Don't have much hope for an answer, but were you, by chance, on nitazoxanide for the Hep C? I have schistosomes and fasciola hepatica, so my doctor is trying to get me on that. I also get those creeping sensations when I smoke, but I get the same sensations elsewhere. I do not have hep C and all my liver enzymes are textbook perfect, but I do have liver pains and occasional swelling. The increased high for me is caused by berberine, though, not blocked or damaged pathways. Testing confirmed that.