Functional Brain Imaging Alterations in Acne Patients Treated With Accutane

Functional Brain Imaging Alterations in Acne Patients Treated With Accutane

Functional_Brain_Imaging_Alterations_in_Acne_Patients_Treated_With_Accutane.pdf 254.1 KB Functional_Brain_Imaging_Alterations_in_Acne_Patients_Treated_With_Acc

PDF File   254.1 KB

Uploaded by   Anonymous     Report Spam

Am J Psychiatry 162:5, May 2005
Functional Brain Imaging Alterations
in Acne Patients Treated With Isotretinoin
J. Douglas Bremner, M.D.
Negar Fani, M.S.
Ali Ashraf, M.D.
John R. Votaw, Ph.D.
Marijn E. Brummer, Ph.D.
Thomas Cummins, M.D.
Viola Vaccarino, M.D., Ph.D.
Mark M. Goodman, Ph.D.
Lai Reed, M.B.A.
Sajid Siddiq, M.D.
Charles B. Nemeroff, M.D., Ph.D.
Although there have been
case reports suggesting a relationship be-
tween treatment with the acne medica-
tion isotretinoin and the development of
depression and suicide, this topic remains
controversial. In order for isotretinoin to
cause depression, it must have an effect
on the brain; however, the effects of
isotretinoin on brain functioning in acne
patients have not been established. The
purpose of this study was to assess the ef-
fects of isotretinoin on brain functioning
in acne patients.
Brain functioning in adults was
measured with [
positron emission tomography before and
after 4 months of treatment with isotreti-
noin (N=13) or an antibiotic (N=15).
Isotretinoin but not antibiotic
treatment was associated with decreased
brain metabolism in the orbitofrontal cor-
tex (–21% change versus 2% change for
antibiotic), a brain area known to medi-
ate symptoms of depression. There were
no differences in the severity of depres-
sive symptoms between the isotretinoin
and antibiotic treatment groups before or
after treatment.
This study suggests that
isotretinoin treatment is associated with
changes in brain functioning.
(Am J Psychiatry 2005; 162:983–991)
Back To Album
Copyright infringement? Contact the Webmaster and request removal of this file!
To embed this file into your forum/blog entry, highlight the URL, right-click and copy it, and then paste it into the body of your forum or your blog message, while in text mode (plain text editor).

If posting a message by using a HTML editor (FCK or MCE), you will have to use the appropriate buttons (Insert Image) from the editor toolbar. HTML editors have buttons for inserting hyperlinks, images and other HTML objects.

Functional Brain Imaging Alterations in Acne Patients Treated With Accutane

Uploaded by Anonymous
Click Here To Vote!Total Votes: 0       Hits:  1335
( 254.1 KB )

Donate to CureZone


Donate to CureZone

Contact Us - About - Sponsors - Stats

Link Exchange - Add URL - How To Exchange Links?

Terms of Service - Privacy Policy - Spam Policy - Disclaimer - Guidelines & Rules

CureZone Newsletter is distributed in partnership with

Copyright 2021

0.5000 sec from

New lower prices!
Hulda Clark Cleanses

Lugol’s Iodine Free S&H
J.Crow’s® Lugol’s Iodine Solution. Restore lost reserves.