I noticed good effects the very first night I used the cream. My insomnia and anxiety were gone and it was magical. Very soon after, within 3 weeks, my IBS, remaining dry eye, and Heartburn were also gone (which finally made the case for me that these were related to hormones, rather than an infection that my doctor was trying to treat). Every woman is different, as we all know, but a very low dose of P-Cream had dramatic effects for me.

However, as you may have read in my previous posts, over time I had an extremely adverse reaction to Progesterone cream. Yes, I did use pharmaceutical grade bioidentical prescribed by a doctor. I used it for a little over 3 months and developed side effects that I am still dealing with a year later, though a few of them are slowly fading.

Watch out for:
increased brain fog
fatigue
weight gain

(these are general)

My problems seemed to be very individual. The fatigue and brain fog are still the worst, and still there. I also had urinary problems (felt like I had a UTI from last Jan-Present, though now is much milder), and dizziness. Also, increased susceptibility to illness and infection. Progesterone is a natural steroid, which means it suppresses immunity. None of these, except for immunity, were mirena problems for me. Unfortunatly, it looks as though my natural progesterone production has actually decreased since using the cream, and my adrenals are a total mess based on urine/saliva testing.

Use with caution. Other women have a similar story to mine = feel good initially then go downhill. A good place to look for possible early side effects is: http://www.askapatient.com/viewrating.asp?drug=9238&name=PROGESTERONE


Which is a board where patients rate side effects of progesterone cream.

Some women have no problem with it, and only feel better. I hope this is you, but keep a watchful eye!