I think depression is a complicated matter, the source of which varies from individual to individual. It can come from physical sources, emotional sources, and spiritual sources....such as having hostile entitites who have grudges against you from things you did to them in past lives attached to you and reeking havoc.
I have heard it said however, that in times of catastrophe or war, or any time survival is at stake, depression all but disappears...which would indicate there is a degree of self indulgence involved.