It is fine!!! I have taken it three times and my family has taken it at least three times. You want to make sure your tummy is settled the day you take it. Don't take it minutes after an enema, or right after a liver cleans. I took the Q12 too close to an enema once and lost most of it due to diarrhea. The next time I used Q10, I made sure that my tummy was settled and that I had not done something right before to cause my flushing system to be open and active.