Date:   9/7/2007 7:09:37 AM ( 17 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=958924

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There are some issues with titanium that are suspected and recently coming to light, such as fibrosis in the lungs. I also have run into a 600 day half life in the body. The half life bothers me.

I am sure you are aware that titanium is used in sunscreens and cosmetics... some dies used in cosmetics are metal based. The more recent use of nano particles in cosmetics is of great concern and opens a whole new door. Where no known issues have been shown conclusively with implants (at least from what I have read - does not include the glues - read on), nano particles are another story. Titanium is used in implants and surgical glues among other things.

"Kumazawa, et. al. in their study, "Effects of Titanium Ions and Particles on Neutrophil Function and Morphology" concluded that cytotoxicity (danger to the cell) was dependent on the particle size of titanium dioxide. The smaller the particle size, the more toxic it is (see Table 2)."

"We have seen, however, that if titanium dioxide particles used to act as a sunscreen are small enough, they can penetrate the cells, leading to photocatalysis within the cell, causing DNA damage after exposure to sunlight (Powell, et. al. 1996) The fear is that this could lead to cancer in the skin. Studies with subjects who applied sunscreens with micronized titanium dioxide daily for 2-4 weeks showed that the skin can absorb microfine particles. These particles were seen in the percutaneous layers of the skin under UV light."

This is from an article posted by an organic make up company...

http://www.theorganicmakeupcompany.com/CA/titaniumdioxide.asp

This one is from holisticdental.org

"Wang (1) has shown that titanium particles can cause the osteogenic differentiation of human bone marrow, stroma-derived mesenchymal stem cells, to be suppressed. It also causes decreased cellular viability, proliferation, and inhibition of the extra cellular matrix mineralization. Decreased cellular viability is caused by apoptosis, and an increase in the level of tumor suppressor proteins."

"Ferreira (4) looked at the short-term effects on the spleen after exposure to titanium. After 72 hours of exposure, the spleen showed alterations in morphology, and irregular features within the capsule and medulla. Namely the T4 and B cells. Alterations in the functioning of T and B cells will effect the functioning of the immune system."

"A case study reported by Munichor (7) found metallic particles inside an inguinal-pelvic mass adjacent to a total hip titanium replacement, and arthroplasty. The 72-year-old patient developed the right pelvic mass after the hip was replaced. A fine needle biopsy was performed, and the histopathology showed fibro connective tissue with chronic inflammation and marked lymph node sinus histiocytosis.

Coen (8) has stated that particular debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells. Wouldn't this also be true for titanium implants in the first molar region?

Watanabe (9) placed macrophages in both a fibrous environment of titanium oxide, and particulate environment. The fibrous TiO (2) macrophages exhibited an increase in LDH release, no apoptosis, but a significant change in cellular vacuolars, and cell surface damage. The conclusion of the study was that titanium oxide toxicity was dependent on the shape of the material."

"Wilke (11) also showed the increase in LDH as a sign of increased inflammation when human bone marrow cells were incubated with titanium. The production of osteolytic mediators is responsible for the aseptic loosening of hip prosthesis. This would also be true of dental implants located in areas of high masticatory forces.
In conclusion, titanium and its oxidizing by-products are not as inert and biocompatible as once believed. Advances in research technology are showing changes to immune reaction cells in the blood, and the lungs. These findings should be taken into consideration when deciding whether or not to remove an implant on a particular patient. The dentist should also take precautions for their own safety when removing an implant, or when adjusting a titanium partial with a high-speed drill."

http://www.holisticdental.org/titaniumtoxicity.html

It does seem that the bottom line with titanium, whether used in cosmetics, implants, or in other applications is particle size...

The references on both of these sites will give you some names to search on for more information.
 

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