Hi I dont think there is anything wrong with taking the herabl tinctures. Schulze usually puts any warnings on his labels anyway. He has a lot of info on his site as well. If depression is the worst symptom start reading up on Dr john lee MD. He has a web site ((http://www.johnleemd.com/)) and has done enormous research on hormone balancing and has proved that most women are estrogen dominant over a low level of progesterone. He developed an organic formula that a few companies now do the cream. This company http://www.naturalpause.com/ does the best cream so I far found. quality and value for money. it would be hard to beat. Depression will ease if you read about everything they say, and do the changes in the diet.also depends on what other sympotoms there are as well.