I looked back to see that she's only on 12.5 mg Iodoral. With the breast pain returning, that suggests to me she ought to increase. If her body is now absorbing the iodine better, it's going other places than just her thyroid and breasts, and she probably needs the 50 mg to get things right. I'm thinking about the fullness she's feeling before she bleeds. Sounds like a bit of PMS, and since she's in her 40's she might be needing a little supplemental progesterone. Sometimes vit E (full spectrum) can also be useful for hormonal smoothing.
When I felt bogged down by Iodoral, because of the elemental, I added Trapper's SSKI, and I felt lightened. If your GF takes 2 drops and can feel a difference, then she can work on what her best ratio between the two would be. BTW, 2 drops (edit -- added to the 50 mg Iodoral) would put her within spittin' distance of 100 mg iodine/iodide.