Keep in mind that you have to stick to the treatment for a while before you see results because it takes time to get trimethylamine out of your system.

Websites:

http://www.genetests.org

then click on Gene Reviews, and search for Trimethylaminuria under the Search by Disease engine, and finally under Reviews you'll find a wealth of information.


http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682338.html



http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682338.html


Here's another website:

http://rarediseases.info.nih.gov/GARD/QnA.aspx?PageID=4&CaseID=20839&DiseaseI...



In case you can't read it in this message, just go to

http://rarediseases.info.nih.gov


Then click on Rare Diseases and Related Terms under Rare Diseases Information. Look for Trimethylaminuria, and see Questions & Answers. Click on the 2nd question, "I think I may have trimethylaminuria. I would like more information that could be shared with my doctor that could help my doctor in diagnosing the condition." and then on "What treatment is available for trimethylaminuria?" and "Can trimethylaminuria be cured by replacing FMO3, the enzyme, which when absent, is believed to cause the condition?"
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http://www.genetests.org

then click on Gene Reviews, and search for Trimethylaminuria under the Search by Disease engine, and finally under Reviews you'll find a wealth of information.

I've also been doing so much research for such a long time, that I tend to not remember where I have all my records. Some of the info below comes from other online sources as well. Also, I have done a great deal of research and noted the references of each, and much to my great pleasure, I see that alot of these websites are being updated with more specific remedies with exact dosages and length of treatment time. In addition to a low-choline diet, here is the info my son goes by, and you have to be patient because it takes time for your system to clean out the trimethylamine:

1. RIBOFLAVIN (Vitamin B2) SUPPLEMENTS: 30-40 mg three to five times per day with food to enhance residual FMO3 enzyme activity. Enhancement of residual FMO3 enzyme activity with Supplements of riboflavin, a precursor of the FAD prosthetic group of FMOs, may help maximize residual FMO3 enzyme activity.

2. Sequestering of trimethylamine produced in the gut:
• Activated Charcoal: 750mg twice daily for 10 days
• Copper Chlorophyllin: 60mg three times/day after meals for 3 weeks

3. LAXATIVES, such as LACTULOSE as needed: decrease intestinal transit time may reduce the amount of trimethylamine produced in the gut. Be careful because you don't want to have accidents in the wrong places. Don't overdo it to become dehydrated with diarrhea. A simple intestinal cleansing every once in a while helps. I'll send you alot more info on this in a following message. Here's some info on LACTULOSE. I got this info from

http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682338.html


4. Suppression of intestinal production of trimethylamine: A short course of Antibiotics to modulate or reduce the activity of gut microflora, and thus suppress the production of trimethylamine. Such treatment may be useful when dietary restriction needs to be relaxed (e.g., for important social occasions), or when trimethylamine production appears to increase (e.g., during infection, emotional upset, stress, or exercise)

5. Antibiotics recommended for trimethylaminuria to suppress production of trimethylamine by reducing bacteria in the gut:
• neomycin – appears to be the most effective in preventing formation for trimethylamine from choline
• metronidazole
• amoxicillin

6. Using soaps with a moderate pH, between 5.5 and 6.5. Trimethylamine is a strong base (pH 9.8), thus soaps with pH closer to that of normal skin help retain the secreted trimethylamine in a less volatile form that can be removed by washing. Here's some info on LACTULOSE. I got this info from

http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682338.html.
Note how most tend to raise the pH of the skin, and if you have TMAU, the goal is to lower it to a healthy skin pH of 5.5 - 6.5. The normal skin pH is 5.5-6.5, which is a little acidic, and trimethylamine is very alkalosis. So, it stands to reason that the goal is to get the alkalosis down to the normal skin pH by using soaps that are closer to the normal skin pH – and to use them regularly, especially after perspiring. Here is a good website that has info on skin cleansers.

http://www.skintherapyletter.com/2003/8.3/1.html.
A chart in this website indicates that soaps, superfatted soap and beauty bars, dermatologic bars/cakes, and antiseptic and antibacterial washes tend to raise the pH of the skin. It states that cosmetic liquid cleansers generally have a pH similar to skin. It’s best to call the various cosmetic companies like Olay, Loreal, Neutrogena, etc., and ask them what the pH is on their cleansers.

pH factors:
Trimethylamine is a strong base (pH 9.8)
Normal skin pH is 5.5 – 6.5
Alcohol has low pH (pH 2 in aqua)
Acidosis < 7; alkalosis > 7.5

Hope this helps!
mpdela