Treatment Discovered for Pancreatic Cancer - EDIT Treatment Discovered for Pancreatic Cancer - EDIT
Treatment Discovered for Pancreatic ... 
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Treatment Discovered for Pancreatic Cancer
By Barbara Minton
Substances found in green tea and high fiber foods have been found effective in the treatment and prevention of pancreatic cancer, an extremely virulent form of disease with few effective treatments. Pancreatic cancer is the fourth leading cause of cancer death in the U.S., so any indication of an effective preventive and treatment is very good news.
A diagnosis of pancreatic cancer generally comes only in its late stages since there are few noticeable symptoms during the early stages. Patients diagnosed with pancreatic cancer survive an average of only 10 months. 1 of every 36 men will contract the disease in their lifetimes. For women, the incidence is 1 of every 195.
Recent studies and results
Catechin, a phenol occurring in green tea, and inositol hexaphosphate (IP6), a compound found in high-fiber foods have been shown to prevent the growth of cancer cells when administered as single therapeutic agents against a number of cancers. In research done at West Virginia University in 2007, researchers hypothesized that alone and in combination, catechin and IP6 would be effective against pancreatic cancer. (1)
After studying pancreatic cancer cell lines treated with catechin, IP6, and a combination of the two, the programmed death of cells, known as apoptosis, was evaluated Findings indicated that the combination of catehin and IP6 significantly inhibited the proliferation of cell growth compared to each administered separately. In another cell line, growth was inhibited by each agent alone compared to controls. An increase in early apoptosis was attributed to catechin therapy in both cell lines, while the combination of these agents also increased early apoptotic activity. Vascular endothelial growth was reduced by IP6 in both cell lines compared to controls.
The researchers concluded the results, combined with the prevalence of these compounds in safe, naturally occurring foods, make catechin and IP6 attractive therapies and preventatives for pancreatic cancer.
In 2008, researchers at the University of Texas Science Center studied the effects of the catechin epigallocatechin-3-gallate (EGCG) from green tea in a mouse model to examine the molecular mechanisms by which EGCG inhibites growth, invasion, metastasis and angiogenesis (creation of blood supply) in grafted human pancreatic cancer cells. (2) They concluded that EGCG significantly reduced volume, proliferation, angiogenesis and metastasis, and induced apoptosis and growth arrest.
In early 2009, scientists from Metro Health Medical Center in Ohio identified the mechanisms by which EGCG induces growth arrest of pancreatic cancer cells at an early phase of the cell cycle. (3)
Later in 2009, researchers at Ohio State University studied the ability of EGCG to down regulate oncogenic proteins in pancreatic cancer cells. (4) They found that EGCG does indeed induce degradation of cancer promoting proteins, resulting in anti-proliferation.
Most recently, scientists from several institutions in Europe identified two other catechins from green tea, epicatechin gallate (ECG) and catechin gallate (CG) that exhibit potent and much stronger anti-proliferative and anti-inflammatory activities on pancreatic cancer cells than that seen with EGCG. (5)
The catechins found in green tea are polyphenols belonging to the flavonoid family. They have also been shown to significantly reduce the risk of ovarian and colorectal cancer. Along with their cancer fighting abilities, catechins are highly antioxidant and have antibacterial, antiviral, and other health enhancing properties. Epigalloacatechin gallate (EGCG) is the most abundant and most studied catechin in green tea. It has been shown in tests to be able to penetrate the body’s cells and shield DNA. Significant amounts of catechins are also found in chocolate.
IP6 is a naturally occurring carbohydrate found in substantial amounts in whole grains, dried beans, nuts, seeds, rice, wheat germ and corn. It has been shown effective against a variety of cancers. In addition to the arresting of cell proliferation noted in the pancreatic cancer study, IP6 induces the differentiation of malignant cells. The more differentiated the malignant cells, the less aggressive and dangerous is the cancer. IP6 displays antioxidant and immunity enhancing properties which also contribute to tumor cell destruction.
Drinking two or three cups of green tea a day is the best way to provide the full range of its catechins. Supplements of whole leaf green tea are also available, as are extracts of ECGC. Supplemental IP6 is also available from health stores and online.
(1) Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate. McMillan B, Riggs DR, Jackson BJ, Cunningham C, McFadden DW. J Surg Res. 2007 Jul;141 91):115-9.
(2) EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Shanker S, Ganapathy S, Hingorani SR, Srivastava RK. Front Biosci. 2008 Jan 2;13:440-52.
(3) Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death. Basu A, Haldar S. Int J Oncol. 2009 Jan;34(1):281-6.
(4) Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. Li Y, Zhang T, Jiang Y, Lee HF, Schwartz SJ, Sun D. Mol Pharm. 2009 Jul-Aug;6(4):1152-9.
(5) Eppicatchin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. Kurbitz C, Heise D, Redmer T, Goumas F. Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A. Cancer Sci. 2011 Jan 17. doi: 10.1111/j.1349-7006.2011.01870.x. [Epub ahead of print]
About The Author:
Barbara is a published author and the managing editor for AlignLife as well as a student of nature and all things natural.
Also see:
http://www.curezone.com/forums/fm.asp?i=986525#i
http://www.curezone.com/forums/fm.asp?i=1608269#i
http://curezone.com/forums/fm.asp?i=1491846#i
It makes sense that green tea catechins would work for pancreatic cancer since this is another example of a viral induced cancer. And catechins are antiviral.
There is a possible link between the TT virus and pancreatic cancer:
http://www.wjgnet.com/1007-9327/11/2847.pdf
And pancreatic cancer has been linked to hepatitis B anc C viruses:
http://www.medscape.com/viewarticle/581493
http://www.news-medical.net/news/2009/01/13/44935.aspx
Isn't it quite the leap to say that pancreatic cancer is virally induced? I don't find that opinion to be prevalent at all among cancer authorities and the links you gave do not indicate that pancreatic cancer is a virally induced cancer, only that there may be some association between certain viruses and pancreatic cancer in some patients.
The first link said the they found the co-existence of TTV and pancreatic cancer in TWO cases and that it bore further investigation. The other two links merely addressed the issue of increased incidence of cancer for people who had Hep-B and Hep-C. Since people who have cancer almost always also have damaged livers, that would stand to reason - but does not in my opinion indicate in any way that pancreatic cancer is usually induced by viruses.
As a matter of fact, when you do a Google search for "pancreatic cancer causes", here is what you get in the first page of results:
http://pathology.jhu.edu/pc/BasicCauses.php
http://www.emedicinehealth.com/pancreatic_cancer/page2_em.htm
http://en.wikipedia.org/wiki/Pancreatic_cancer
http://www.wrongdiagnosis.com/p/pancreatic_cancer/causes.htm
http://www.medicinenet.com/pancreatic_cancer/page2.htm
http://www.webmd.com/cancer/pancreatic-cancer/causes-pancreatic-cancer
http://www3.mdanderson.org/DEPARTMENTS/pancreatic/qa/whatcauses.htm
http://www.mayoclinic.com/health/pancreatic-cancer/DS00357/DSECTION=causes
http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer...
Not one of those lists viruses among the causes of pancreatic cancer. John Hopkins, MD Anderson, Mayo - you'd think they would know enough to at least list viruses as one of the possible causes .
While catechins. especially those found in green tea, may have anti-viral properties they also have properties which inhibit the growth of cancer cells as well as prevent the activity of free radicals which cause cellular damage that can lead to cancer.
Isn't it quite the leap to say that pancreatic cancer is virally induced?
Not really. The research has proven this unlike the real stretched comment made by you in this post:
http://curezone.org/forums/fm.asp?i=1764381#i
where you claim that " most cancer is caused by poor cellular health plus toxins & radiation"
I don't find that opinion to be prevalent at all among cancer authorities
And I am sure the cancer authorities are just beating down the doors waning people that most cancers are caused by poor cellular heath, right? I am sure they would have a problem with the claim of toxins as well since this is pretty vague and they believe that many cancers are caused by hormones as well as radiation and pathogens.
and the links you gave do not indicate that pancreatic cancer is a virally induced cancer, only that there may be some association between certain viruses and pancreatic cancer in some patients.
Actually there is a shown link between the hepatitis viruses and pancreatic cancer. And as I have pointed out before there has never been any proof of hereditary cancers. Every oncogene that has been found was found to be viral. So it seems the cancer authorities know quite a bit more about cancer viruses than you.
The first link said the they found the co-existence of TTV and pancreatic cancer in TWO cases and that it bore further investigation.
That is why I said "possible link" with TTV.
The other two links merely addressed the issue of increased incidence of cancer for people who had Hep-B and Hep-C. Since cancer is more apt to occur in diseased tissue,
Any proof that cancer is more apt to occur in diseased tissues? I have never seen the cancer authorities make any such claim so apparently you must have read some studies I didn't.
As far as there only being an increase this is true, but a very significant increase.
that would stand to reason and does not in my opinion indicate in any way that pancreatic cancer is induced by viruses.
Of course you have argued that no cancers are viral in origin the past despite numerous studies over the last 100 years to the contrary. instead you think that cancer is caused from poor cellular health, which is a vague and unproven claim.
But tell me then how the catechins are treating the pancreatic cancer when there only effects as far as cancer goes is as an antiviral?
As a matter of fact, when you do a Google search for "pancreatic cancer causes", here is what you get in the first page of results:
http://pathology.jhu.edu/pc/BasicCauses.php
http://www.emedicinehealth.com/pancreatic_cancer/page2_em.htm
http://en.wikipedia.org/wiki/Pancreatic_cancer
http://www.wrongdiagnosis.com/p/pancreatic_cancer/causes.htm
http://www.medicinenet.com/pancreatic_cancer/page2.htm
http://www.webmd.com/cancer/pancreatic-cancer/causes-pancreatic-cancer
http://www3.mdanderson.org/DEPARTMENTS/pancreatic/qa/whatcauses.htm
http://www.mayoclinic.com/health/pancreatic-cancer/DS00357/DSECTION=causes
http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer...
Not one of those lists viruses among the causes of pancreatic cancer. John Hopkins, MD Anderson, Mayo - you'd think they would know enough to at least list viruses as one of the possible causes.
ROTFLMAO!!!! You would also think that they would know that ozone cures cancer and it would be all over their journals.
What I find most interesting is how I found all sorts of medical and science journals reporting the links between the viruses and pancreatic cancer within minutes. And you apparently did all sorts of research and found nothing. Tell you what. When I get done teaching you about cancer I will teach you how to do proper research if you want.
While catechins. especially those found in green tea, may have anti-viral properties they also have properties which inhibit the growth of cancer cells
Proof of this? And exactly how does it do this? By destroying cancer viruses?
as well as prevent the activity of free radicals which cause cellular damage that can lead to cancer.
Proof that free radicals cause cancer? Why is it that EVERYONE is exposed to free radicals every day and yet not everyone has cancer. You claimed that a double the increase in pancreatic cancer from hepatitis infections is a casual relationship, yet free radicals are present in 100% of the population and pancreatic cancer is still rare. For that matter cancers in general can be considered somewhat rare considering the number of cases in relationship to the world's population.
By the way, apparently you are also unaware that we need free radicals to survive and that the body's primary defense against malignancies is a free radical generated by the body. Know what this free radical is?
I have never once argued that NO cancers are caused by viruses, only that MOST cancers are not caused by viruses - which, despite all the studies and posts you refer to, is the opinion shared by the vast majority of people inside and outside mainstream medicine who deal with cancer.
Other than that, my only response to your post is this: If you want to debate cancer beyond a couple of posts where we set forth what our beliefs and positions are, we can do so in the Cancer Debate forum and not here in the support forum.
As you know, diseases such as cancer are mostly all about terrain and what is introduced into the terrain. That is why industrialized countries have seen such an increase in cancer - the toxic chemicals and the crap food we have, along with increased radiation exposure.
Granted, there are cancers in less develped countries too - but what do those countries often have in common? Poor nutrition and thus unhealthy cellular terrain and immune systems. Where you find less chemicals and plenty of good nutrient dense unadulterated food you find much lower incidence of cancer.
Have you ever noted how many of the chemical and food companies are behind cancer programs which direct attention and research away from toxins, toxic products, additives and crap foods such as those they produce?
See for example:
Breast Cancer Deception – Hiding the Truth beneath a Sea of Pink
While there certainly are viruses that can produce cancer and many viruses which have been assoiciated with increased incidence of cancer, I believe that in many instances it is the damage caused by viruses which leads to cancers which are associated with viruses - especially when those viruses are introduced into cellular terrain which is already compromised. Another way of looking at it is that when immune systems are not strong enough to beat back viruses they often are also not strong enough to beat back cancer and other illness - so naturally there would be an association between viruses and increased cancer incidence.
If there truly were compelling evidence that viruses cause most cancers, don't you think that vaccination-loving Big Pharma and mainstream medicine would be jumping all over the connection in order to produce a whole plethora of new anti-cancer vaccines? One can only shudder, given the horrors the HPV vaccine has produced.
I don't know the particulars, but I would imagine quite a bit of green tea. I know that up to 8-10 capsules of Inositol/IP6 is considered a good therapeutic dose for those with cancer. I personally would consider green tea a good cancer preventive and a good additon to an overal cancer fighting protocol. Inositol/IP6 can be used for both and, like many other items including oleander, can be very dose dependent against more difficult, more aggressive and more late stage cancers. I surely would not depend on just green tea and IP6 if I had pancreatic cancer, but I surely would include both of them among the items I did take.
This is really great info! so is this saying the pc was eliminated with these IP6 and green tea?
What I find so funny is that IP6 (inositol hexaphosphate, phytic acid) is finally being promoted for cancer by the anti-soy proponnets. The anti-soy proponnents call this an "anti-nutrient" incorrectly claiming it robs the body of minerals.
