Even inside this forum the roll of copper in tissue repair is well documented.   Oral and topical forms of bioavailable copper have good documentation and sound research to not only demonstrate efficacy but also to explain it biologically.

Whether is be the cross linking of collagen with elastin,  whether it is angio genesis, the formation of new blood vessels,  copper has a roll in wrinkle prevention.

The real issue is bioavailability,  and the most common form of copper is copper 2.  This oxidized copper is poorly absorbed.

There is a copper 1, that is chelated with niacin and on the skin it reverses aging process.   I think the only thing needed in this protocol is oral vitamin c. 

Vitamin C,  it is precursor to collagen.  

This is an excellent video regarding the science and the studies that demonstrate the miracles of bio available copper. But also some true research links to demonstrate how well the supplement, if bio available can turn things around for you.

https://www.skininc.com/skinscience/ingredients/Copper-and-Its-Role-in-Collagen-Development-261314191.html

https://www.youtube.com/watch?v=QXVHQYF8WBc

or for direct link to the patent holder:   http://www.mitosynergy.com