Based on a review of the literature, and recent clinical research studies 2-13, the concept of orthoiodosupplementation can be summarized as follows:

1. The nutrient Iodine is essential for every cell of the human body requiring peripheral concentrations of inorganic Iodide ranging from 10-6M to 10-5M.

2. In non-obese subjects without a defecting cellular transport system for iodine, these concentrations can be achieved with daily intake of 12.5 mg to 50 mg elemental iodine. The adult body retains approximately 1.5 gm Iodine at sufficiency. At such time, the ingested Iodine is quantitatively excreted in the urine as iodide.

3. The thyroid gland is the most efficient organ of the human body, capable of concentrating Iodide by 2 orders of magnitude to reach 10-6M Iodide required for the synthesis of thyroid hormones when peripheral levels of inorganic iodide are in the 10-8M range.

4. Goiter and cretinism are evidence of extremely severe iodine deficiency, because the smallest intake of iodine that would prevent these conditions, that is 0.05 mg per day, is 1000 times less than the optimal intake of 50 mg elemental iodine.

5. The thyroid gland has a protective mechanism, limiting the uptake of peripheral iodide to a maximum of 0.6 mg per day when 50 mg or more elemental iodine are ingested. This amount therefore would serve as a preventive measure against radioactive fallout.

6. An intake of 50 mg elemental iodine per day would achieve peripheral concentration of iodide at 10-5M, which is the concentration of iodide markedly enhancing the singlet triplet radiationless transition. Singlet oxygen causes oxidative damage to DNA and macromolecules, predisposing to the carcinogenic effects of these reactive oxygen species. 5 This effect would decrease DNA damage, with an anticarcinogenic effect.

7. Preliminary data so far suggest that orthoiodosupplementation results in detoxification of the body from the toxic metals aluminum, cadmium, lead and mercury.

8. Orthoiodosupplementation increases urinary excretion of fluoride and bromide, decreasing the iodine-inhibiting effects of these halides.

9. Most patients on a daily intake ranging from 12.5 mg to 50 mg elemental iodine reported higher energy levels and greater mental clarity with 50 mg (4 tablets Iodoral), daily. The amount of iodine used in patients with Fibrocystic Disease of the Breast by Ghent et al20 is 0.1 mg/Kg BW per day, 10 times below the optimal daily intake of 50 mg. In our experience, patients with this clinical condition responded faster and more completely when ingesting 50 mg iodine/iodide per day.

10. For best results, orthoiodosupplementation should be part of a complete nutritional program, emphasizing magnesium instead of calcium.

11. A beneficial effect of orthoiodosupplementation was observed in the clinical conditions listed in Table I.5,7,12,13

12. The iodine/iodide loading test and serum inorganic iodide levels are reliable means of assessing whole body sufficiency for elemental iodine for quantifying the bioavailability of the forms of iodine ingested and for assessing cellular uptake and utilization of iodine by target cells.

13. Orthoiodosupplementation may be the safest, simplest, most effective and least expensive way to solve the healthcare crisis crippling our nation.

From:
http://www.newmediaexplorer.org/chris/2007/01/31/consequences_of_iodine_defic...