After years of mucosal damage, involving discovery and battles with dysbiosis, bacteria and metals, a very intuitive practitioner clued me on a basic component missing in my genetic make up: Trypsin, which is one third of one's enzyme cascade. Apparently, as I suspected, a non secretor doesn't produce a normal amount. Therefore, toxins which aren't sufficiently broken down accumulate, leading to chaos eventually. Although it will take a long time to eliminate, I am actually detoxing and can feel it. I take enzymes twice a day that have trypsin. This could be THE reason non secretors have low iga, then bacterial overgrowth, metals then excessive free radicals etc. It has always felt like I was using a spoon instead of a shovel to detox!