'Iodine allergy' is not an accurate label for patients who have had allergic reactions to iodinated radiological contrast media or iodinated antiseptics. Allergy to seafood has nothing to do with iodine content as it is caused by specific immunoglobulin E to proteins. Seafood allergy is not a specific risk factor for reactivity to iodinated radiological contrast media, but a history of any moderate or severe allergic disorder confers a slight increase in risk. Patients with a previous history of allergy to radiological contrast media are at highest risk of a reaction. In some cases the risk of an allergic reaction to contrast media can be reduced by premedication, but, if previous reactions were severe, contrast media will usually remain contraindicated.
 

http://www.australianprescriber.com/magazine/32/5/125/8/

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