Dr. Yamamoto first trialled GcMAF in the field of cancer with encouraging results, then repeated his successes with HIV. He published 4 papers showing 100% success rate with cancer & hiv but 3 of these papers were retracted in 2104 for what can only be described as nit-picking. The Science is sound and has been repeated by many other scientists in animal and in-vitro studies with over 150 research papers published.


Recently first pro engineering have produced high strength GcMAF. firstproengineering designed high strength Gcmaf sprays for sublingual use, this is in favor for people that do not know or like to inject themselves with Gcmaf. Gcmaf spray has been proven to be very successful for autism.


However it seems that the 15000ng spray is too strong for children with autism and there have been reports that some children react very strongly on gcmaf. There for first pro engineering developed a lower strength gcmaf spray that is suitable for children



Immune biotech has come on the market with Macact mouthwash which is based on Goleic. It comes in a dropper bottle, its intended for the mouth and for when low doses are required.

Although immune biotech does not sell Gcmaf it has been proven that the patented oleic acid is a effective macrophage activating substance.




What is GcMAF?
GcMAF (Gc Protein derived Macrophage Activating Factor) occurs naturally in our bodies and instructs macrophages to destroy cancerous cells and foreign invaders by activating them.

What are macrophages?
Macrophages (Greek: big eaters) are cells originating from monocytes, a type of white blood cell found in the body. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals.



Their role is to phagocytize (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion.



How does GcMAF work?

GcMAF works by activating macrophages. They are the major phagocytic and antigen presenting cells. Phagocytic means that they take up particles, not only dead cells and bacteria, but also toxic waste. They then present this foreign substance to other immune cells such as T cells, so that the whole immune system is notified of the invader. In the first step with antigen presenting to B and T lymphocytes, they play a role in the development of both the humeral (Th2), which is where the antibodies are made, and the cellular immunity called Th1.

Thus a lack of macrophage activity leads to immunosuppression across the whole immune system and it can be compared to a strike of the bin collectors. After a while the mess backs up and there is no getting away from the bacteria and dirt, and after a few months there is a huge problem. Using injectable GcMAF is a bit like giving the bin men a payrise and getting the cleaning up back on track.
In a healthy immune system, microbial infection creates inflammation, which results in macrophage activation as an innate defense. As the first line of defense, the macrophages play an important role. So when an inflamed tissue is given lipid metabolyte lysophosphatidychlorine, it activates macrophages. We call it LPS – lycopolysaccharides and these kind of substances, they activate macrophages, so if you have, for example, bacteria, this will activate the macrophages to become phagocytic. Inflammation derived macrophage activating process requires a Gc protein. Gc protein is a vitamin D binding protein.



Vitamin D Binding Protein



What is Vitamin D Binding Protein (VDBP)?
[4] Vitamin D Binding Protein is a multi-functional plasma protein with many important functions. The most well known one, and the reason for its name, is the transport of vitamin D metabolites . Because VDBP is the primary transporter of vitamin D, it has a role in maintaining the total levels of vitamin D in the body and in regulating the amounts of free (unbound) vitamin D available for specific tissues and cell types to utilise.
Other functions of VDBP are to control bone development, binding of fatty acids, sequestration of actin and a range of less-defined roles in modulating immune and inflammatory responses. The actin removal is considered to be a very important role for VDBP, actins being toxic and released into the body following cell death.
Two amino acids on this protein chain have been shown to be very strongly associated with the activation of macrophages. In some publications, the vitamin D binding protein is shown to respond to enzymes released by inflammation and this is often referred to as MAF (Macrophage Activating Factor). Studies show that this isoform not only activates macrophages, it turns them off when no longer needed, so it is an immune system regulator.
Studies in laboratory cultures have shown that Calcitriol (Vitamin D bound with VDBP) can significantly increase the number of dopamine neurons.