Treatment of TMAU with Fecal Transplant

Hi everyone, I thought you might be interested with a little interview I did with a Greg Taylor from Taymount clinic in the UK. He is having success with treating secondary TMAU with fecal microbiota transplants (FMT). I think this method holds great potential in rebalancing our microflora both quickly and for longer lasting benefits. I'm preparing to do some home FMT treatment myself and will document the process on my blog in a month or two.




We recently carried out a treatment on a patient with Trimethylaminuria – TMAU. She had the Type 2 (non-genetic variant). You will need to Google TMAU to see the full description. The way that her TMAU expressed itself was not as the usual “fish smell syndrome” but more as a combination urine/fecal smell. Socially she was scarred as one might imagine. After 10 implants she felt confidant enough to leave her hotel room and visit coffee houses, where she was astounded to find that she completely blended in, not eliciting the usual wrinkled noses and derogeratory comments. This prompted her to take the train to London and to use the Underground where she had many opportunities to be in extreme close proximity to others. She reported back that she blended in completely and felt that her odour had totally gone. We are now arranging to start formal trials of the treatment of Type 2 TMAU with FMT.

This patient had a 10 day treatment. We need to back this up with formal clinical analysis, but initially we feel that there is a possibility that not only did the patient’s liver not produce the critical enzyme FMO3, but neither did her previous dysbiotic Microbiome. It could be that the new diverse bacteria in the FMT implants contained species capable of producing FMO3 (bacteria species produce literally hundreds of times more enzymes than humans can). If the Trimethylamine is being broken down by bacteria, there is no way of knowing at this stage, how long the effect will last until we isolate the specie(s) involved. It could be month or years, it is just too early to say. I have been sharing the results with Tom Borody, who is keen for me to start a formal trial procedure. I have started talks with a clinical analyst to this end.
Talk soon
Jordan
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