Could be the issue I just found out I had. Insufficient folate.
B12 and iron did nothing for me and then I found out that too much ferritin and B12 covers up a more serious anemia caused by folate insufficiency.
Folic acid is a chemical poison. Don't take it ever again. Use methyl folate or folinic acid.
I got instant results.
It doesn't solve all the problems. Study the methylation process.

Sorry to hear about your list of problems.

Were other iron-related tests consistent with low iron?

Do you have symptoms consistent with it?

Do you have symptoms associated with low thyroid?

You might find this interesting.
http://www.wellnessresources.com/weight/articles/stunning_discoveries_regarding_iron_obesity_candida_thyroid/

Do you have gut problems similar to what is described in the article above?

One contributing factor to inflammation mentioned in the article is heavy metals. There is a theory that since iron is a heavy metal, the body tries to keep iron levels on the low side when there is a HM problem.

Of course mood/psych problems are associated with HMs, but people with a more than mild HM problem will have a much longer list of issues than you describe. The list posted by this member of a detox group is a good example of what a middle aged female might experience.
http://health.groups.yahoo.com/group/frequent-dose-chelation/message/111235

Did the doctor also test homocysteine?

Have you tried a combo of supplements that can take the edge off of anxiety--magnesium glycinate and or Epsom Salt, GABA, etc?

If you are middle aged, have you had an adrenal and sex hormone panel--progesterone, pregnenolone, etc?