In that case, the 1mg sublingual pills might be helpful so you could mix them. I haven't tried that myself. 1mg pills might be better to start you out with also so we don't go stimulating so much methylation in you that other things get out of balance.

Between using sublingual b12 and a preparation with other methlating things (the Metagenics products), use whichever you dowse for, but don't go by dowsing for dose. Just start really low.

2nd big supplement that toxic people are low in is thiamine. I like Bio-3-BG by Biotics Research. If a person is thiamine deficient they will usually get up in the middle of the night to pee more than once and they will have some muscle soreness problems. Maybe only when they use their muscles a little more than usual, not necessarily always, like with fibromyalgia.

The reason I like Bio-3-BG is because it has all of the b vitamins in it, just extra thiamine. They are mostly in their phosphorylated forms also.

Toxic people will need to supplement with B12 always and extra thiamine sometimes, but it is always best to have a base of all the b vitamins with them. Not just B12 alone or thiamine alone.

I use the Bio-3-BG for my base of other b-vitamins, but if a person didn't need the extra thiamine use Bio-B100 by Biotics Research or Max stress B by Premiere (Dr. Bob Marshall's company). Max stress B is just brewers yeast that has been predigested by probiotics. It is liquid.

I actually also take extra trimethylglycine in the form of Beta Plus by Biotics, but AF Beta Food by Standard Process worked even better for me, but has some wheat product in it and I couldn't take it for long without bad headaches.

I personally am quite low in both B6 and thiamine as evidenced by my tendency to have numb arms (B6 deficiency) and delayed onset muscle soreness without much extra activity at all (thiamine deficiency) so my daily B-vitamins look like this:

• 1 Vessel Care by Metagenics per day
• 3 B6 phosphate by Biotics Research per day
• 3 Bio-3-BG by Biotics Research per day
• 3 Beta plus by Biotics Research per day

It took me a long time to figure this out for myself. Please note that this amount of methylating things will stimulate a fair amount of detoxification without any added chelators. I really doubt that you could handle this quantity of things. Much better to start out slow. The only exception to that is just straight B12. I've heard that you almost can't give too much of it to a toxic person. I don't know if that is true though. It still wouldn't hurt and will only help to start out slowly with everything after dowsing.

I will reitereate that I think that getting B vitamins straight, minerals, essential fatty acids and amino acids seem to be the most helpful.

I have only recently been supplementing with amino acids. I've been doing the other three even long before I started chelating. I got the most noticeable symptomatic improvements from taking the b-vitamins and minerals.

I like Multi-Min Chelate from Metagenics the best for minerals. I take 3 per day. That and Vessel Care were the two things that helped me the most.

AMNI has a multi-mineral without iron that is something like Multi-Min Chelate, but you take 6 per day. Some people do better on it than the Metagenics product.

I have been experimenting with a general free form amino acid preparation and that has been helpful for me, but when you get into sulfur sensitivities you will have a much harder time getting this straightened out.

Start by dowsing which would be the best of the 4 to start with. I'm sure it won't be amino acids. Then only work on one of them at a time.

Julia 

Tags:  Mercury Balancing Mercury Supplementing B-Vitamins dmsa chelation 

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No Mercury Detox Protocol Is Safe

Written by Gary Littleton   

Tuesday, 19 December 2006

When you research across specialized boundaries, sometimes it is easy to see patterns that you never see when sticking in one area of science.

Back when I decided to research what was causing my ADD/ADHD symptoms and other health problems, it didn't take me long to determine the problem. In fact, I'd say it was one of the most obvious (and depressing) conclusions from a research project I ever had. I determined quickly that most of the health issues being experienced today where the methods of treatment are largely ineffective, such as Autism, Cancer, ADHD, AIDS, EMF Sensitivity, Multiple Chemical Sensitivity, Wilson's syndrome, hypo and hyperthyroid and other emerging Indigo Child issues are primarily due to mercury disrupting the body and the highly misunderstood and critical ways that iodine is used.

When I tried to communicate that Autism, AIDS and other problems were mercury related 12 years ago I also got to understand the politics of medicine better and it is not pretty scenario. Now at least others are making the connections and the problem is becoming known. The bad news is that figuring out the problem was easy, but figuring out the solution, which is detoxing mercury and restoring the correct iodine function of the body is not so easy.

Unfortunately, all methods of mercury detox are dangerous and risky. Doctors and companies that sell products will tell you otherwise, and that it is safe to do DMPS, DMSA, EDTA, NDF, NDF+, BTM, etc but it isn't true. They all can have very serious side effects.

The two best protocols I have researched are Biorays BTM (http://www.healthydetox.org), which uses NDF, NDF+ and liverlife as it's primary metal drainage strategy, and the Andy Cutler protocol (http://www.noamalgam.com), which uses sulphur chelators like DMPS, DMSA and ALA on a strict timed dosage schedule in an attempt to minimize redistribution of metals.

Both Bioray and Andy Cutler imply it is easy to detox mercury, or that there are no side effects, which simply isn't the case. You can and probably will have severe reactions to either protocol, and both can have life threatening results. Really.

For example, you can't use a sulphur based chelator without recirculating mercury. It is not possible because of the way iodine works in the body. When the body iodates cells any mercury bound between cysteine di-sulfide bonds will be broken, released, and then reused.

Most doctor protocols that use sulphur chelators (DMSA and DMPS) are to be avoided at all costs. Without consistent timing or determining if phase1 and 2 detox pathways are open these can cause severe damage due to recirculation.

Better sulphur chelator protocols like the Andy Cutler protocol that time dosages do a fair job of minimizing recirculation and can be beneficial, but they can't stop recirculation. That is why mothers of autistic children using his protocol go through round after round of alternating between pulling mercury, and then fighting yeast as the mercury is unbound in a more inorganic form in the body where candida can form on it. Read the mercury-autism group on Yahoo to see what these poor parents go through.

In either the BTM or Andy Cutler protocols, I have found it is critical to add zeolites and iodine supplementation to the protocol. Zeolites can keep the mercury from being recycled and reused via the small intestines. I have seen good results using the zeolite called Natural Cellular Defense (NCD) from Waiora, but there is little useful data on this supplement, and it is one of those distributed marketed items, which means it comes with a barrage of BS marketing and is also greatly overpriced, as are most products from these companies.

Even if the products are good, they require huge profit margins to support these pyramid marketing models. Also distributors of NCD quote a patent quite often, but the patent I have seen does not cover taking NCD orally, so once again it is just more BS.

What it boils down to is we still need to a lot of research and work to figure out how to detox mercury effectively and restore the iodine function of the body. We need to find a zeolite that has a very high or specific affinity for mercury when taken orally that doesn't distrupt the uptake of other essential nutrients in the intestines.

Supplements like NDF and NDF+ also unbind and chelate iodine and disrupt how it is used in the brain, which can cause seizures and other VERY serious problems. NDF+ can also methylate mercury when the body burden is high with deadly results.

In many cases a person might decide the risks of trying to detox mercury outweigh the alternatives. I have been forced to do it personally and I certainly would if a loved one had a serious health problem or I had autistic or highly ADD/ADHD children or ones with some other mercury related problem. But just remember there are a lot of risks.

Sometimes I wonder if anyone besides me are getting tired of all these "experts" telling you they have all the answers when they don't. The health stores are full of pathetically researched books and supplemenets by people that "have all the answers". I figure its about time to honestly look at what we do and don't know. Stay tuned. Gary

Tags:  Mercury Mercury Background No Mercury Detox Protocol Is Safe DMSA Andy Cutler NDF NDF+ Bioray Iodine Lugols 

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ADHD/ADD NDF Protocol

Written by Gary Littleton   

Thursday, 11 January 2007

Dorothy who teaches QXCI training asked about the ADD/ADHD protocol for kids that we've seen good results with. This is the message I sent her today.

Here is the simplest ADHD protocol we've seen consistent results with (and what Addison's nephew is doing). He is happier and his grades have improved from Ds and F's to C and B's in a month. He looks people in the eye now and his lying has stopped along with many attitude problems. There are other things you can do to monitor where the body is at and adjust the terrain, but this one seems to have universally good effect, especially with kids. Probably because it is low enough dose not to cause recirculation of metals. If I've reached any conclusions regarding mercury detox, it is that you have to go slow enough to not have recirculation. Dr. Julia Trudeau who has quite a bit of experience with mercury, wrote an excellent summary called Chelation Lessons Learned which I put on my personal website. Even though she talks about sulphur mercury chelations like DMSA, and this protocol uses NDF, a different type of binder, all of her conclusions are excellent and very valid. I suggest you read it when you get a chance.

Only do this protocol if you do NOT have mercury amalgams (silver fillings). It is dangerous if you have fillings because it will pull mercury off the fillings and you will swallow it.

First thing in the morning, before doing anything else.

1 drop NDF (Bioray Nano Colloidal Detox Factors, we get it from http://healingedge.net ) They also have a supplement called NDF Plus, but DO NOT USE IT as it contains probiotics and can cause serious side effects). 

1 drop Liverlife (Bioray, same source).

Put both in a little distilled (homemade, like with a waterwise 9000, don't use store bought distilled in soft plastic bottles, as the polyvinylchloride leeches into the water, use RO instead) or Reverse Osmosis (Dasani, Aquafina) water, and drink. 

If you can get the kid to drink water, have them drink distilled or RO water until they have had the 2nd urination. If not we haven't seen any negative effects not doing it, but metals usually come out on the first or second urination after taking NDF, so water during this period is useful. Repeat daily. You will usually see slight benefical changes within a few days, and very noticable over a period of two weeks. Keep doing it for at least a month.

Monitor bowel movements. Any out of the ordinary side effects or signs of constipation stop the protocol until normal bowel movements are back. Some don't measure ph but it is a very beneficial addional parameter. If the urine ph goes up during the day and is above 6.4, or above the saliva pH at night. (we use a meter, but the ph strips from http://www.ph-ion.com are pretty good). Then you can ramp up the amount of liverlife from 1 drop to 5 drops and this should lower it slightly. The urine lowers because the body is eliminating more acids as a result of liverlife helping the phase1&2 detox pathways.

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Are we the Mad Hatters of this Century?

Written by Patricia Braun   

Tuesday, 19 December 2006

This is an Outline of a Lecture given in 1997 by Patricia Ann Braun, M.D

I. Chemical and physical Properties of Mercury 

A. Symbol Hg, for Hydraargyrum -- liquid silver, or watery silver (silver symbol is Ag) 

B. Liquid ( changes from solid state) at -38.9 0 C., -38.020 F. 

i.e. mercury is a liquid at the temperature of iced tea 

C. 13.5 x heavier than water 

II. Ancient history 

A. Known to Ancient Chinese, Hindus, Egyptians, and Greeks: 

1. Pliny described the diseases of Hg miners 

2. Well recognized as a toxin throughout history 

B. Source: Mineral Cinnabar (HgS, sulfite of mercury), recovered from land mines. 

1. Worlds oldest mine in Almaden Spain, still providing 15% of annual world production 

2. Spanish miners ills have been well documented 

3. Victorian tall hat makers were well known to be toxic 

II. Uses of the various forms of Mercury 

A. Elemental Form Hg and Salts HgCl, etc. 

1. Dental Amalgams "silver fillings" 

a. 70 % of the adults in the western world have amalgams 

b. 100 tons of Hg a year, are used by U.S. dentists 

c. several formulae: 50-52% Hg, 22% Ag, 12% Cu, and Zn and Sn 

(mercury, silver, copper, zinc, and tin). 

d. ADA, (American Dental Association) until a few months ago (as of date 7/97), 

held two patents on the formulae. Sold them. * 

2. Liquid in thermometers, barometers, b.p. meters, silent switches,

kids light up sport shoe, lab. equipment, batteries, electrodes, etc.

3. Fulminates of Hg : detonators of explosives (Hg(ONC)) 

4. Sublimates : antibacterial salts 

a. Cleansers 

(1) for walls and floors of hospitals, laboratories, nursing homes, 

(2) and for instruments. 

b. Calomel (mercurous chloride salt): used internally as purgative 

(for parasites and fungicide.)

5. Preservatives in vaccines (Thimersan): Flu vaccine, D.P.T. on up to newest ones,

Hepatitis B and Hemophilus 

6. Fungicide and pesticides, and mildewcides (Hg2Cl2, ) and other salts 

a. a violent poison : two recent laboratory sudden deaths (hours) 

b. Uses: 

(1) Outdoor textiles and fabrics 

(2) Control of Dutch Elm disease 

(3) Turf fungal-disease control 

(4) In-can additives to Latex Paint 

(5) Disinfectant of commercial farm seeds: 

(problems since 1952 have finally changed this)* 

7. Vermilion pigment (no longer allowed in U.S.) 

8. Manufacture of paints and plastics, in dye industry, etc. 

9. Burning fossil fuel (entire petroleum, and solvent industry) 

B. Organic forms : Alkyl mercurials --- methyl, ethyl and aryl 

1. Uses 

a. Cosmetics 

(1) In Mexico (very heavy levels: do not use them) 

(2) In hair coloring : major brand in the U.S. (C.) 

b. Cultural use as aphrodisiac, sprinkled on floor in Folk rituals 

c. Medical use: 

(1) Ointments and creams: yellow and gray ointments for eyes and skin 

(2) Lotions and tinctures: 

(a) Calomel (oral purgative and fungicide) Caladryl 

(b) Mercurochrome, (painted umbilical stump), 

(c) Merthiolate (painted on raw wounds and hot tonsils) 

(3) Treatment for syphilis from 1500's 

(a) Arsenicals replaced it in 1900 

(b) Penicillin replaced arsenic in 1940 

(4) Diuretic in 1900's (mercurial salicylate) 

(5) Homeopathic use: try to avoid any molecules at all 

(6) In injectables 

(a) ACE - adrenocortical extract , injectible from Switzerland 

(still used in Mexico: recently stopped here) * 

(b) Vaccines: flu, et. al. 

(c) Rhogam (antigen given to Rh negative mother after a Rh + baby, 

2. Conversion to Methylmercury 

a. Air borne mercury 

(1) Industrial use puts 55 tons of Methyl mercury into the air each year: 

(a) Chicago is the worst 

(b) No place is safe. 

(2) Volcanoes and forest fires are major mercurial loading events to the air 

(3) The industrial uses and rain after natural events discharge 

mercurial forms into the waterways, creeks, streams, and lakes; 

eventually the ocean. 

b. Water borne: methylmercury is the common poison 

(1) Created when the inorganic forms enter fresh water and saturate ocean sediment. 

(2) Studied : 

(a) first in fish and predatory birds, in Sweden in 1950's: due to effects of wildlife 

(b) later in epidemics of illness in Swedish men 

(3) Sources to humans: until 1996, thought to store chiefly in 

(a) bottom feeders (scavengers and shell fish) 

(b) largest ocean fish: tuna, blue fin marlin, shark and swordfish * 

IV. Physiology of methylmercury in the human 

A. Entrance into our body 

1. Elemental Hg goes through alveolar bone and through mucous membranes of oral cavity : 

a. soluble in saliva 

b. galvanization by dissimilar metals in bridges, crowns, gold 

c. Streptococcus mutans in mouth converts Hg0 to methylmercury 

2. Elemental mercury vaporizes from the dental amalgams during drinking and chewing:* 

a. electron micrographs show droplets on the surface of the filling 

b. breath analyzer tests 

3. Swallowed with the saliva, laden with soluble ions 

4. Enters through skin 

5. Inhaled, going directly into blood stream, during dental polishing and repair 

6. Through GI (gastrointestinal) mucosa, bypassing most bowel detoxication 

a. Bacteria in bowel make methyl-Hg from the inorganic forms and salts of mercury, which: 

(1) Alters bowel flora: reduces numbers of beneficial bacteria 

(a) decreases SCFA that feed our lining cells 

(b) fosters the growth of yeasts * 

(c) allows colonization by amoebas and parasites 

(2) Creates bacterial antibiotic resistance (fosters bad bacteria) 

(3) Damages enzymes systems of the GI mucosa : 

(a) decreases the 25 % of detoxication done there 

(b) decreases sIgA (secretory immune globulin A) so we do not resist the bad bacteria: they infect us 

(c) adds to the effect of leaky bowel syndrome, creating food allergies 

b. eating fish gives methyl-Hg directly 

eating 2 cans of tuna per day will give acute toxicity 

7. Crosses all lipid membranes 

a. Cell walls (70 % lipid and 30% protein) are penetrated 

b. Myelin sheath, the insulation of nerves is eroded 

(associated with MS, and other de-myelinating degeneration) * 

c. Blood brain barrier (BBB) is traversed 

(1) 800 % increase in the incidence of brain cancer 

( ? Nutrasweet) 

(2) Produces massive brain effects : 

(a) encephalitis effects of sudden heavy exposures (acute) as in Minimata Disease 

(b) encephalitis long term slow effects similar to vaccine effects (chronic) 

B. Biochemical effects: 

1. Depresses MAO (monoamine oxidase, an enzyme of brain function) causing the 

characteristic depressions of Hg toxicity. 

2. Combines with SAM (s-adenysylmethionine) in the enzyme systems of all biologic life 

3. Binds to the heme ring (porphyrin) ring of hemoglobin and myoglobin (part of the muscle protein) 

a. Anemia 

b. Fibromyalgia 

4. Decreases mitochondial production of energy: CFIDS 

a. Immune system has to operate on energy 

b. CFIDS is: chronic fatigue and immune deficiency syndrome 

5. Hg attaches to the SH (sulfhydryl group ) 

a. in enzymes and deactivates or reduces the rate of reaction of the enzymes 

b. in the proteins in blood, which account for 10-50 % of antioxidative capacity of the blood 

c. reduces the antioxidant functions both in the blood and inside cells. 

6. Hg inactivates thiolic antioxidative compound: glutathione, which has the principle role

in rejuvenating Vit E for cyclic reuse. 

7. Hg effects oxygen transfers (intracellular peroxide functions) 

a. Hg inactivates SOD : interferes with oxygen transfer 

b. Hg inactivates catalase: 

(1) slows oxygen transfer 

(2) inhibits kill effect on "resistant staph" related to skin infections in nurses, hospitals 

8. Hg forms insoluble complex with selenium (Se): 

a. Se is a cofactor for glutathione peroxidase 

b. Se is a cofactor in tetra-iodothyroidine deiodinase: leading to Reverse T3 syndrome 

c. Se prevents fibrocystic breast disease, other cysts 

9. Hg causes decreased liver transformation of ATPase :mitrochondrial enzyme that produces our energy 

a. Heart failure is now defined as energy failure so fibers can't contract. 

b. Chronic fatigue : mitochondrial energy failure 

10. Hg interferes with DNA synthesis ( i.e. messes up our genes): 

a. mutations, birth defects: California Law 

b. cancer 

11. Hg blocks receptor sites for progesterone & interferes with estrogen 

a. interferes with reproductive functions 

b. bone metabolism 

c. heart function 

12. Causes thyroid malfunction (Se enz. for Reverse & T3 and other modes) 

13. Causes adrenal malfunction 

14. Hg found to be neurotoxic: inhibiting polymerization of brain tubulin : 

a. Alzheimer's 

b. MS etc. 

c. Peripheral neuropathy 

15. Sets stage for, or causes, "autoimmune disease" 

16. Hg blocks ATPase (stalls energy cycles) 

17. Hg blocks P450 enzymes (vast family of detox enzymes in the liver) 

18. Hg blocks glutathione peroxidase and glutathione reductase 

19. Mercury load both causes and is worsened by deficiency of minerals 

20. Elemental Hg, when detoxified by the thiols (glutathione) is converted to 

methyl mercury which is just as toxic as elemental. 

if redundant...... blame it on the mercury 

C. Significance: 

1. The human body was not designed to handle mercury 

2. We have no mechanism to rid our bodies of it naturally 

a. damages the kidney in effort to clear after heavy exposure: 

accounts for significance decrease of renal function as we age 

b. interferes with liver detoxication of other toxins, 

as we attempt detox in Phase I , 

leading to the spreading phenomenon of MCS 

multiple chemical sensitivity) 

c. excreted through the hair, nails, and skin --- if we are able to, 

requires 

(1) active sulfhydryl pump to excrete, 

(2) adequate mineral stores 

example 

D. History of Mercury Poisoning: 

1. Chronic poisoning was 

a. recognized by Pliny, and in the Spanish miners in 1700, 

b. not a wide spread problem until Hg became widely used in the industrial revolution (1830) 

c. was not recognized in a medical sense until 150 years ago (1850): 

Mad Hatters disease of "Alice in Wonderland" (1889) Lewis Carroll 

2. 20th century recognition of acute disease 

a. Minimata Disease 1956: The classic disease of massive contaminated water from industrial pollution 

(1) blood cell binding: total anoxia (lack of oxygen) 

(2) encephalitis with massive neurological damage 

b. Grain fungicide exposures in Iraq (1956-72), and elsewhere including the U.S. 

3. Current recognition of chronic disease 

a. preponderance of exposures was overwhelmingly dental until 1996 

b. EPA study revealed toxicity of all fish: fresh and ocean 

V. Dental use of Mercury 

A. American experience: 

1. Elemental and methylmercury was widely recognized as toxic 

2. Amalgam, i.e. a mixture of metals 

a. started in Paris in 1820: 

b. Hg barred from dental use 

(1) rejected as it expanded and fractured the teeth. 

(2) widely appreciated to be toxic: from 1848 -1900. 

(3) ADA was formed to censure the use of mercury in dentistry 

(4) Original word "quack" came from "a user of quicksilver " 

3. Brothers Crawcour 

a. came to New York in 1833 with a "cheap filling" 

b. chased out: because dentist knew Hg was toxic (competition?) 

4. 1848, 11 dentists in N.Y. suspended from their society for using amalgam: 

reflected the common attitude 

5. Began to bill amalgams as "silver fillings" (cheap for common man) 

6. In 1910's said it was no longer toxic as it was "stabilized" 

meaning it wouldn't expand and crack teeth 

7. Toxicity was lost in the controversy during stress of WW I and WW II 

B. European experience: 

1. Current speculation: might not have had WW I WW II if not for mercury toxicity in the leaders and people 

2. Scientist studied themselves: German Alfred Stock recorded his own illness: 

Stage i. Fatigue. 

Diminished working capacity. 

Irritability. 

Slight swelling of nasal mucous membranes. 

Stage ii. Extreme fatigue. 

Lack of concentration. 

Impaired memory for names, numbers, etc. 

Irritability and moodiness. 

Sensation of a sheer stupidity.. 

Nasal obstruction with dryness (stuffy nose). 

Nasal discharge, viscous, sticky sometimes bloody. 

Tinnitis. Hearing impairment. 

Headache, often frontal. 

Stomatitis, bleeding gums on brushing 

Irregular heart activity 

Sometimes diarrhea 

Frequent urination 

Slight tremor 

State iii. Headache 

Dizziness & vertigo 

Tremor 

Mental incapacity 

Despondency and depression 

Back pain 

Dysiuria 

Colitis and diarrhea 

Nasal catarrh with bloody crusts 

Loss of smell 

Stomatitis 

Bleeding gums 

Paradentosis and loose teeth 

Increased salivation 

Pharynigitis and laryngitis 

3. Swedes, the most instrumental in showing accumulative effects 

a. in 1950 recorded association with wildlife decline: 

not much concern for those matters then 

b. in 1981 (30 years later) started it over again 

c. reviewed all the old literature and history 

d. showed liquid mercury droplets on the amalgam surface after chewing 

g. corrosion chemist studied his own interaction with Hg and gold crowns 

h. oral galvanism of dissimilar metals: the electrical charge causes neurological problems 

i. correlated amount of Hg in the brain with amount of amalgams in mouth 

C. Comparisons : 

1. American have short memories for historical lessons 

2. Americans are more gullible: 

3. Americans have perhaps more neural storage of mercury 

VI. History in the Scientific Literature 

A. 1970 : Immune dysregulation (see Dysregulation Chart figure) 

B. 1981: Lauren: "the most Important depressive elements on the immune cells" 

in this order Hg++, CU++, Mn++, Co++. 

decreases lymphocyte transformation (part of function) 

while Ni and Pb, increase proliferation of the WBC 

C. 1985: HgCl2 and CH3HgCl decrease thymidine incorporation into DNA of lymph 

D. 1986: T cells autoreactor causes autoimmune disease 

E. 1988: Increases T cells and causes deficit in T suppresser levels: 

combining depressed immune system with increased freq. of infection and increase 

attack on self causing allergy and the spreading phenomenon of MCS 

F. 1991 Glomerulonephritis in rats: antibody to kidney produced in this disease 

remember acute hepatic necrosis 

G. 1991 WHO reported the acute toxic effects due to the Iraq grain events 

Most USA. data came from these studies: 

and at first they only looked at acute (sudden, overwhelming) 

H. Follow-up of the acute Murimata and Iraq cases taught that: 

1. If one survives the acute exposure, illness will ensue and become chronic 

2. and since it does not clear after time ACCUMULATION causes Chronic disease 

H. 1980 + Finns, Sweden banned use 

VI . BOMBSHELLS 

A. 1996 EPA of U.S.A. published Mercury Study Report to Congress VOL. I-8 stating: 

1. There is no safe level of mercury 

2. The fetus is the toxic dump for 

a. heavy metals 

b. excess in general, including "recreational drugs" 

2. No fish / seafood is safe. 

3. Hg is the second most toxic element on earth 

follows Plutonium (radioactive Bomb of WW II) 

4. Hg is worse than Lead: 

a. but mercury and lead are additive 

b. Lethal dose concept : LD50 , LD1 LD100 

LD50 dose to kill 50% of the study group 

LD1 dose to kill 1% of the study group 

LD1 Hg + LD 1 Pb = 100%. Highly synergistic 

B. EPA was asked about legislation to stop Hg use in the USA 

"Litigation, not legislation" was the answer: reading from Queen 

VII . How to determine your mercury load 

A. Hair: 

1. Depends on detoxication ability: sicker patients can not push it into the hair 

2. Is accurate, if one is able to excrete it (except for C. hair products) 

B. RBC: useful only for acute and recent exposures 

C. Whole blood : 

1. for acute exposure only 

2. cleared from the blood as fast and possible, in anyway possible 

D. Chelation challenge with DMPS 

1. Terms: 

a. 2.3-Dimercapto-1-Propane Sulfonic Acid, Na salt 

b. Dimival® from German Company -- Hyel : standard for 40 years 

c. Russian DMPS: 75 % pure 

2. Procedure: after history and physical exam (with notes to neuro findings) 

a. Obtain base-line minerals in urine and hair 

b. Get basic lab :SMAC with ferritin, Mg, lipids, CBC, T7 with TSH, UA 

c. Compute renal ability to excrete creatinine (% function of kidney) 

d. Give serial dilution dose of DMPS under the tongue to assay allergy 

e. Give supplements for two weeks 

f. Obtain UCG (pregnancy test) when appropriate 

g. Give 20 min DMPS IV: dose based on weight and kidney function 

h. Collect 24 hour urine for minerals excretion 

(1) Assess output of Hg 

(a) if over .5 ppb proceed with Hg removal treatment 

(b) If less than .5 ppb, and very sick 

(i) give amino acid + mineral IVs and oral supplements 

(ii) Detox liver, bowel, treat for yeast, etc. 

(iii) repeat the DMPS challenge in 2-3 weeks 

(c) Repeat the DMPS challenge and collect urine and measure 

VII. How to remove the mercury burden : treatment 

A. Repeat DMPS IV each 2-6 weeks, depending on fragility of person 

expected actual 

Cumulative Hg Urinary output curve with DMPS treatment 

B. Required supplementation: 

1. Se 200 micrograms/day (no Kelp unless analyzed for Hg first) 

Chlorella: southern algae (pond scum) with cracked shell 

(a). found to move Hg from cells into fluids 

(b). dose 3-4 x daily, to tolerance 

(c). double usual dose on day of Hg removal & DMPS IV 

2. Vit E , mixed tocophorals, 400-800/day 

3. Vit C 1000-5000mg.day 

4. Cystine 

Cysteine (as in n-acetylcysteine) may move it around, but not out 

5. Glutathione : 300-600 mg/day div. dose 

a. binds with methylmercury 

b. excreted as Hg mercapturic acid in the urine 

c. not to be used in diabetics who are insulin dependent 

6. Garlic: ratio of 1:1 with Chlorella 

7. These minerals if low on any analysis 

a. Zn, Cu, Mn, Cr, Mg, Na, Fe, etc. 

b. Note: there is a constant Mg deficit when Hg is present. 

c. No amount of oral and IV will make up for the drain. 

d. One can not detox with a low sodium (na) 

e. Hg displaces Zn, Cu, 

f. inhibits Fe absorption 

g. no colloidal minerals (Pchem size to great for absorption) 

8. Herbals: Liver detox: Silymarin and immune support, ecchinacea 

9. Vitamins, especially Bs 

10. EFA, Omega 3 & 6 (essential for membrane maintenance, cell walls) 

If fish oil is used, it needs a negative assay for Hg 

11. Eat only organic foods : see attachment: 

12. Use Cilantro in abundance 

13. High protein diet (Atkins, Sears) 

14. Hypericum, as needed 

15. Repeat the lab evaluations at least each 3 months of treatment 

16. Treat until urine recovery is below .5 ppb 

a. average need for DMPS is 17-30 + injections 

b. incomplete treatment is as bad as no treatment 

VIII. Possible ill effects: 

A. Rash: denotes mercury in the skin, binding with the DMPS 

Treatment: B12 IM , 1-2 cc q 2-3 hours through 24 hours, or until it stops. 

B. Wipe out : headaches, fatigue: denotes mercury moving and causing symptoms 

Treatment: GSH (reduced glutathiones) 25/mg/kg, one dose 

C. Rebound reaction: feels good for several days, then feels bad again: 

1. Due to recompartmentalization. 

2. Will stop after enough is removed. 

D. If one has allergies and neurologic symptoms as detox proceeds, 

it could flare and then improve (i.e. the reverse of the above # C) 

E. The T-cell count will improve as one goes through treatment: esp. noted in CFIDS 

IX. The FDA protocol is different in that it : 

A. Involves much more extensive use of the lab: see the attachment 

B. Requires proof that mercury 

1. is not being excreted before the DMPS is given 

2. is excreted after the DMPS is given 

3. that DMPS provides improved objective parameters of improvement 

X. Summary 

A. Mercury is not meant to be in the human body: causes gross malfunctions 

B. Mercury may be one of the primal root causes of 

1. many of our classical old diseases 

heart disease, neuroses, psychoses, cancer, gum disease with tooth loss, 

thyroid and adrenal dysfunction, etc. 

2. most of out "new" 20th Century Diseases: 

Allergies, Chronic fatigue and CFIDS, Chronic Candidiasis, Leaky bowel syndrome, 

Fibromyalgia, food allergies, MCS, anxiety and panic attacks, etc. 

C. Mercury must be removed before the above diseases can be successfully approached or resolved 

D. DMPS has a 40 year record of safety and efficacy in removal of mercury 

E. It should be available to any competent doctor to use for those who need it 

F. The FDA protocol is expensive, as it needs to be, in order to prove efficacy and safety 

G. If one can not afford the FDA protocol 

1. he/she may seek safe treatment without the extensive lab 

2. he/she understands that the risk is future non-availability of the product 

H. If one seeks treatment, they should be willing to sign a release stating that: 

1. they judge themselves to have symptoms compatible with mercury toxicity 

2. they have been informed of the need for mercury removal and 

3. they understand the differences in the FDA protocol and the abbreviated protocol 

4. they are willing to undertake the abbreviated protocol 

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