Intensive Therapy Means You Will Die Sooner
with Good Looking Numbers 

I am outraged that no serious action is being taken by medical doctors to stop the conscious killing of patients by the pharmaceutical companies.  Responsible physicians need to stand up—we swore an oath to protect our patients—to keep their welfare as our highest priority—not to safeguard the earnings of any industry. Research over the past four decades has consistently shown that intensive drug treatment will lower risk factors, such as cholesterol, blood sugar, and blood pressure; but will also cause patients to die sooner, albeit, with better looking numbers. So far, any changes in medical practices resulting from all this bad news have been imperceptible.  In fact, most of my colleagues, without taking a single dime, readily come to the defense of the drugs they prescribe, and their manufacturers—the others take a bribe.

In general, people who have elevations of cholesterol, blood sugar, and blood pressure, known as risk factors, have a greater chance of having heart attacks and strokes in the future. These elevated numbers are the signs of disease, not actual disease. During my forty years in the profession (I started medical school in 1968), I have never seen a patient die of high cholesterol, high blood sugar, and/or high blood pressure.  These people die from rotten arteries, manifesting as strokes and heart attacks. Drugs won’t heal the sick arteries. The reason pharmaceutical companies sell drugs that treat the signs of diseases is they can.  The reason they don’t sell drugs that cure the underlying diseases is they can’t.

To compound matters, medications cause “warning messages” to disappear, leading many people to a false sense of security. As a direct result, they fail to take appropriate actions to improve their diets and lifestyles—measures that would make real differences. During patient interviews (a history I take when people come to my 10-day, live-in program), I often notice that the “disease portion” of their data sheet is left blank, while their medication list is extensive.  I ask, “Why have you left this section about your diseases blank, when you are taking three medications for high blood pressure, two for diabetes, and a statin?”  Their answer: “I don’t have these problems anymore, since I started taking these drugs.” They believe they have been cured because the “warning messages” are gone.  But this deduction is contrary to common sense and the results of extensive scientific research. 

Aggressive Treatment of Diabetes Kills

Diabetic medications are approved for market based upon their ability to lower blood sugar levels, not based on any improvements in the quality or quantity of the patients’ lives. A popular diabetic medication, Avandia (rosiglitazone), given at a dosage of 4 mg twice daily, on average, decreases hemoglobin A1c by 1.5 percentage points, reduces fasting plasma sugar by 76 mg/dL (4.22 mmol/L), and reduces insulin resistance by 25%.¹ Urinary protein excretion also decreases significantly.  Logically, these improved numbers should mean healthier patients, but they don’t.  On May 21, 2007 the New York Times reported, “…patients taking Avandia had 66 percent more heart attacks, 39 percent more strokes and 20 percent more deaths from cardiovascular-related problems.”^2,3 That same day the FDA issued a Safety Alert on Avandia.  Paradoxically, this study funded by Glaxo, was called “the DREAM study,” (an acronym for Results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication). In reality, the nightmare for patients continues as this toxic drug is still marketed aggressively to patients and their doctors.

On February 6, 2008 the National Heart, Lung, and Blood Institute (NHLBI), stopped the ACCORD study (Action to Control Cardiovascular Risk in Diabetes) when results showed that intensive treatment of diabetics increases the risk of dying compared to those patients treated less aggressively.⁴  Patients in the intensive group were sometimes taking four shots of insulin and three pills daily, and checking their blood-sugar levels four times a day. The goal of intensive treatment was to make the patients’ blood sugar numbers as close to “normal” as possible, as measured by a hemoglobin A1c. (This test reflects long-term sugar control).  Those with the “better numbers” died more often.

The DREAM and ACCORD studies are not the first time aggressive treatments with insulin and diabetic pills have been reported to harm and kill people. Since 1972, the Physicians Desk Reference (PDR)’s descriptions of every diabetic pill have included two paragraphs in heavy black print that begin with: “Special Warning on Increased Risk of Cardiovascular Mortality.” Even more scandalous, three major studies published between 1996 and 2000 have shown more weight gain, higher cholesterol, triglycerides, and blood pressure; and more heart disease, stroke, and/or death with “aggressive” treatment compared to less treatment.^5-7

Aggressive Treatment of Cholesterol Kills 

Worldwide, the number one prescribed medications are statins for lowering cholesterol.  Doctors have been so seduced by provocatively dressed, attractive, young female “drug reps,” and the “science,” that many have come to believe that, “these drugs are of such great public benefit that they should be put into the drinking water for everyone to consume.” In truth, their benefits have been established only for people with very high risks, such as patients with a history of previous heart surgery, heart attacks, and/or strokes.⁸ Hardly mentioned are the serious side effects, including death, and the fact that these drugs are approved for market based upon their ability to lower cholesterol levels, not based on any improvements in the quality or quantity of the patients’ lives.

Vytorin, a combination of Zocor (a statin which blocks cholesterol synthesis) and Zetia (which blocks intestinal absorption of cholesterol), rocketed to the third best-selling cholesterol-lowering medication soon after its introduction in 2004.  In 2007, Vytorin was a $4 billion-a-year treatment, but sales should be slightly off for 2008. After withholding the results from the public for nearly two years, on January 14, 2008, the company Merck/Schering-Plough Pharmaceuticals, announced, under pressure from the US Congress, that even though patients taking Vytorin dramatically lowered their cholesterol levels, they achieved no improvement in survival, compared to Zocor alone; and doubled the thickness of their arteries (intimal-media thickness).⁹ This thickening is associated with an increased risk of stroke and heart attacks.  Not coincidentally, Zocor, ran out of its patent protection in June of 2006. For damage control, one week after this report on Vytorin, Merck/Schering-Plough Pharmaceuticals ran full two-page ads in newspapers worldwide.

Aggressive Treatment of Hypertension Kills

Anti-hypertension drugs are approved for market based upon their ability to lower blood pressure levels, not based on any improvements in the quality or quantity of the patients’ lives. Over the past 22 years, multiple studies have shown that aggressive treatment of hypertension with a goal of making the numbers look normal (110/70 mmHg or less), increases the patient’s risk of heart attack, stroke, brain damage, and/or death.^10,11 The phenomenon is known as the “J-shaped curve of mortality.”  Meaning: lowering the pressure to a certain point is beneficial (that is the first part of the “J” shape), but beyond that point of reduction, the patient is harmed (the second part of the “J”). This harm is found with both systolic (top number) and diastolic (bottom number) pressure changes.  Based on solid research, diastolic blood pressure should not be reduced below 85 mmHg by medications.¹²

In June of 2006 an extensive review of the data on 22,576 patients with heart disease and hypertension was published. When treated with medications, the incidence of heart attacks, death, and/or stroke was three times higher for patients with a diastolic blood pressure of 60 mmHg compared to a pressure of 80 to 90 mmHg.¹⁰ Another study of the elderly found a 14% increase in strokes in those whose diastolic pressure was lowered by only 5 mmHg with medications (starting average of 177/77 mmHg).¹³  Furthermore, the brain function in the elderly is impaired by intensive treatment of blood pressure with medication.¹⁴  This loss of intelligence may be permanent in some cases.

Why Does Intensive Therapy Kill? 

You might expect the results of pharmaceutical treatments for chronic disease to be neutral, because the therapies are directed at risk factors rather than the underlying illnesses.  Not so—the more intense the treatments, the worse the outcomes. Medications have serious, sometimes fatal, side effects—but this is only a small part of the answer.  

The most important reason intensive therapy kills is that drug treatments, which focus on the signs and symptoms of disease, are counterproductive to the body’s efforts to stay alive under adverse conditions. We are designed to live optimally under conditions of clean air, water, and food (a starch-based diet).  If these ideal surroundings are not met then adaptations must be made to survive.  For example, when people smoke cigarettes they cough and produce mucous in an effort to remove the toxic smoke from their lungs.  These adjustments also serve as signs of the on-going lung injury. If cough-suppressing medication, for example, codeine syrup, were used intensive to completely suppress the cough, then more of the toxic chemicals from the smoke would be retained—hurrying the person’s demise. 

In addition to serving as signs of disease, elevation of the blood pressure and blood sugar (and maybe cholesterol) also serve as part of the corrective adaptations that the body makes in response to the burdens caused by the unhealthy Western diet. In the case of hypertension, the blood pressure increases in order to improve circulation. The Western diet reduces the flow of blood to the tissues by creating blockages (atherosclerosis), spasms of the arteries, and the clumping of blood cells.  The net effect is an increase in (peripheral) resistance to the flow of blood. To compensate, the blood pressure rises in order to restore adequate perfusion to the tissues.  A rise in blood pressure is the correct response for the body to make under these circumstances.  

The pharmacological, medical answer to elevated blood pressure is to poison various parts of the cardiovascular system: beta blockers are given to weaken the heart muscle, calcium channel blockers prevent normal contraction of the arteries, anti-angiotensin drugs block the actions of adrenal hormones, and diuretics inhibit the kidneys’ ability to conserve water and minerals. Rather than improving the circulation, these drugs cause the opposite: a further decline in perfusion pressure—counteracting the body’s efforts to deliver adequate oxygen and nutrients to the tissues.^15,16  The result, as would be expected from worse circulation, is more damage, seen as an increase in the risk of strokes and heart attacks, and loss of brain function (dementia).

Resistance to the actions of insulin develops in response to the burdens of the Western diet. This adaptation is made in part to stem excessive weight (fat) gain. One of the primary jobs of insulin is to store fat in the fat cells.  After the accumulation of the first 30 pounds of fat, the body seems to say “that’s enough,” and puts the brakes on by reducing the effectiveness of insulin—in other words, insulin resistance develops. With weaker insulin activity, the blood sugar rises. Injections of insulin partially override this natural resistance causing weight gain to accelerate.  Medications, like Byetta injections and sulfonylurea pills, cause the pancreas to release more insulin with effects similar to insulin shots. Artificially lowering blood sugar with these drugs also prevents excess calories (sugar) from being eliminated through the kidneys (glucosuria), further hindering the body’s attempts to make overdue corrections by losing its excess fat. The net result of all this intensive therapy is accelerated accumulation of body fat, which means a sicker patient at more risk of death and complications. (In addition to causing obesity, intensive therapy results in many other biochemical changes that are counterproductive to survival.)

Lowering cholesterol with drugs, like statins, does little or nothing to heal the sick arteries. To make matters worse, Zetia (ezetimibe), an ingredient in Vytorin, appears to further damage a patient’s arteries. Zetia works by blocking the absorption of cholesterol (an animal-synthesized sterol) by the intestines.  This drug at the same time blocks the absorption of plant-derived sterols in every person taking Zetia.¹⁷ Unlike cholesterol, plant sterols cannot be synthesized within the body; therefore, they must be obtained from a diet of starches, vegetables, and fruits.  Plant sterols are essential for our health, and more specifically, they are vital ingredients for healthy arteries.  These sterols lower total and LDL (bad) cholesterol by a variety of mechanisms, and reduce oxidative stresses and inflammation, which lead to atherosclerosis.¹⁸  

Doctors, It Is Time to Prescribe the Miracle Drug: Food 

The facts are indisputable: The intensive pharmaceutical treatment of signs of chronic diseases is a failure—causing great mental, emotional, physical, and financial harm to patients. Since doctors are the gatekeepers of treatment, they have the opportunity and duty to change medical care.  We must stop prescribing treatments that don’t work. 

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