Ketogenic Diet Prevents Seizures By ... 
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Ketogenic Diet Prevents Seizures By Enhancing Brain Energy Production, Increasing Neuron Stability
ScienceDaily (Nov. 15, 2005) — Although the high-fat, calorie-restricted ketogenic diet (KD) has long been used to prevent childhood epileptic seizures that are unresponsive to drugs, physicians have not really understood exactly why the diet works. New studies by a research team at Emory University School of Medicine show that the diet alters genes involved in energy metabolism in the brain, which in turn helps stabilize the function of neurons exposed to the challenges of epileptic seizures. This knowledge could help scientists identify specific molecular or genetic targets and lead to more effective drug treatments for epilepsy and brain damage.
See also:
Health & Medicine
* Epilepsy Research
* Diet and Weight Loss
Mind & Brain
* Epilepsy
* Dieting and Weight Control
Plants & Animals
* Genetics
* Biology
Reference
* Seizure
* Encephalopathy
* Ketone bodies
* Anticonvulsant
The research will be presented at the annual meeting of the Society for Neuroscience in Washington, D.C. by Kristopher Bough, PhD, a postdoctoral student in the laboratory of Emory pharmacology professor Raymond Dingledine, PhD.
"These findings support our hypothesis that a dietary regimen can dramatically affect the expression of genes and the function of neurons within the brain, which enhances the ability of these neurons to withstand the metabolic challenges of epileptic seizures," Dr. Dingledine said.
The ketogenic diet causes molecules called ketone bodies to be produced as fat is broken down. Scientists have understood that these molecules somehow cause a change in metabolism leading to a potent anticonvulsant effect. According to some animal studies they also may limit the progression of epilepsy.
The Emory research team studied the link between diet and epileptic seizures on the behavioral, cellular and genetic level. They found, as had others, that in rats fed the KD the resistance to seizures develops slowly, over one to two weeks, in contrast to rats treated with conventional anticonvulsant drugs. On the cellular level, they found that the anticonvulsant effect of the ketogenic diet did not correlate with a rise in plasma ketone levels or with a decrease in plasma glucose. Because longer treatment with the KD was necessary to increase the resistance to seizures, they concluded that changes in gene expression might hold the key to the diet's anticonvulsant effects.
To identify which genes might be involved, the researchers used microarray "gene chips" to examine changes in gene expression for more than 7,000 rat genes simultaneously. They focused on the hippocampus, a region of the brain known to play an important role in many kinds of epilepsies. More than 500 of the genes they examined were correlated with treatment with the KD. The most striking finding was the coordinated up-regulation of genes involved in energy metabolism.
To explain this genetic effect, the scientists first eliminated the possibility that the KD diet might cause enhanced production of GABA, a chemical messenger in the brain that helps limit seizure activity. They found that GABA levels in the hippocampus were unchanged with the KD.
To test whether energy reserves in hippocampal neurons were enhanced with the KD, they counted the number of energy "factories," or mitochondria, within cells using electron microscopy. They found that KD treatment significantly increased the number of mitochondria per unit area in the hippocampus. This finding, along with the concerted increase in the expression of genes encoding energy metabolic enzymes, led them to conclude that KD treatment enhances energy production in the hippocampus and may lead to improved neuronal stability.
Finally, the researchers tested whether brain tissue affected by the KD would be more resistant to low levels of glucose (an effect of seizures) because of their enhanced energy reserves. They found that synaptic communication in KD-fed rats was more resistant to low glucose levels than in control animals fed a regular diet.
The researchers believe their new knowledge could lead to the development of more effective drug treatments for epilepsy and brain damage.
And because the diet enhances the brain's ability to withstand metabolic challenges, they also believe the ketogenic diet should be studied as a possible treatment for other neurodegenerative disorders such as Alzheimer's or Parkinson's diseases.
Adapted from materials provided by Emory University Health Sciences Center.
http://www.sciencedaily.com/releases/2005/11/051114220938.htm
- Re: Ketogenic Diet Prevents Seizures... Dquixote1217
17 y
4,540
This is a reply to # 1,051,027
Good post - I am glad to see that you did not identify the Atkins diet as the preferred ketogenic diet, even though it is by far the most popular version of the diet. Dr. Atkins in fact pioneered studies into the benefits of the ketogenic diet and these later became the basis for the famous Atkins fad diet which came to be marketed as a diet where you could basically eat all the animal fats, other fats and even junk food you wanted so long as you elminated carbohydrates.
Initially a great many people, including mainstream medicine, jumped aboard the bandwagon of such an appealing diet. However, as time went by reality sunk in and an increasing number of studies began to indicate long term damage risks associated with a diet that restricts all carbohdrates.
This appeared to be borne out when Dr. Atkins autopsy revealed that he was obese, had suffered a heart attack, had atherosclerosis, coronary artery disease, and had high blood pressure, later hushed up and given the spin-doctor treatment by the Atkins family and empire. This attempt at coverup was countered almost immediately by then New York Mayor Michael Bloomberg, who announced ""I don't believe that %¤#&!§-that [Atkins] dropped dead slipping on the sidewalk." The 61-year-old billionaire added that Atkins was "fat" and served "inedible" food at his Hamptons home when Bloomberg visited. The mayor's inference, of course, was that Atkins was actually felled by his meat-heavy diet, that his arteries were clogged with beef drippings.
The simple fact is, some carbohydrates are essential for good health. So long as that is kept in mind, the ketogenic diet approach could be a good one.
For more information on the dangers of the Atkins diet::
http://www.atkinsdietalert.org/advisory.html
http://www.weightlossresources.co.uk/diet/atkins_diet/atkins.htm
or simply do a Google search on "Atkins Diet Dangers". You will find no shortage of information!
Live long, live healthy, live happy!
DQ (aka Tony Isaacs)
- Re: Ketogenic Diet Prevents Seizures... #89280
17 y
4,096
This is a reply to # 1,051,101The major problem with the Atkins diet is nobody read the books! They saw the infomercials and read the hype and assumed it was all fat for all the time one was on the diet.
Those who read the books know the induction phase which lasted only two weeks or so and was the period where people lost wight fast became misunderstood and people would stay in the induction phase far to long causing problems!Those who read the book know that once out of the induction phase one would increase healthy complex carbs back into the diet! Atkins even had a complex carb diet he called the millet diet for those who did not need to lose wieght but just wanted to get off junk food!
Today people are using the Atkins diet and concept to cure diabetis and other blood disoders!
The establishment hated Atkins and the American Wheat Council declared war on Atkins along with he American Dietitions Ass. and The American Diabetes Ass. who Atkins declared war on for not curing diabetes, which Atkins beleived was curable by diet alone! These groups put out much misinformation about the diet his motives and the countless felonious accounts of is death, which I see is still circulating through out the net.
Yes one will find much info discreting these diets and much misinformation to scare people away from these diets ,but one can find much info on the net that will discredit much of what alternative health has to offer.
However there is much info on the net about these diets and the many offsprings of these diets like Dr. Mercola and Price/Pottenger who have had much success and much acclaim !
These diets ability to heal and the many testimonials of success in curing epileptic siezures and diabetes should be considered and an open minded unbiased eye can give those in need an option that may be helpful in thier struggle to return to good health!
http://www.mercola.com/article/carbohydrates/scientific_evidence_low_grains.htm
http://www.medicalnewstoday.com/articles/6145.php
http://www.ppnf.org/catalog/ppnf/Articles/FatControversy.htm
- Re: Ketogenic Diet Prevents Seizures... Dquixote1217
17 y
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This is a reply to # 1,051,147Perhaps it is worth noting that, after negative studies and criticisms mounted, the original Atkins diet was belatedly modified and the revised Atkins diet addressed some of the issues raised in those studies and criticisms.
Also worth noting is that Mercola, whom I refer to often but do not always agree with, also stresses adequate healthy carbs.
As I posted earlier, in the interest of educating, readers are encouraged to do their own research and consider both the pros and cons and then make their own informed opinion. A Google search of "Atkins diet dangers" turns up a great number of links. One of which is from an Atkins site itself:
http://www.dratkinsdietplan.info/learn/atkins-diet-dangers.html
Atkins diet is completely opposed to anything else used for years before by traditional nutritionists and medical care experts. It has been scrutinized lately and some questions and concerns arised. Scientific data to strongly and entirely support medical concerns are still missing. Nevertheless, some incomplete or small studies which have been conducted until now can't be ruled out. Regarding lifestyle, atkins diet dangers are coming from four major directions:
Cardiovascular Risk Factors
First of all, physicians from the American Heart Association are worried because a high-animal protein and high-fat diet is damaging the heart condition and blood vessels' health (blood flow and blood clots especially). Emphasizing foods like meat, eggs, saturated fats and eliminating fruits and starchy vegetables, Atkins diet restricts, in fact, those foods rich in essential nutrients. The low fiber intake is also blamed by the American Heart Association. In their opinion, an eating regimen so rich in meat and fatty foods is highly favoring coronary heart diseases and even strokes. In 's opinion, many people are already eating too much high-protein and high-fat foods than they really need daily.'s opinion, many people are already eating too much high-protein and high-fat foods than they really need daily.
Kidney Stones
Regarding kidney stones, specialists quoted by “American Journal of Kidney Diseases” are worried because high-protein diets lead to a very high acidity in the human body (as much as 90%). The calcium level rises abnormally, too. These are responsible for increasingthe level of a compound called oxalate in the urinary excretion. This compound has the ability to combine itself with other present substances and calcium and give birth to kidney stones. This has been revealed by a small six-week study on ten healthy adults.
Osteoporosis
The same small study has shown that the same high levels of calcium in the volunteers' urine lets out a decreased absorption of calcium (saw as the bone-building material). Eventually, this causes osteoporosis.
Constipation
Constipation has already been admitted by dr. Atkins himself as an adverse effect of his diet, in the Induction phase (which is rather depriving the dieter of fibers). On a long-term basis, constipation might become chronic. Its appearance is harmful for two reasons:
- a bowel deficiency is the cause of dangerous toxicity in the human body
- its presence might push someone to become addictive to laxative medication
The nutritional care community is also suspicious regarding: nutritional adecquacy, dietary compliance and quality of life. Until now there are two charges related to “Atkins bad diet”: a 41-year-old male and a 16-year-old girl died while on Atkins diet. It is worth mentioning that the American National Institute of Health is now conducting a large 3 year-study on low-carb dieting, including Atkins diet.
I cannot help but point to what what Atkins autopsy revealed, which among many health problems was the fact that he had previously suffered a heart attack, as well as the statement by the Mayor of New York City that Atkins was "fat".
I think that in general, the healthiest diet is one which incorporates much of the same kinds of foods that our ancestors evolved, or adapted if you will, to eat over tens of thousands of years, and yes that did include meat whenever the hunts were successful, but also included lots of raw vegetables, fruit, nuts, tubors, and some grain. None of those foods were subject to the contaminants present today in our air, soil and water as well as the nutrient depleted soils present today. Nor did they have the nutrition processed out and harmful additives processed in for longer shelf life, taste, color and texture.
And so, in a nutshell, my personal recommendations are a diet close to that of our ancestors, a day each week of healthy fasting, meals made of smaller portions with healthy snakcs between meals, thoroughly chewing each bite, and a glass of pure water before and during each meal and snack.
Such a diet, along with healthy lifestyle, fresh air and sunhine, elimination of stress and adequate supplementation to be sure one gets sufficient amounts of the essential vitamins, minerals and other nutrients, including plant derived trace minerals, is the way to go for most people in order to achieve and maintain optimum weight and health, in my humble opinion.
DQ
- Re: Ketogenic Diet Prevents Seizures... #89280
17 y
4,183
MoreThis is a reply to # 1,051,172Well Tony like I said there is much propaganda and much misinformation out there and you use it pretty well. The objective to my posts is to offer unbiased information with substantial success despite the negative information put out by establishment enemies of Atkins so that people can make up thier own minds.
My original post was to offer this information as an option that others have used successfully with much testimonial available and also with many studies that disagree with these questionable sources of the studies you offer.
I am only offering information that may help someone suffering from a terrible malady that has been treated successfully. I am not trying to discredit or diminish the value of the other options layed on the table. I am not trying to persuade other to over look or ignore any potential helpful protocol.
If you will read my post above the testimonial of one child going from 50 seizures a day to none is worth repeating and the fact that the ketogenic diet was responsible for this is worthy of note , plus you will notice that this child eventually was able to revise her diet to one that included more complex carbohydrates.
As I said before this diet is not for everyone and if one where to read the books would know that this diet needs to be adjusted in the long term. Too many people are under the assumption that one is to eat nothing but fat for the rest of their lives a myth perpetrated by the establishment and passed down by the unaware.
http://dir.salon.com/story/news/wire/2002/11/18/atkins/index.html
- Re: Ketogenic Diet Prevents Seizures... Dquixote1217
17 y
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This is a reply to # 1,051,188I use misinformation well? Pot, kettle - how do you do!
You know, this discussion was going along fairly nicely til you just could not help but make a slur here.
If you or anyone else truly thinks I use misinformation and propaganda, by all means do the Google search and look at the page after page of links and where they come from both within and without mainstream medicine and decide if I am using misinformation.
Again, what I have said is that I feel that your original post had good information as regards a ketotonic diet so long as it was not a strict Atkins diet, and I believe that the preponderance of evidence as well as opinion backs me up.
Here without further ado, is what the Google search I suggested returns, unaltered, for the first two pages.
Google search for "Atkins diet dangers"
587,000 hits for Atkins diet dangers
Atkins Diet Review
When it comes to long-term side effects, many health professionals are concerned that the Atkins diet may have serious dangers. While the high intake of fat ...
www.weightlossresources.co.uk/diet/atkins_diet/atkins.htm - 35k - Cached - Similar pages - Note this Atkins Facts - Dietitians Warn of Low-Carbo Diet Dangers
NEW YORK, Oct 19 (Reuters Health) - Individuals who stick to the high-fat, high-protein, low-carbohydrate diets such as the popular 'Atkins Diet' may risk ...
www.atkinsexposed.org/atkins/97/Dietitians_Warn_of_Low-Carbo_Diet_Dangers.htm - 44k - Cached - Similar pages - Note this Atkins Facts - Atkins 'Danger' Official
Atkins 'Danger' Official ... Atkins Nutritionals Inc, the company behind the diet, has denied the link. Last month, experts at the Government-funded Medical ...
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[ More results from www.atkinsexposed.org ]Low Carb Research & Studies - Dietitians warn of low-carbo diet ...
Low Carb Research & Studies - Dietitians warn of low-carbo diet dangers from the Atkins Diet & Low Carbohydrate Support: Atkins diet and low carbohydrate ...
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Atkins Diet: Hidden Dangers Justin Leonard, ISSA CFT, warns of hidden dangers you may be putting yourself at risk for by going on Atkins. ...
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Long term and short term atkins diet danger. The other side of the weight loss story.
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Low Carb Diet Dangers, Health Risks. ... Dangers of Low Carb Diet Health Risks of Low Carb Diets · Diet Home - Weight Loss Articles - Weight Loss Help ...
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Dr. Amy Joy Lanou, director of the Physicians Committee for Responsible Medicine in America, was quick to point out health dangers of the Atkins diet. ...
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The first official warning about the dangers of the Atkins diet has been issued by the Government amid concern about the rising number of people opting for ...
observer.guardian.co.uk/uk_news/story/0,,1046594,00.html - 46k - Cached - Similar pages - Note this What to do When the Atkins Diet Fails You ... and Why it Usually ...
Many people have asked, and now I tell you, why the Atkins Diet fails in most people ... testimonials that can attest to the potential dangers of sucralose. ...
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For example,Dr. Amy Joy Lanou, director of the Physicians Committee for Responsible Medicine in America, commented on the health dangers of the Atkins diet: ...
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Atkins Diet Alert, surgeons. Physicians Committee for Responsible Medicine, support us ... PCRM has been speaking out about the dangers of high-protein, ...
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Lancet Study finds health concerns with Atkins and low carb diets.
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The Dangers of High-Protein, Low-Carbohydrate Diets for People With Diabetes ... For example, the Atkins diet and Protein Power provide about 20% to 25% of ...
www.hopkinshospital.org/health_info/Diabetes/Reading/highprotein.html - 30k - Cached - Similar pages - Note this Newswise Medical News | Doctors Reveal Dangers of Atkins Diet
Doctors reveal dangers of Atkins diet in national advertising campaign: recent studies link meat-heavy diets to kidney damage, osteoporosis and colon cancer ...
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diet.lovetoknow.com/ - 43k -Cached - Similar pages - Note this Disease Proof: Nutritional Wisdom: Dangers of the Atkins Diet
In it Dr. Fuhrman talks about how dangerous an Atkins-type diet can be for children and others. In fact, it can have deadly consequences. Take a look: ...
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That's why I literally wrote the book on the dangers of the Atkins Diet: Low-Carb Diet Warning, which you can read free of charge. The answer to all this, ...
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The dieters slim fast and the weight loss is spectacular. But this performance shouldn't get into trouble the health. Atkins diet dangers have been argued ...
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The pounds may fall off in the first few months but the Atkins diet does not help people lose weight in the long term and it may be dangerous, according to ...
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Check out Is the Atkins' Diet Dangerous? - Submitted by Richard Morris at Associated Content.
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Low Carb Research & Studies - Negative Opinions from the Atkins Diet & Low Carbohydrate Support: ... Dietitians warn of low-carbo diet dangers NEW YORK, ...
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Udo Erasmus press releases, media communications, news on Products, Research, Health-Related Bulletins, information you and your family should know about ...
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Dangers of Atkins Sometimes I wonder if people are using the Atkins diet as an excuse to continue eating a heavy meat diet high in saturated fat. ...
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www.prevention.com/.../weight.loss/strategies.for.success/diet.sabotage - 91k - Cached - Similar pages - Note this And it goes on like that for page after page. I get the feeling that you are just one of those who does not like to have the least bit of disagreement with what you post. Maybe I'm wrong.
At any rate, feel free to have the last word as you seem determined to do.
Besides the fact that this is not a debate forum and I have stated my objections and concerns clearly, I have no further desire or intention to debate someone who has to resort to accusing their opponent of misinformation.
Cheers,
DQ (or Tony)
- Re: Ketogenic Diet Prevents Seizures... #89280
17 y
4,031
This is a reply to # 1,051,329"I get the feeling that you are just one of those who does not like to have the least bit of disagreement with what you post. Maybe I'm wrong.
At any rate, feel free to have the last word as you seem determined to do."
Funny Tony I get the same exact impression form you. I had already stood down in your forum and only made what I felt was an informative post on this forum only to be challenged once again by you.
Like I said and I repeat I am not the one trying to censor potentially helpful information, nor am I splattering this string with volumes of questionable misinformation put out by questionable sources with questionable motives.
The testimony offered stands far above the ubiquitis charges against Atkins.
If my child where afflicted with this debilitating disease I would be more then willing to hear any information that has offered others relief from thier illness.
Seems you have more at stake her then just helping others and you seem to see this as a personal affront apon your self important reputation, which was never my intention!
Perhaps you can go back to your forum and throw yourself a few more of the those multitudes of kudos you have granted yourself in the past, maybe a few more of those little red Rs that flower most of your past post will ease you concerns.
- Re: Ketogenic Diet Prevents Seizures... Dquixote1217
17 y
4,435
This is a reply to # 1,051,417
For your information, I do not usually award myself ratings - that comes from the co-mod, and I often have lowered them when I thought they were too high, and never once have raised them. It appears that this discussion has deteriorated into false accusations, innuendo and snide snippets in your last couple of posts.
Even in your so-called "stand down post" in my forum, you just could not help but take a parting shot with this phrase:
"if I had a child suffering from epilepsy I would not allow my personal biases to distract me from fully investigating any and all treatments that show some promise or hope."
which implies that I would let personal bias keep me from giving my forum members the very best possible information, something which I find personally insulting and which is, imho, a breech of etiquette for a personal forum.
As I pointed out in response to your sideways accusation I am not allowing my personal bias but rather my studied opinion based on the information I have researched and the opinions of others I respect who are far more knowledgeable than you or I.
As I also pointed out, it so happens that I have conducted quite a bit of research into just about every major diet out there in preparation for my own upcoming diet book.
In no way have I stated that I am opposed to a ketogenic diet, or even that I doubt that it could be beneficial, however it was you who specifically mentioned the Atkins diet, which I do oppose, and you who proceeded to "debate" the merits of my information and/or perceived bias.
However, I will say that although the ketogenic diet has had unarguable success in treating epilespsy, it appears fraught with dangers and it would seem incumbent to let parents know that so that, should they choose the ketogenic approach, they will know the importance of close monitoring. The following link goes to a study that appears to be anything but personal bias and anyone who has a child with epilepsy and is considering the ketogenic diet should take a look:
Dr. Atkins pioneered studies into the benefits of the ketogenic diet and these later became the basis for the famous Atkins fad diet which came to be marketed as a diet where you could basically eat all the animal fats, other fats and even junk food you wanted so long as you elminated carbohydrates.
Initially a great many people, including mainstream medicine, jumped aboard the bandwagon of such an appealing diet. However, as time went by reality sunk in and an increasing number of studies began to indicate long term damage risks associated with a diet that restricts all carbohdrates.
The simple fact is, some carbohydrates are essential for good health. So long as that is kept in mind, the ketogenic diet approach could be a good one.
I think that the question that is begging to be answered here is why you are unable to agree to agree on the ketonic diet in general, and agree to disagree on Atkins, instead of feeling compelled to mount a staunch defense of Atkins that flies in the face of the preponderance of evidence, as well as making this a personal issue.
If your reason for such a stout defense is not that someone disagreed with a very controversial version of the ketotonic diet and you could brook no disagreements, then it would be informative to hear just what your reasoning is.
Nevertheless, we agree that your original post here contained good information, whether or not you like to agree or not.
By the way, if I am the one who has such an issue with being contradicted and feel that I must preserve my almighty self-importance (you just have to keep making it personal don't you?), then why do you suppose that I did not merely delete your posts and restrict you from posting further?
I work very long hours every day, mostly trying to help other people, and I make a mere pittance for doing so. And yet I gladly do it for the rewards of easing suffering and preventing death. I know what is in my heart, as do those who know me best. I am trying to figure out what is in yours.
Perhaps, when all is said and done, both of our hearts are in the right place and this just boils down to a clash of strong willed individuals who defend strongly what they believe and became overheated in the process?
And just maybe we can at least agree on that, agree to disagree on the rest. let the feathers settle back down to earth and dispense with the war of words and wills.
Surely, we have both stated our case and the need to re-state it again and again is long past.
DQ/Tony
- Re: Ketogenic Diet Prevents Seizures... LuellaMay
17 y
4,412
MoreThis is a reply to # 1,051,417
First of all, let me say that Tony does not deserve the remarks you made. For starters, I am the one that gives him the kudos. Many times he lessens them, as he feels they are a bit too much.
Secondly, Tony has done hours and hours and years and years of research on various natural health alternatives and he does know what he is talking about. He has a love for people and gets no pay for the hours of research and work that he does. He has a passion for not leading people astray and gives information and advice that will help people. When he sees a discrepancy, yes, he will jump in. Regardless, he always let's the person make up their own minds. Tony would never insist on a certain protocol out of sheer pride. That is not what he is about.
Luella
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