Date:   9/9/2007 7:34:53 AM ( 17 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=960290

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'..a strong oxidizer like iodine(especially the I2), was using up the glutathione in the liver faster than it could be replaced and causing oxidative stress of the tissues.'


This has been discussed liberally, but perhaps it bears repeating.

If I2 is utilizing liver glutathione stores (which are needed for the liver to detox toxins en route thru the liver), perhaps providing the body with foods/supplements which boost glutathione stores would lessen the oxidative stress manifestations in the body. Precursors to glutathione would be best to use since ingesting glutathione itself is practically useless.


http://www.comparativeguide.com/reports/glutathione.html



Glutathione stores can be replenished via:

Supplementation

While dietary glutathione is efficiently absorbed in the gut, the same may not be the case for nutritional supplementation. Oral dosing appears to raise glutathione levels, albeit with great variability between subjects. In one study, oral supplementation raised glutathione levels from two to five-fold. In another study, absorption of a single dose of 3,000 mg was negligible. Such variations raise concern about the efficacy of supplementing with glutathione itself. As a tripeptide (protein fragment), glutathione would tend to be hydrolyzed (broken down) during the digestive process. This leads some researchers to conclude that oral supplementation with glutathione does not appear to be cost effective in light of other methods available.

Vitamin C Replenishes Glutathione

In contrast, daily supplementation with vitamin C appears sufficient to enhance and maintain good tissue glutathione levels, provided the necessary metabolic precursors for glutathione synthesis are also available. One double-blind study found that red blood cell glutathione levels increased nearly 50 percent when subjects were given 500 mg per day of ascorbic acid (vitamin C)

In patients with hereditary glutathione insufficiency, Jain and co-workers found vitamin C to be more effective and less costly in raising glutathione levels than N-acetyl cysteine, another well-known and effective glutathione booster. Vitamin C appears to boost glutathione levels by helping the body manufacture it.

When given orally, S-adenosyl methionine (SAM-e) is also effective in raising red blood cell and liver glutathione. Unfortunately, while sold in the United States, SAM-e is not yet commercially available in Canada.

Cysteine, the metabolic precursor that most severely limits the synthesis of glutathione, is another nutrient that has proven very effective in boosting glutathione levels. Unfortunately, at high doses cysteine has been found to auto-oxidize, raising questions about its safety as an oral supplement. N-acetyl cysteine (NAC), however, is another story.

N-Acetyl Cysteine

N-Acetyl Cysteine (NAC) is a cysteine precursor that appears to avoid the problems of auto-oxidation attributed to cysteine. In the cell, NAC converts easily to cysteine, which, in turn, converts to glutathione. NAC is well absorbed in the intestinal tract and has been found to significantly boost glutathione levels in deficient subjects. As well, NAC demonstrates strong antioxidant, anti-mutagenic and anti-carcinogenic properties. Doses of up to 600 mg per day have proven to be an effective and safe means of optimizing tissue glutathione levels. Interestingly, while both NAC and vitamin C are effective in boosting tissue glutathione insufficiency, one study demonstrated that vitamin C was both more effective and less expensive than NAC.

The use of NAC products has become increasingly popular as a means of optimizing tissue glutathione; however, caution against too much of a good thing is advised. There is evidence that, at high doses (exceeding 1-2 g/day), NAC can also act as a pro-oxidant and begin contributing to the level of oxidative stress.

- Milk Thistle

- R-lipoic acid

- Natural foods that boost glutathione levels asparagus is a leading source of glutathione. Foods like broccoli (2), avocado and spinach are also known to boost glutathione levels. Raw eggs, garlic and fresh unprocessed meats contain high levels of sulphur-containing amino acids and help to maintain optimal glutathione levels.

- Undenatured Whey Protein Isolate

- Tumeric

- Balloon Flower Root Changkil saponins (CKS) isolated from the roots of the Chinese herbal medicine, Platycodon grandiflorum A. DC (Campanulaceae), commonly called Balloon Flower Root or Jie Geng, have been found to increase intracellular glutathione (GSH) content and significantly reduce oxidative injury to liver cells, minimise cell death and lipid peroxidation.

- Selenium


 

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