Get cooking with turmeric/Curcumin - http://newhope360.com/blog/curcumin-effective-drug-ra-sufferers-study-shows?c...


As more research shows the connection between inflammation and many diseases—from cancer to cognitive decline—it’s increasingly important that researchers continue to explore ingredients that promote a healthy inflammatory response.

A recent human clinical trial published in the March 2012 edition of Phytotherapy Research, demonstrated that BCM-95, a highly bioavailable form of curcumin, was as effective in alleviating symptoms of rheumatoid arthritis (RA) as diclofenac sodium (branded Voltaren, a leading pharmaceutical NSAID treatment).

The single-blinded pilot study was designed to determine whether twice daily supplementation with 500mg capsule of curcumin separately and in combination with diclofenac sodium (50mg) for eight weeks would improve Disease Activity Scores in patients diagnosed with active RA.

Forty-five participants were randomized to three groups (curcumin only, curcumin in combination with diclofenac sodium and diclofenac sodium only) and after eight weeks of therapy their DAS scores were reassessed along with the American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joints.

The BCM-95 curcumin group experienced the most improvement, though the score change wasn’t sufficiently higher than the combination and drug-only scores to call it an out-and-out winner, explained Cheryl Myers, chief of scientific affairs and education at EuroPharma, makers of CuraMed which uses BCM-95 to promote a healthy inflammation response.

Nonetheless, “the findings of this study are significant, as these demonstrate that curcumin was not only safe and effective, but was surprisingly more effective in alleviating pain compared with diclofenac,” wrote the study authors Binu Chandran and Ajay Goel.

Victory for curcumin

What we can deem an out-and-out victory, however, is that in the BCM-95 curcumin group there were no drop outs due to adverse effects, but in the diclofenac sodium (NSAID) group, 14 percent withdrew due to adverse effects.

According to Myers, as many as 20,000 Americans die each year from the negative effects of NSAIDs—ulcers, stomach bleeding, kidney function disruption and intestinal bleeding, to name a few. The indication that BCM-95 curcumin might offer a safer and equally as effective alternative to drug treatment should not only offer hope to RA sufferers, but inspire further research on this important ingredient.

“Our observations that curcumin alone was able to alleviate symptoms of rheumatoid arthritis in this study are quite encouraging, and these results provide an ideal springboard for investigating the potential of curcumin in other chronic diseases arising in the setting of dysregulated chronic inflammation,” wrote Chandran and Goel. 

How many scientific studies on the benefits of Curcumin/Turmeric does it take before someone adds this spice to their daily diet?

Here's another one on it's ability to restore and preserve neurological function in people with spinal cord injury -
http://www.sciencedaily.com/releases/2012/06/120626113930.htm


UCLA researchers discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient in curry spice preserved walking ability in rats with spinal-cord injury. Published June 26 in the Journal of Neurosurgery: Spine, the findings suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.

"Normal aging often narrows the spinal canal, putting pressure on the spinal cord and injuring tissue," explained principal investigator Dr. Langston Holly, associate professor of neurosurgery at the David Geffen School of Medicine at UCLA. "While surgery can relieve the pressure and prevent further injury, it can't repair damage to the cells and nerve fibers. We wanted to explore whether dietary supplementation could help the spinal cord heal itself."

The UCLA team studied two groups of rats with a condition that simulated cervical myelopathy -- a progressive disorder that often occurs in people with spine-weakening conditions like rheumatoid arthritis and osteoporosis. Cervical myelopathy can lead to disabling neurological symptoms, such as difficulty walking, neck and arm pain, hand numbness and weakness of the limbs. It's the most common cause of spine-related walking problems in people over 55.

The first group of animals was fed rat chow that replicated a Western diet high in saturated fats and sugar. The second group consumed a standard diet supplemented with docosahexaenoic acid, or DHA, and curcumin, a compound in turmeric, an Indian curry spice. A third set of rats received a standard rat diet and served as a control group.

Why these supplements? DHA is an omega-3 fatty acid shown to repair damage to cell membranes. Curcumin is a strong antioxidant that previous studies have linked to tissue repair. Both reduce inflammation.
"The brain and spinal cord work together, and years of research demonstrate that supplements like DHA and curcumin can positively influence the brain," said coauthor Fernando Gomez-Pinilla, professor of neurosurgery. "We suspected that what works in the brain may also work in the spinal cord. When we were unable to find good data to support our hypothesis, we decided to study it ourselves."

The researchers recorded a baseline of the rats walking and re-examined the animals' gait on a weekly basis. As early as three weeks, the rats eating the Western diet demonstrated measurable walking problems that worsened as the study progressed. Rats fed a diet enriched with DHA and curcumin walked significantly better than the first group even six weeks after the study's start.

Next, the scientists examined the rats' spinal cords to evaluate how diet affected their injury on a molecular level. The researchers measured levels of three markers respectively linked to cell-membrane damage, neural repair and cellular communication.

The rats that ate the Western diet showed higher levels of the marker linked to cell-membrane damage. In contrast, the DHA and curcumin appeared to offset the injury's effect in the second group, which displayed equivalent marker levels to the control group.

Levels of the markers linked to neural repair and cellular communication were significantly lower in the rats raised on the Western diet. Again, levels in the animals fed the supplemented diet appeared similar to those of the control group.

"DHA and curcumin appear to invoke several molecular mechanisms that preserved neurological function in the rats," said Gomez-Pinilla. "This is an exciting first step toward understanding the role that diet plays in protecting the body from degenerative disease."

"Our findings suggest that diet can help minimize disease-related changes and repair damage to the spinal cord," said Holly. "We next want to look at other mechanisms involved in the cascade of events leading up to chronic spinal-cord injury. Our goal is to identify which stages will respond best to medical intervention and identify effective steps for slowing the disease process."