What would you consider "high doses"?

Lam's patients max out at 1200 mg. of pantethine.

I would consider 1200mg daily too much if not being balanced out with the other B vitamins since as I pointed out high levels of individual B vitamins displace others leading to problems. This more is better philosophy is the same as the pharmaceutical thinking.  If people really want to go with this kind of reasoning then why don't they just stick to pharmaceutical drugs? Of course it could be argued they are since most synthetic supplements are made by pharmaceutical manufacturers.

But I like how Ray Sahelian, MD puts it:

http://www.raysahelian.com/pantethine.html

"Pantethine supplement emails

Q. I wonder why you suggest that 25 to 50 mg of pantethine may be sufficient when the study you cite used 600 mg to reverse fatty liver.
   A. We have learned from experience that high doses cause side effects. Researchers do a study for a brief period of time, but when the consumer takes these high dosages for prolonged periods, problems could occur or the biochemical system of the body may go out of balance."

Again, taking high doses is just trading one problem for another problem.