GetCuredOrDieTrying
I only get mild flushing from 1000mg & it gets less with time... however, major fatigue that makes me lie down on the couch. Its a potent vasodilator.
Usual dose for cholesterol, 3000 mg per day.
I have read that in the 1950's they treated schizophrenia with up to 30 grams per day.
The study in mice used 500mg per KG body weight of the niacinamide. With some drugs, this ratio is adjusted downwards by a factor of 10 or so in humans, to account for slower metabolism.