Hi there, Oh boy this makes me very sad. I'm not sure if it will help your friend at that late stage but hey, what could it hurt? I have been taking that remarkable therapy LDN for almost 3 years now to halt the progression of my MS and I am shouting it from the rooftops because I want all with auto immune disorders to get familiar with something that is not readily accessable information from doctors...YET!. Yes, I am prepared to attend the LDN conference in New York this June 11th where the doctor that worked with his theories about the endorphin producing therapy will be the keynote speaker. Anyone reading this should go and check out the information at www.ldninfo.org and do some research on this. This is no joke. None of us have any sort of time to waste. There are several in our yahoo group that are taking it for ALS and it is working for them. We take the Naltrexone at a very low harmless dose of 4.5mg. Very harmless. My doc says that it is almost homeopathic it is so low so he was happy to help me with a prescription. If you want any more info, please feel free to contact me at wkendz32@hotmail.com . I will do my best to help answer any questions you may have. There is hope for you...{{{hugs}}}. Believe me, when I started my research, I could only hope to find something to slow the progression of my MS and this did much more. It has been a miracle in my life and I sure hope you find your miracle. Godbless. Joyce