Date:   1/24/2004 6:36:59 PM ( 21 y ago)
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Here’s some inside information on Candida and Leaky Gut prolems

From Progressive Health News
Jarrow Formulas releases “TH-1 Probiotics”
Vol. 3 No 2 February 1, 2000
By Mark Konlee - (Submitted to Curezone.com by Bruce D. McKay)

Butyrate - an over the counter supplement for LEAKY GUT SYNDROME - a condition found in all persons with HIV/AIDS, CFIDS, CANDIDA or candidiasis, chronic allergies, colitis, cancer and many other immune related disorders

My interest in butyrate was awakened last month when a reader with CFIDS reported taking the daily supplement and noticed an immediate improvement her gastrointestinal symptoms. In a healthy colon, butyrate is produced by bifido bacteria that ferment undigested carbohydrates like FOS and inulin. In a toxic colon, stool analysis of butyrate finds that it is consistently low.
As our analysis and logic dictates, restoration of a normal immune system first requires restoration of a healthy intestinal tract and strengthening of the mucus membranes, a prerequisite for restoring mucosal immunity. Restoration of a healthy gastrointestinal tract first requires two events - destroying infections like candidiasis and parasites that damage the mucus membranes and nutrients to rapidly rebuild the mucus membranes. Butyrate is one of the most important fuels for stimulating the growth of new mucus membranes in the intestines. Other substances include L-glutamine, vitamin A, cabbage juice (raw or cultured), buttermilk, kefir, horsetail herb and slippery elm tea. These can also be very helpful but are not a substitute for butyrate.

Butyrate is one of the short chain fatty acids produced by bifido bacterium (B Longum and others) in the large intestines. The growth of bifido bacteria is nourished by indigestible carbohydrates - Fructo Oligo Saccharides (FOS) and inulin, naturally occurring carbohydrates found in high fiber foods but especially in artichokes, CHICORY, onions, garlic, asparagus and bananas. A bowl of French onion soup or a large baked onion contains about 2 grams of FOS. I reported on the wide ranging benefits of FOS in last month’s message.
Eden Foods, manufacturers of “Bifa-15” a microencapsulated source of B Longum, report that as many as 400 different kinds of bacteria may inhabit the gastrointestinal tract. When the colon becomes the primary feeding ground of unfriendly flora like e-coli and candida, a condition called toxic colon develops and the pH of the colon becomes alkaline. Ammonia, amines and other toxins produced by unfriendly flora impair liver function and immune function more significantly than any other single factor we have discovered to date.

There is another factor to consider - substances like butyrate not commonly found in the diet are used as fuel by colonic cells to keep the intestinal membranes healthy and only the friendly flora, especially the bifido bacteria (i.e. B longum) produce butyrate. As a general rule, most of the unfriendly flora like pH that is alkaline while the friendly flora like an acidic colon. The unfriendly flora produce byproducts like ammonia that keep the colon alkaline while the friendly flora produce a variety of short chain fatty acids (lactic, acetic, proprionic, butyric and even formic acid) that keep the colon acidic. Thus a predominance of friendly flora create an environment that suppresses the bad bacteria. The reverse is also true - if most of the flora in your gut are unfriendly, they will kill off the friendly flora. This is indeed a war of microbes and we are in the middle of it. The food choices we make daily determines which side prevails - the good flora that keep us healthy or the bad that promote illness. Having a predominance of friendly flora in the colon is not an option for a healthy intestines, normal digestion and a strong immune system, IT IS A REQUIREMENT!


Note You can buy CALCIUM MAGNESIUM BUTYRATE at

http://www.phillypharmacy.com/buttab.html


Scientific research on Butyrate

Scientists have found that butyrates increase the production of mucin, a component of mucus, that provides a protective barrier throughout the entire gastrointestinal tract. (1) In experiments on rats, researchers found that three fibers, cellulose, pectin and gum arabic did not increase mucin production. They did find that glucuronic acid, a component of a variety of fibers, did significantly increase mucin production as did sodium alginate, acetate and butyrate. Both acetate and butyrate are byproducts of bifido bacteria fermentation of carbohydrates in the colon.
In animal experiments, scientists have found that butyrate hastens the repair of damage to the mucosal membranes of the colon induced by heat or detergents (2). [Note: Simply eating with silverware or dishes not properly washed and rinsed thoroughly, and especially pots and pains washed without a very adequate rinsing, may obviously play a major roll. The same may be accidently induced by way of careless or inappropriate use of antibacterial soaps. BDM] Scientists have found that butyrate helps prevent colon cancer and induces Glutathione S-transferase to detoxify carcinogens (3). Wheat bran was found to significantly increase butyrate levels (4).

In January, Cheryl Carter, a reader with CFIDS, told me she took 1 butyrate capsule with meals 3 times a day and noticed an immediate improvement in her gastrointestinal symptoms. Over the counter butyrate is available through Ecological Formulas or Allergy Research. It comes in the form of calcium butyrate and magnesium butyrate. It is relatively inexpensive. Ecological Formulas recommends 1 to 6 capsules with each meal.

Once you have a healthy colon and normal healthy stools (floaters) you will not need to take butyrate as a daily supplement. However, when your colon is toxic (sinkers, stinkers and small diameter stools) butyrate supplementation would be well advised. I would suggest 3 or more capsules with each meal along with supplements like caprylic acid to kill candida and back walnut to kill parasites for a month or longer or until you have normal healthy stools plus bright yellow urine (indicating B vitamin production from the bifido bacteria).

1. Barcelo A et al; Gut 2000 Feb;46(2):218-224
2. Venkatraman A et al; Scand J Gastroenterol 1999 Nov;34(11):1087-92
3. Kirlan WG et al; J Nutr 1999 Oct;129(10):1827-35
4. Compher CW et al; JPEN J Parenter Enteral Nutr 1999 Sep-Oct;23(5):269-77

Glucomannan nourishes bifidobacterium
increases HDL - lowers triglycerides

Research indicates that glucomannan, a fiber from the Konjac root strongly supports the growth of bifidobacterium as does FOS. Degradation of glucomannan by enzymes and friendly flora in human feces has produced formic acid, acetic acid, proprionic acid and 1-butyric acid. (1) Other researchers have found that glucomannan increases the good HDL cholesterol and lowers triglycerides (2)

In January, I tried an experiment on myself by taking 2 glucomannan capsules plus 2 FOS plus 2 Jarrowdophilus capsules. I found that within 2 to 3 hours, the urine was a deeper yellow color than taking FOS alone with the Jarrowdophilus. Deeper yellow urine is thought to be an indication of an increase in B vitamins produced in the colon by bifidobacterium and acidophilus. However, I found that by increasing the amount of FOS taken daily to about 6 grams (1/2 tsp 3X) I could get the color of the urine to be a bright yellow, without using the glucomannan. The color that healthy urine should be is bright yellow, not clear. Clear urine indicates an absence of friendly flora in the large intestines producing B vitamins. This self-test won’t work unless you stop taking B vitamin supplements for 24 hours to see if the urine is still yellow or goes back to being clear (an absence of B vitamins)

1. Matsura Y; J Nutr Sci Vitamiinol (Toyko) 1998 Jun:44(3):423-36
2. Venter CS et al; J Nutr 1990 Sep;120(9):1046-53

UPDATED INSTRUCTIONS ON USING FOS

Last month, I advised against using FOS with meals and recommended only using it with a fiber drink and probiotics taken all together. I am amending my instructions this month based on ongoing research. I have had reports of some persons who have been chronically ill for years who report they cannot tolerate FOS. I have discovered from published research that about 1 person in 25 absorbs some of the FOS into the blood and it is excreted in the kidneys. What this means is that these FOS absorbers have very severe leaky gut syndrome. The normal and even subnormal gut mucosa will not absorb FOS as the molecule is too large. The FOS then becomes food for the bifido bacteria and acidophilus in the colon. In about 4% of the population with severely damaged gut mucosa, absorption of the FOS occurs and this causes the problem of (FOS) “intolerance.”

The solution is for these persons to use high doses of butyrate first (in capsule form) 3 to 6 with each meal 3 or more times daily for about 2 weeks before introducing the FOS. The FOS can be introduced with either a fiber drink or a high fiber meal along with the probiotics like Vital Biotics or Jarrowdophilus. Start off with a small dose and gradually increase until you are using 4 to 6 grams daily.
During the first two weeks you are using the butyrate, try eating 1 cup of cooked onions daily or 1 large baked onion or 2 bowls of French onion soup. You can make your own with beef stock plus chopped onions. You can also use Miso in place of beef stock and make a miso-onion soup. You can top it with mozzarella cheese made from soy or rice milk. A cup of raw or cooked onions yields about 2 grams of natural FOS. The onions are high in sulfur compounds that will inhibit many kinds of pathogenic and unfriendly flora in the large intestines including fungus, yeast and many kinds of viruses.

Don’t forget to also include other sources of FOS like asparagus and artichokes. One tablespoon of artichoke flour contains about 1 gram (1000 mg) of FOS.

Note: if you use Bifa-15, you still need to take it by itself on an empty stomach. Several readers have highly praised this probiotic. It remains to seen how the B longum in the “TH-1 Probiotics” formula compares in effectiveness to the B longum in the Bifa-15 formula.

 

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