Blog: "Vaccines as a primary CAUSE of food allergies"
by llasidog

Can getting a vaccination cause an allergy?

Can getting a vaccination cause an allergy? Not cause an allergic reaction to the shot but cause a peanut allergy if the vaccine has peanut oil with minute traces of peanut protein in it?

Date:   1/18/2009 3:22:45 PM   ( 15 y ) ... viewed 3409 times

Can getting a vaccination cause an allergy?

I think this is an obvious item. Can getting a vaccination cause an allergy? Not cause an allergic reaction to the shot but cause a peanut allergy if the vaccine has peanut oil with minute traces of peanut protein in it?

First, let’s examine how a vaccine works.

http://www.immunisation.nhs.uk/Vaccines/Hib_Men_C/Vaccine/How_does_the_vaccine_work

The vaccine works by causing the body to produce its own protection (antibodies) against these bacteria.

Simple. The vaccine causes the body to create antibodies against the bacteria in the vaccine.

Ok, now let’s examine what an allergy is.

http://www.allernet.com/ALLABOUT/index.html

The allergy antibody (IgE) made by your immune system is produced in response to your exposure to substances we refer to as ALLERGENS. Allergens are usually environmentally stable foreign substances like pollen proteins that may induce unfortunate allergy immune reactions in predisposed individuals.

 

Is IgE important to the immune response? Or is it solely an allergic response?

http://www.sunstar.com.ph/static/bag/2005/01/16/oped/dr..vic.dumaguing.html

we have our antibodies, which are produced by so-called plasma cells. These antibodies are of the gamma globulin type proteins. Otherwise called immunoglobulins (Ig), they complement our white blood cells in combating infections. Thus, IgM or immunoglobulin M is the first antibody that would meet an invading microbe, together with neutrophil.

Likewise, the longer-lasting IgG takes over if the battle lasts longer. IgG is also the most common antibody our bodies produced in response to vaccination or immunization. Breast-fed infants get abundant supply of IgA from their mothers and also IgG while they were still inside the womb. IgE pairs with eosinophil in controlling parasitic infestations.

 

The Complete Idiot's Guide to Food Allergies by Lee H. Freude, M.D., and Jeanne Rejaunier, Penguin Group, 2003

pg 72 - "Most frequently the immunoglobulin involved is IgE. This reaction occurs in a very short period of time after eating the offending food, and is called an immediate reaction. Other reactions can involve IgG, IgM, IgA, and S-IgA. These can occur at a later time and are called delayed reactions."

Looks like IgE is important to the body’s immunity in controlling parasitic infestations. Couldn’t find anything else on the net about what IgE is supposed to do for the body. But it is a natural thing for the body to produce and important so we do want it. And it looks like there are many "Ig-type" responses. So only testing for IgE in the body would not tell you if the person has an allergy or not....

OK, now have there been any people or animal studies that showed a direct cause and effect between vaccine and food allergy?

The Complete Idiot's Guide to Food Allergies by Lee H. Freude, M.D., and Jeanne Rejaunier, Penguin Group, 2003

          pg 14:

"In 1839, the French physiologist Francois Magendie (1783-1855), while investigating the effects of substances on living organisms, created allergylike symptoms in animals, and found that animals sensitized to egg white by injection died after a subsequent injection."

"In 1901, French scientist Charles Richet (1850-1935) coined the word anaphylaxis to designate the sensitivity developed by an organism after being given an injection of protein or toxin."

pg 16:

"Working in Germany in the early part of the twentieth century, Prausnitz and an associate - experimented on themselves, and through injections, developed severe asthma and hives."

 

http://www.vran.org/vaccines/anaphylaxis/vaccine-ana.htm

Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid. It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases. PMID 707792

Pediatric Allergy Immunol 1994 May;5(2):118-23 Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines. The role of aluminum for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status………………the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response. The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role of immunization for the development of allergy merits further studies. PMID 808719

 

http://lrsitbrd.nic.in/IJTB/Year%201990/October%201990/october%201990%20D.pdf

A PILOT STUDY TO ASSESS POST VACCINATION ALLERGY INDUCED
AFTER BCG VACCINATION IN INFANTS VACCINATED BY AUXILIARY
NURSE-MIDWIVES IN AJMER (RAJASTHAN)
Yet, the observed mean size of post-vaccination allergy in both the groups was below 6 mm i.e. much lower than what could be expected. Since the maximum extent of post-vaccination allergy occurs three to four months following vaccination, the possible waning of allergy, if any, that could have occurred in the two to three months that elapsed after the target timing could not have been so profound.

 

http://www.chiroweb.com/mpacms/dc/article.php?id=31598

Do DTP and Tetanus Vaccinations Cause Asthma?
New Study Shows Vaccinated Children Twice as Likely to Get Asthma and Other Allergy-Related Symptoms
By Michael Devitt
A new study in the Journal of Manipulative and Physiological Therapeutics1 supports the findings of three previous studies that children who receive diphteria-tetanus-pertussis (DTP) or tetanus vaccines are more likely to have a “history of asthma” or other “allergy-related respiratory symptoms.” The study reviewed data from the Third National Health and Nutrition Examination Survey, which was conducted by the National Center for Health Statistics from 1988 to 1994.

 

http://www.vaccination.inoz.com/asthma3.html

Michel Odent20 found the frequency of asthma in a group of fully vaccinated children to be 11%, while a 1997 NZ study21 found 23%. Both found the frequency in the unvaccinated children to be only 0 – 1%. Several studies have found the rate higher after vaccines that use aluminum hydroxide as adjuvants in the postnatal period.22

Significantly, there was a decrease in deaths from asthma in the U.S. for some years until the DPT vaccine was mandated in the U.S. for school entry, in 1978. Since then, deaths from asthma23 and other immune disorders have been rising (as has also the reported incidence of whooping cough itself!).

20 JAMA 1994;272 (8): pgs 592-3, and Lancet 1994:344:140.
21 Epidemiology 1997 Nov 8:6 678-80
22 J Allergy Clin Immunol 1999;104:1128-30. Dec 1999; 104 Number 6
23 CDC MMWR reports (See Appendix B in Submission article on this web site)

http://content.karger.com/ProdukteDB/produkte.asp?

Aktion=ShowFulltext&ArtikelNr=112498&Ausgabe=234225&ProduktNr=224161
A Neonatal Swine Model of Allergy Induced by the Major Food Allergen Chicken Ovomucoid (Gal d 1)
Methods: In order to induce Ovm sensitivity, piglets at days 14, 21 and 35 of age were sensitized by intraperitoneal injection of 100 µg of crude Ovm and cholera toxin (50, 25 or 10 µg). Controls received 50 µg of cholera toxin in phosphate-buffered saline.

http://findarticles.com/p/articles/mi_m1200/is_/ai_104730216

Brandt and his colleagues induced an allergy to chicken eggs in a group of mice by injecting them with ovalbumin, an egg protein. Then they fed the mice ovalbumin, placed within coated pill-like beads to prevent the protein’s destruction in the stomach. The mice became unable to digest food, a sign that they were suffering a severe allergic reaction. A control group of mice that weren’t allergic to ovalbumin showed no signs of distress when fed the beads.

http://medical-dictionary.thefreedictionary.com/induced+allergy
definition: induced allergy
allergy resulting from the injection of an antigen,
contact with an antigen, or infection with a microorganism, as contrasted with hereditary allergy.

http://pt.wkhealth.com/

Inflammatory Responses in Skin and Airways after Allergen Challenge in Brown Norway Rats Sensitized to Trimellitic Anhydride.

Abstract:
Trimellitic anhydride (TMA) is a low-molecular-weight compound which causes occupational allergy. Brown Norway rats were sensitized to TMA injected intradermally (0.3% TMA suspended in oil). Three weeks later, we examined responses to either free TMA injected intradermally, or TMA conjugated to rat serum albumin (TMA-RSA) given by inhalation (0.5% nebulized for 15 min). Twenty-one days after the sensitization, …Sensitized animals showed significantly higher levels of specific IgG and IgE. We conclude that brown Norway rats can be used as a model of TMA-induced allergic inflammation, mimicking occupational asthma.
(C) 1996 Munksgaard International Publishers Ltd.

 

http://books.google.com/books

From preview of the book
Samter’s Immunologic Diseases
By Karl Frank Austen
In 1902, Charles Richet and Paul Portier reported that, whereas the extract from sea anemone tentacles had no effect on dogs when given as a single injection, a second injection after a few weeks caused arapid and fatal reaction. Richet gave the term anaphylaxis to this phenomenon suggesting that the initial injection of toxin had somehow weakened the dog’s defense mechanisms and increased its susceptibility to toxin on subsequent exposure.

 

http://www.vaccinetruth.org/peanut_oil.htm

Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and nonvaccinated children.
1. Original Article

Pediatric Allergy & Immunology. 19(1):46-52, February 2008.
Bernsen, Roos M. D. 1, 2; Nagelkerke, Nico J. D. 2; Thijs, Carel 3; van der Wouden, Johannes
C. 1
Abstract:
Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95% confidence interval (CI95%): 1.36-3.70], hay fever (OR = 2.35, CI95%: 1.46-3.77) and food allergy (OR = 2.68, CI95%: 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.

 

Egg-related allergy is common, particularly in children with asthma or general allergies, and may be as high as 40% in children with moderate to severe atopic dermatitis.21 The risk of egg-related allergy after vaccination depends on the presence of egg protein in the final product.

 http://www.vaccinetruth.org/peanut_oil.htm

Pediatrics 1988 Jun (81) Supplement - Report on the Task Force on Pertussis and Pertussis Immunization – extract states, For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.

Bull Eur Physiopathol Respir  1987;23 Suppl 10:111s-113s A model for experimental asthma: provocation in guinea-pigs immunized with Bordetella pertussis states, “ Guinea-pigs were sensitized with killed Bordetella pertussis………the presence of the immediate type of immune response was verified by passive cutaneous anaphylaxis……B. pertussis not only alters adrenergic function but provocation in B. pertussis-sensitized guinea-pigs seems to be a good model for bronchial asthma.  PMID 2889487

 Pediatr Res 1987 Sep;22(3):262-7 Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction……….the results of our experiments have established that the disease induced by coimmunizing mice with Ptx and BSA is due to an immediate type hypersensitivity…………PMID 3309858

 Infect Immun 1987 Apr.;55(4):1004-8 Anaphylaxis or so-called encephalopathy in mice sensitized to an antigen with the aid of pertussigen (pertussis toxin), states, Sensitization of mice with 1mg of bovine serum albumin (BSA) or chicken egg albumin (EA) ………….induced a high degree of anaphylactic sensitivity when the mice were challenged i.v. with 1 mg of antigen 14 days later.   PMID 3557617 

JAMA 1994 Aug 24-31;272(8):592-3 Pertussis vaccination and asthma: is there a link?

A study of 450 children, 11% of the children who had received the pertussis vaccination suffered from asthma, as compared with only 2% of the children who had not been vaccinated. [This does not tell you if the "unvaccinated children" had no vaccinations or just other vaccainations...- bfg]   PMID 8057511 

Allergy 1983 May;38(4):261-71

The non-specific enhancement of allergy. III. Precipitation of bronchial anaphylactic reactivity in primed rats by injection of alum or B. pertussis vaccine: relation of response capacity to IgE and IgG2a antibody levels.   …..These results show that injection of alum or B. pertussis vaccine without antigen can precipitate/enhance anaphylactic response capacity and production of specific and non-specific IgE and IgG2a.   PMID 6307077

 Allergy 1980 Jan;35(1):65-71 Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs.  Pattern of response in relation to immunization regimen….guinea-pigs sensitized with small amounts of antigen together with alum produced IgE and IgG1 antibodies.    PMID 7369497

 Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid.  It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases.   PMID 707792

 Pediatr Allergy Immunol 1994 May;5(2):118-23  Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines.  The role of aluminium for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status………………the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response.  The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role of immunization for the development of allergy merits further studies.    PMID 8087191

Adv Drug Deliv Rev 1998 Jul 6;32(3):155-172 entitled Aluminum compounds as vaccine adjuvants stated, “Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-Cell responses.    PMID 10837642

Annals of Asthma, Allergy and Immunology, Vol. 85, Number 1, July 2000 article T-cell subsets (Th1 versus Th2) includes Figure 7 on page 15 – “Factors responsible for the imbalance of the Th1/Th2 responses which is partly responsible for the increased prevalence of allergy in Western countries.  Risk for atopy - Th2, increased exposure to some allergens and Th2-biasing vaccines (alum as adjuvant).” 

Immunology Today, March 1998, Volume 19, p. 113-116 states, Modern vaccinations, fear of germs and obsession with hygiene are depriving the immune system of information input upon which it is dependent.  This fails to maintain the correct cytokine balance and fine-tune T-cell regulation, and may lead to increased incidences of allergies and autoimmune diseases.

From the journal Allergy 1999, 54, 398-399, Multiple Vaccination effects on atopy, “An increase in the incidence of childhood atopic diseases may be expected as a result of concurrent vaccination strategies that induce a Th2-biased immune response.  What should be discussed is whether the prize of a reduction of common infectious diseases through a policy of mass vaccination from birth is worth the price of a higher prevalence of atopy.”

Journal of Manipulative and Physiological Therapeutics, Feb. 2000; 23(2):81-90, Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States, The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects.  The odds of having any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects.”    PMID 10714532

Thorax 1998 Nov;53(11):927-32 Early childhood infection and atopic disorder, stated “Interpretation of the prediction of atopic disorders by immunisation with wholecell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation.  However, plausible immune mechanisms are identifiable for the promotion of atopic disorders by both factors and further investigation of these association is warranted.”  PMID 10193389

Epidemiology  1997 Nov;8(6):678-80 Is infant immunization a risk factor for childhood asthma or allergy?  This study followed 1,265 children born in 1977.  The 23 children who received no DPT and polio immunizations had no recorded asthma episodes or consultations for asthma or other allergic illness before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30% consultations for other allergic illness.  Similar differences were observed at ages 5 and 16 years.  PMID 9345669

 Arerugi 2000 Jul;49(7):585-92, The Effect of DPT and BCG vaccinations on atopic disorders findings include, “From these results we conclude that DPT vaccination has some effect in the promotion of atopic disorders…….   PMID 10944825

 

Agents Actions. 1976 Feb;6(1-3):75-85.

 


Adjuvant disease induced by mycobacteria, determinants of arthritogenicity.

Audibert F, Chedid L.

Genetic, endocrine and immunological factors are probably involved in adjuvant polyarthritis. The nature of the vehicle and of the mycobacterial components administered also has a major influence. It was originally assumed that arthritogenicity and adjuvanticity of mycobacterial fractions such as wax D were intimately related. Our previous findings showed that the water soluble adjuvant (WSA) of M.smegmatis which could substitute for mycobacterial cells in Freund's complete adjuvant and induce delayed hypersensitivity was not arthritogenic in the Wistar rat. We have since observed that auto-immune diseases could be elicited by WSA. Therefore experiments were repeated using the very susceptible Lewis strain. The activity of cord factor and of various mycobacterial preparations suspended in mineral or in peanut oil was also evaluated in mice and in normal or hypophysectomized rats. Our present findings confirm the absence of arthritogenicity of WSA in the Lewis strain. They also indicate that cord factor with WSA does not suffice to induce a generalized adjuvant disease, but that a mycobacterial component which could be susceptible to lysozyme treatment is required also. However, the local inflammation of the injected limb was produced by a preparation of cord factor administered in mineral or even in peanut oil. This was observed in normal or hypophysectomized rats and in Swiss mice which were not susceptible to the generalized disease.

PMID: 181972 [PubMed - indexed for MEDLINE]


http://www.eswi.org/Bulletin_April_1997.cfm

Potential Role for Adjuvanted Influenza Vaccine
Adjuvanted inactivated influenza virus vaccines (AIVV) were developed and administered to thousands of people during the mid-1940s and continuing to the mid-1970s. These studies demonstrated increased antibody responses and increased protection for AIVV when compared to aqueous vaccines and indicated that use of such vaccines could increase protection during interpandemic periods. Moreover, the enhanced immunogenicity obtained with lower doses suggested that the number of vaccine doses available for use against pandemic influenza could be considerably increased while still obtaining acceptable responses.

Increased immunogenicity for AIVV was reported in 1945; a four-fold enhancement of serum haemagglutination-inhibiting (HAI) antibody titres was seen when mineral oil was mixed with aqueous vaccine.

This finding was confirmed by others and the study of adjuvanted vaccines was then expanded. Most studies employed mineral oil or peanut oil (adjuvant 65, Merck & Co.) containing an emulsifier or an aluminium compound. The aluminium compounds varied in their immune-enhancing effects, but the two oil adjuvants consistently enhanced responses. Mean serum HAI antibody titres for two representative studies are shown in Table 1.

The magnitude of the increase (=>6­8 fold), the pattern for increase in all age groups including the elderly, the fact that results are similar for two type A subtypes, and that the greater response for adjuvant occurred with a lower antigen dose are of particular interest. Responses reported for influenza type A and type B viruses were similar. In one study, antibody was also measured in nasal secretions where frequencies of rises for AIVV increased from 47% to 78% and the geometric mean titre (GMT) from 0.4 to 1.0.

Thus, oil adjuvant vaccines can increase serum antibody significantly in all age groups when compared to comparable aqueous inactivated influenza virus vaccines. [In other words, they don't want to use a water-base adjuvant. So injecting you and your child with peanut will do a better job of making antibodies.... Do you really want the allergy and asthma antibodies?- bfg] Moreover, antibody increases in secretions appear to parallel those in serum. The overall antibody response has also broadened to include more related variants and to persist for up to three years. Early reactogenicity was increased for AIVV when given subcutaneously but reduced with intramuscular administration.

The enhanced immunogenicity of oil adjuvant vaccine was accompanied by enhanced protection. Using an A/Hong Kong (H3N2) virus challenge of volunteers, Freestone et al. [3] reported increased serum and nasal secretion neutralising antibody for a mineral oil adjuvant vaccine group (3500 HA unit dose) compared with aqueous split product vaccine at an 8000 HA unit dose. Virus shedding and illness after challenge were similar for split vaccine and controls but significantly lower for oil adjuvant vaccine. A summary of results from field trials with mineral oil adjuvant vaccine among USA military personnel is shown in Table 2.

Despite substantial increases in immunogenicity and effectiveness for oil adjuvant vaccines, their use was discontinued. [Maybe for a while they discontinuted using the mineral oil but they are definitely using peanut oil, soy oil, fish oil, and sesame oil. - bfg]  Reports of increased tumour formation in animals from mineral oil and Arlacel A (the emulsifier), and the occurrence of nodules, cysts, or sterile abscesses in a low proportion of recipients (3­23 per 10,000 vaccinees) were contributing factors. It is of interest that an 18-year follow-up of 18,000 oil adjuvant vaccinees did not reveal any increase in occurrences of cancer [5].

The recent development of a variety of experimental adjuvants and the burgeoning market for influenza virus vaccines has stimulated renewed interest in AIVV. Recent clinical trials have employed liposomes, monophosphoryl lipid A, Qs21 (active component of the saponin Quil A) and MF 59 (a synthetic adjuvant containing squalene). In experimental animals, significantly enhanced immunogenicity and efficacy have been observed for each of these; in humans, the response so far is only marginal. Clearly, the level of enhancement reported is considerably below that reported previously for oil adjuvant vaccine.

Improvements in the effectiveness of inactivated influenza virus vaccines, not only to enhance their performance but also to maintain and improve their reputation as a valuable preventive measure for influenza, are needed. Adjuvants can potentially enhance the effectiveness of current vaccines for both interpandemic and pandemic influenza. It is, therefore, important that efforts continue towards the identification of an adjuvant preparation that can approach the degree of enhancement conveyed in the past by oil adjuvant vaccines.

R.B. Couch
Department of Microbiology and Immunology
Baylor College of Medicine
Houston, Texas, USA

References

Hennessy AV, Davenport FM. Relative merits of aqueous and adjuvant influenza vaccines when used in a two-dose schedule. Public Health Rpts 1961; 76: 411­419.
Stokes J Jr, Weibel RE, Drake ME, et al. New metabolizable immunologic adjuvant for human use. N Engl J Med 1964; 271: 479­487.
Freestone DS, Hamilton-Smith S, Schild EC, et al. Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza viruses. J Hyg Camb 1972; 70: 531­543.
Davenport FM. Applied immunology of mineral oil adjuvants. J Allergy 1961; 32: 177­189.
Beebe GW, Simon AH, Vivona LS. Long-term mortality follow-up of army recruits who received adjuvant influenza virus vaccine in 1951­1953. Am J Epidemiol 1972; 95: 337­46.

 

 

Can J Comp Med. 1985 Apr;49(2):149-51. 

 Comparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swine. 

Straw BE, MacLachlan NJ, Corbett WT, Carter PB, Schey HM. 

Tissue damage caused by six different adjuvants incorporated in a Haemophilus pleuropneumoniae vaccine was compared in swine. The adjuvants compared were four mineral oil compounds, one peanut oil compound and aluminum hydroxide. Inoculations were given in the neck, quadriceps and semitendinosus muscles. The mineral oil adjuvants were highly irritant and caused extensive areas of granulomatous inflammation that were present at eight weeks after injection. The aluminum hydroxide produced smaller lesions that also persisted for eight weeks. Only the peanut oil adjuvant did not produce significant lesions at the site of injection. At two and four weeks, but not at eight weeks postinoculation, lesions in the quadriceps and semitendinosus muscles were approximately twice as extensive as those in the muscles of the neck.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_
uids=4016580&dopt=Abstract


 CAN VACCINE ADJUVANTS CAUSE ALLERGIES AND ANAPHYLAXIS?

 Requests for information on the types of adjuvants currently used in human vaccines have not been answered to date.  We did find that adjuvants are used to create allergic animals for scientific study and also that peanut oil has been used as an adjuvant.  Peanut is by far the most common food to cause anaphylaxis in young children.   Is peanut oil, or a similar protein or portion of a protein used in human vaccines as an adjuvant or “protein coat” in the Hib vaccine?   Aluminum has also been used as an adjuvant and is known to cause allergies according to the studies below.  Could the adjuvants used in vaccines over the last 15 years be creating anaphylactic and allergic children?

 

C/o Rita Hoffman, R. R. #2,

Stirling, Ontario  K0K 3E0  Canada

613-478-3236  pancakehill@sympatico.ca

 November 6, 2001

 Immunization Safety Review Committee, National Academy of Sciences

Institute of Medicine  FO 3009
2101 Constitution Avenue NW
Washington, D.C.  20418 

Dear Dr. McCormick, Chair & Committee,

Re:  Epidemic of Children with Anaphylaxis 

Thank you for the opportunity to submit the following information for your review of the possible association between multiple immunizations in newborns and infants and immune system dysfunction.  We are writing in particular about the potentially life threatening allergic response called anaphylaxis.    

The exact numbers of children affected by anaphylaxis are difficult to pinpoint.  A study in Arch Intern Med 2001 Jan 8;161(1):15-2, Anaphylaxis in the United States: an investigation into its epidemiology, concluded with “The occurrence of anaphylaxis in the US is not as rare as is generally believed.  On the basis of our figures, the problem of anaphylaxis may, in fact, affect 1.21% (1.9 million) to 15.04% (40.9 million) of the US population.”  PMID 11146694

 In June of this year an article by Associated Press Writer Jim Fitzgerald entitled Peanut Butter Wars Rage in Schools stated “Schools that haven’t had a dangerously allergic pupil can expect one soon.”  And “peanut allergies among schoolchildren were ‘barely on the radar’ a decade ago, said Dr. Robert Goldman, a New York allergist and Immunologist who specializes in pediatric cases.”  “Now I’m seeing a tremendous number of cases,” he said.  “It seems like the incidence is really increasing.  As to why, I don’t think anyone in the world could tell you for sure.” 

 In Canada, the Anaphylaxis Canada’s Summer 2001 newsletter states that “20% of Canadians suffer from some form of allergy and approximately 4% of children and 2% of adults have developed a potentially lethal allergy to food.”2

The cover story in the September 2000 issue of Professionally Speaking, the magazine of the Ontario College of Teachers is “An Abnormal Response to Normal Things.” The article begins with “Teachers have to be aware that allergies can kill.  A growing number of children are at risk – and a well-prepared teacher can make all the difference.”  The article explains that “About a decade ago, the sudden surge in highly allergic children entering school systems across the province caught many educators off guard.”  

Why the “surge” in anaphylactic children entering school a decade ago?   These children were among the first to receive an additional vaccination, Hib meningitis.  Is it possible that the Pertussis and Hib vaccine, both shown below to cause allergic responses, are creating a hypersensitive immune system in some children?  Has any study looked into what happens to atopy incidence and IgE levels when 5 vaccines are given concurrently in infants? 

CAN VACCINES CAUSE FOOD ALLERGIES?

JAMA 2001 Apr 4;285(13):1746-8 Detection of peanut allergens in breast milk of lactating women states, “Most individuals who react to peanuts do so on their first known exposure”……………..and concluded “Peanut protein is secreted into breast milk of lactating women following maternal dietary ingestion.  Exposure to peanut protein during breastfeeding is a route of occult exposure that may result in sensitization of at-risk infants."   PMID 11277829

 Women have been ingesting peanut protein while breastfeeding for decades.  What has changed in the last 15 years to cause infants to develop life-threatening allergies to this legume?  One change has been the vaccination schedule.

 The Int Arch Allergy Immunol 1999 Jul; 119(3):205-11 Pertussis adjuvant prolongs intestinal hypersensitivity concludes: Our findings indicate nanogram quantities of PT (pertussis toxin), when administered with a food protein, result in long-term senitization to the antigen, and altered intestinal neuroimmune function.  These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens.  PMID 10436392

 Does this study explain why babies and toddlers react on their first exposure to the peanuts or other antigens?  The babies may have been sensitized by the vaccines to the proteins through breast milk or formula ingested at the time of vaccination.  This would also explain why children are anaphylactic to a variety of proteins, such as different tree nuts, peanuts, egg, legumes, milk, seeds, etc., depending on what proteins the mother ate at the time of vaccination.  

 

IS THE INTRODUCTION OF THE HIB VACCINE CONNECTED TO THE INCREASE IN FOOD ANAPHYLAXIS IN CHILDREN?

 Rates of anaphylaxis have increased dramatically since the introduction of the Hib vaccine. 

 Clin Exp Pharmacol Physiol 1979 Mar-Apr;6(2):139-49 Comparison of vaccination of mice and rats with Haemophilus influenzae and Bordetella pertussis as models of atopy, states “The Haemophilus influenzae vaccinated experimental animal provides a model that is possibly more related to human atopy than the Bordetella pertussis vaccinated animal.”  PMID 311260

 Ann Allergy 1979 Jan;42(1):36-40 states “To determine whether Haemophilus influenzae could be a factor in human atopy its effects were studied on the (para-)Sympathic Cyclic nucleotide-histamine axis in rats.  Haemophilus influenzae vaccination induced changes in the cholinergic system compatible with higher cyclic GMP levels and enhanced histamine release.  The authors suggest an involvement of the cholinergic system in Haemophilus influenzae vaccination effects.  PMID 216288 

Agents Actions 1984 Oct;15(3-4):211-5  entitled Bronchial hyperreactivity to histamine induced by Haemophilus influenzae vaccination states “……This suggests a hyperreactivity of the parasympathethic, cholinergic pathways as a result of H.influenzae vaccination.”  PMID 6335351 

Eur J. Pharmacol  1980 Apr 4;62(4):261-8 entitled The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release states “These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. Influenzae vaccination.”  PMID 6154589

 DOES THE PERTUSSIS VACCINE CAUSE ASTHMA, ALLERGIES AND ANAPHYLAXIS?

 Pediatrics 1988 Jun (81) Supplement - Report on the Task Force on Pertussis and Pertussis Immunization – extract states, For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.4

 Pediatr Res 1987 Sep;22(3):262-7 Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction……….the results of our experiments have established that the disease induced by coimmunizing mice with Ptx and BSA is due to an immediate type hypersensitivity…………PMID 3309858

 Infect Immun 1987 Apr.;55(4):1004-8 Anaphylaxis or so-called encephalopathy in mice sensitized to an antigen with the aid of pertussigen (pertussis toxin), states, Sensitization of mice with 1mg of bovine serum albumin (BSA) or chicken egg albumin (EA) ………….induced a high degree of anaphylactic sensitivity when the mice were challenged i.v. with 1 mg of antigen 14 days later.   PMID 3557617 

 CAN VACCINE ADJUVANTS CAUSE ALLERGIES AND ANAPHYLAXIS?

 Requests for information on the types of adjuvants currently used in human vaccines have not been answered to date.  We did find that adjuvants are used to create allergic animals for scientific study and also that peanut oil has been used as an adjuvant.  Peanut is by far the most common food to cause anaphylaxis in young children.   Is peanut oil, or a similar protein or portion of a protein used in human vaccines as an adjuvant or “protein coat” in the Hib vaccine?   Aluminum has also been used as an adjuvant and is known to cause allergies according to the studies below.  Could the adjuvants used in vaccines over the last 15 years be creating anaphylactic and allergic children?

J Allergy Clin Immunol 2001 Apr;107(4):693-702 Murine model of atopic dermatitis associated with food hypersensitivity states, “Female C3H/HeJ mice were sensitized orally to cow’s milk or peanut with a cholera toxin adjuvant and then subjected to low-grade allergen exposure………………..An eczematous eruption developed in approximately one third of mice after low-grade exposure to milk or peanut proteins……………….This eczematous eruption resembles AD (atopic dermatitis) in human subjects and should provide a useful model for studying immunopathogenic mechanisms of food hypersensivity in AD.”  PMID 11295660

 Allergy 1980 Jan;35(1):65-71 Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs.  Pattern of response in relation to immunization regimen….guinea-pigs sensitized with small amounts of antigen together with alum produced IgE and IgG1 antibodies.    PMID 7369497

 Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid.  It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases.   PMID 707792

 Pediatr Allergy Immunol 1994 May;5(2):118-23  Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines.  The role of aluminium for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status………………the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response.  The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role of immunization for the development of allergy merits further studies.    PMID 8087191

Adv Drug Deliv Rev 1998 Jul 6;32(3):155-172 entitled Aluminum compounds as vaccine adjuvants stated, “Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-Cell responses.    PMID 10837642

Annals of Asthma, Allergy and Immunology, Vol. 85, Number 1, July 2000 article T-cell subsets (Th1 versus Th2) includes Figure 7 on page 15 – “Factors responsible for the imbalance of the Th1/Th2 responses which is partly responsible for the increased prevalence of allergy in Western countries.  Risk for atopy - Th2, increased exposure to some allergens and Th2-biasing vaccines (alum as adjuvant).” 

 ARE MULTIPLE VACCINES CAUSING OUR IMMUNE SYSTEMS TO FAIL?

Immunology Today, March 1998, Volume 19, p. 113-116 states, Modern vaccinations, fear of germs and obsession with hygiene are depriving the immune system of information input upon which it is dependent.  This fails to maintain the correct cytokine balance and fine-tune T-cell regulation, and may lead to increased incidences of allergies and autoimmune diseases.”

From the journal Allergy 1999, 54, 398-399, Multiple Vaccination effects on atopy, “An increase in the incidence of childhood atopic diseases may be expected as a result of concurrent vaccination strategies that induce a Th2-biased immune response.  What should be discussed is whether the prize of a reduction of common infectious diseases through a policy of mass vaccination from birth is worth the price of a higher prevalence of atopy.”

Journal of Manipulative and Physiological Therapeutics, Feb. 2000; 23(2):81-90, Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States, The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects.  The odds of having any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects.”    PMID 10714532

Thorax 1998 Nov;53(11):927-32 Early childhood infection and atopic disorder, stated “Interpretation of the prediction of atopic disorders by immunisation with wholecell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation.  However, plausible immune mechanisms are identifiable for the promotion of atopic disorders by both factors and further investigation of these association is warranted.  PMID 10193389

Epidemiology  1997 Nov;8(6):678-80 Is infant immunization a risk factor for childhood asthma or allergy?  This study followed 1,265 children born in 1977.  The 23 children who received no DPT and polio immunizations had no recorded asthma episodes or consultations for asthma or other allergic illness before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30% consultations for other allergic illness.  Similar differences were observed at ages 5 and 16 years.  PMID 9345669

 Arerugi 2000 Jul;49(7):585-92, The Effect of DPT and BCG vaccinations on atopic disorders findings include, “From these results we conclude that DPT vaccination has some effect in the promotion of atopic disorders…….   PMID 10944825

 International Archives of Allergy and Immunology 121:1:2000, 2-9, Genetic and environmental factors contributing to the onset of allergic disorders.   “The increasing prevalence of allergy in developed countries suggests that environmental factors acting either before or after birth also contribute to regulate the development of Th2 cells and/or their function.  The reduction of infectious diseases in early life due to increasing vaccinations, antimicrobial treatments as well as changed lifestyle are certainly important in influencing the individual outcome in the Th response to ubiquitous allergens.

 In conclusion, living with anaphylaxis is to be continually on guard for minute quantities of everyday food or other substances that may cause death.  Keeping anaphylactic children safe involves the whole community including the child, parents, teachers, bus drivers, caregivers, friends and family.   

It is our hope that the Committee will investigate the questions we have raised and will recommend further investigation into the connection between vaccines and this most distressing allergic disease called anaphylaxis.   

Your time is greatly appreciated. 

 Respectfully yours,

 Rita Hoffman

Anaphylaxis Action
R. R. #2, Stirling, Ontario K0K 3E0  Canada

613-478-3236    pancakehill@sympatico.ca 


 

Agents Actions. 1976 Feb;6(1-3):75-85.

 


Adjuvant disease induced by mycobacteria, determinants of arthritogenicity.

Audibert F, Chedid L.

Genetic, endocrine and immunological factors are probably involved in adjuvant polyarthritis. The nature of the vehicle and of the mycobacterial components administered also has a major influence. It was originally assumed that arthritogenicity and adjuvanticity of mycobacterial fractions such as wax D were intimately related. Our previous findings showed that the water soluble adjuvant (WSA) of M.smegmatis which could substitute for mycobacterial cells in Freund's complete adjuvant and induce delayed hypersensitivity was not arthritogenic in the Wistar rat. We have since observed that auto-immune diseases could be elicited by WSA. Therefore experiments were repeated using the very susceptible Lewis strain. The activity of cord factor and of various mycobacterial preparations suspended in mineral or in peanut oil was also evaluated in mice and in normal or hypophysectomized rats. Our present findings confirm the absence of arthritogenicity of WSA in the Lewis strain. They also indicate that cord factor with WSA does not suffice to induce a generalized adjuvant disease, but that a mycobacterial component which could be susceptible to lysozyme treatment is required also. However, the local inflammation of the injected limb was produced by a preparation of cord factor administered in mineral or even in peanut oil. This was observed in normal or hypophysectomized rats and in Swiss mice which were not susceptible to the generalized disease.

PMID: 181972 [PubMed - indexed for MEDLINE]


Distinctive Patterns of Autoimmune Response Induced by Different Types of Mineral Oil.

Kuroda Y, Akaogi J, Nacionales DC, Wasdo SC, Szabo NJ, Reeves WH, Satoh M.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610-0221, USA.

Although mineral oils are generally considered non-toxic and have a long history of use in humans, the mineral oil Bayol F (incomplete Freund's adjuvant, IFA) and certain mineral oil components (squalene and n-hexadecane) induce lupus-related anti-nRNP/Sm or -Su autoantibodies in non-autoimmune mice. In the present study, we investigated whether medicinal mineral oils can induce other types of autoantibodies and whether structural features of hydrocarbons influence autoantibody specificity. Three-month old female BALB/c (16-45/group) mice received an i.p. injection of pristane (C19), squalene (C30), IFA, 3 medicinal mineral oils (MO-F, MO-HT, MO-S), or PBS. Sera were tested for autoantibodies and immunoglobulin levels. Hydrocarbons were analyzed by gas chromatography/mass spectrometry. IFA contained mainly of C15-C25 hydrocarbons whereas MO-HT and MO-S contained C20-C40 and MO-F contained C15-C40. Pristane and n-hexadecane were found in IFA (0.17% and 0.10%, w/v respectively) and MOs (0.0026-0.027%). At 3 months, pristane and IFA induced mainly IgG2a, squalene IgG1, and MOs IgG3 and IgM in sera. Anti-cytoplasmic antibodies were common in mice treated with MO-F, as well as those treated with pristane, squalene and IFA. Anti-ssDNA and -chromatin antibodies were higher in MO-F and MO-S than in untreated/PBS, squalene, or IFA treated mice, suggesting that there is variability in the induction of anti-nRNP/Sm vs. -chromatin/DNA antibodies. The preferential induction of anti-chromatin/ssDNA antibodies without anti-nRNP/Sm/Su by MO-S and MO-F is consistent with the idea that different types of autoantibodies are regulated differently. Induction of autoantibodies by mineral oils considered non-toxic also may have pathogenetic implications in human autoimmune diseases.
 


 

 

J Vet Med Sci. 1992 Aug;54(4):685-92.

 


Pathological studies on local tissue reactions in guinea pigs and rats caused by four different adjuvants.

Yamanaka M, Hiramatsu K, Hirahara T, Okabe T, Nakai M, Sasaki N, Goto N.

Division of Veterinary Microbiology, Kyoto Biken Laboratories, Inc., Japan.

We investigated pathological changes at the injection site in guinea pigs and rats for 16 weeks following a single intramuscular injection of one of the following oil adjuvant emulsions; oil adjuvant ISA-70, Freund's incomplete adjuvant, Freund's complete adjuvant, and aluminium phosphate gel. In the animals injected with ISA-70 emulsion prepared by manual shaking, grossly, there was partial thickening of subcutaneous tissue, discoloration of inter-muscular connective tissue, and swelling of the inguinal lymph nodes at 2 and 4 weeks post injection (PI). Histopathologically, ISA-70 injected sites revealed acute inflammatory changes at 72 hrs PI, and peak reactions consisting of macrophage accumulation around oil cysts and fibrosis were observed at 4 weeks PI. These changes were less severe and of shorter duration than those in the other three adjuvants. Guinea pigs and rats injected with materials containing inactivated Newcastle disease virus (NDV) antigen similarly showed an infiltration of plasma cells and lymphocytes in addition to the changes described above. ISA-70 containing NDV antigen induced similar hemagglutination-inhibition titer to that induced by Freund's incomplete adjuvant.

PMID: 1391179 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_
uids=1391179&dopt=Abstract


www.thewest.com.au/20040428/news/general/tw-news-general-home-sto124001.html
 

Thousands of flu shots thrown out

CATHY O'LEARY - MEDICAL EDITOR

Thousands of ampoules of a new influenza vaccine due to be given to elderly West Australians this winter have been dumped after freezing on a flight to Australia. About 10,000 people were due to be given the vaccine Fluad, which is believed to be more effective than standard flu vaccines and therefore better for people with lowered immunity or chronic disease. But when the manufacturer Chiron was flying the vaccine from overseas laboratories to Sydney the shipment was accidentally frozen and had to be discarded.

WA Health Department communicable diseases branch medical director Tony Watson said he had been shocked to learn about the bungle last month. He was told Chiron could not guarantee the quality of the shipment so the Therapeutic Goods Administration could not approve it for use. Fluad is an adjuvanted vaccine which means viral particles are mixed with other substances to help boost immunity and offer wider protection against disease. WA doctors who were planning to give it their patients had been told to use the standard influenza vaccine instead.

"After a lot of planning it all fell in a heap which was very disappointing but there was no way the TGA could approve it and take any risk with it," Dr Watson said. "We were looking at providing it as part of the funded flu vaccination to selected high-risk people to gauge its acceptability in older people. The vaccine has been in use in Europe for five or six years and uses an oil-based adjuvant instead of an aluminium-based one.

"This means it produces more antibodies and provides protection for longer so is a stronger boost to the immune system. But the trade-off is that it can cause more reaction at the injection site." Dr Watson said it was too late to get extra stock of Fluad sent to Australia in time for the winter flu season. There was no guarantee the vaccine would be funded next season when a national tender would be called for flu vaccines.

Yesterday,Health Minister Jim McGinty launched this year's winter flu campaign, urging people aged over 65 and those with chronic disease to have their flu shot. He said that last year more than 1043 people were admitted to WA hospitals for flu treatment, about 12 per cent more than the number of cases in 2002.




http://www.mercurynews.com/mld/mercurynews/news/local/10162659.htm
San Jose Mercury News
Posted on Fri, Nov. 12, 2004

Food allergy vaccine promising
REACTIONS TO PEANUTS, WHEAT, MILK CURBED IN DOGS
By Esther Landhuis
Mercury News

It won't keep you from catching chickenpox, but a new vaccine developed by a Stanford-led research team could one day enable millions of food allergy sufferers to fearlessly bite into a peanut butter sandwich. Tested in dogs thus far, the vaccine curbs allergic reactions to peanuts, milk and wheat.

``What we're trying to create is an immune response that protects against allergies,'' said Dr. Dale Umetsu, the study's lead investigator and chief of the division of allergy and immunology at Lucile Salter Packard Children's Hospital at Stanford. His group describes its canine vaccines -- the first to block food allergies in an animal larger and more complex than a mouse -- in a paper published online today in the journal Allergy. The dogs in the study didn't start off with food allergies; the scientists manipulated their immune systems to mimic a human allergic response. Before getting vaccinated, the dogs could barely eat one peanut before breaking out in a skin rash. But 10 weeks after immunization, the animals devoured, on average, more than 37 peanuts before developing symptoms....

This idea led him to mix into his food allergy vaccines a secret ingredient -- dead bacteria -- hoping to trick the immune cells into responding as they would against a routine pathogen. The end goal is different, though. Most vaccines aim to boost the immune system so it can destroy the pathogen. However, food allergy vaccines are designed to spur an immune reaction that suppresses the overblown physiological responses of allergic individuals. Before the dog vaccines can be tested in people, the Food and Drug Administration requires additional experiments to test the vaccine's toxicity.

Food allergy sufferers are eager for relief. Oakland freelance writer Claudia Perry has a 5-year-old son whose peanut allergy is severe enough to trigger life-threatening anaphylaxis. ``It's something that's really hard to live with,'' Perry said. ``It's really scary that you have to be within 20 minutes of an emergency room. We're all hoping that the researchers find something.''

Contact Esther Landhuis at elandhuis@mercurynews.com or (408) 920-5458.

 


From Dorlands medical dictionary....

adjuvant (ad·ju·vant) (aj´ə-vənt, ă-joo´vənt) [L. adjuvans aiding]  1. assisting or aiding.  2. a substance that aids another, such as an auxiliary remedy.  3. in immunology, a nonspecific stimulator of the immune response, such as BCG vaccine.

Adjuvant 65  trademark for a water-in-oil emulsion containing antigen in peanut oil with Arlacel A and aluminum monostearate as the emulsifying agent. [Read this as "the peanut oil will not appear as an ingredient on the vaccine insert - bfg]

 

http://www.vaccinetruth.org/peanut_oil.htm

Conclusion:
I think it is very clear that a vaccination can cause an allergy.

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