During men's stage of life, elevated levels of testosterone is reached at the time of puberty and reached the maximum level in early adulthood. This is followed by a stabilize decline in testosterone levels with age. In a studies of men with 30 or 40 years and older, in general free testosterone levels decline when age increases. A drastic decrease in free compared concentrations of bioavailable and total testosterone. Low testosterone levels can be the consequence of many factors.
It is important that cases of total and free testosterone, are greater than longitudinal studies consistently in cross-sectional analysis. In one of the study conducted by Massachusetts Male Aging Study of 1709 men aged 40-70 years, it revealed that testosterone declined total cross section of 0.8% annually of age, with a further 2% reduction in bioavailable free testosterone. The numbers is comparable in reductions the longitudinal old participating in the 1.6 and 2.3% per year, respectively.
In men aged 65 years or 70 years, changes in total testosterone was eclipsed by the most significant decreases testosterone levels . The notice that has been fixed in a cross-cutting analysis of 3638 men aged 70 and over testosterone levels. Overall levels of free testosterone decreased with age in a study describing total testosterone comparable levels in groups of men between the ages of 19 compare to 76 years old. At constant total testosterone, SHBG increased by providing sites for testosterone more binding expected to reduce the percentage of free testosterone and SHBG increased increasing age. Thus, while total testosterone and SHBG related in men older age continues comparatively related increase in SHBG could modulate free testosterone levels in an environment where total testosterone. It is important to note, the different mechanisms affecting are likely to reduce levels of testosterone in aging and older men. Having a low testosterone level in aging men can cause bit problems in men's live.
Lower levels of testosterone may be the effect from the reduction of testicular response to LH with aging, combined with the lack of hypothalamic-pituitary-offset low total and free testosterone. The pivotal question is whether the changes in SHBG passing around androgens and physiology of normal aging, or the reduced availability of androgens cause of disease in the elderly men.
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