Date:   6/1/2002 1:01:57 PM ( 22 y ago)
Hits:   3,852
URL:   https://www.curezone.org/forums/fm.asp?i=65923

Sorry, it's me again ...

Before you make a claim or suggestion, it helps researching a literature ...

Galsones can actually form in a few days, in a few months or in a few years. Every person is different.



Refernces:
From:
http://jeffline.tju.edu/CWIS/DEPT/GI/education/pdfs/gallstones.pdf
Pathogenesis of gallstones
Robert Coben, MD



Read this Excerpt:


2. Nucleation: The next step in cholesterol gallstone formation is nucleation of cholesterol into crystals, followed by agglomeration of crystals and growth of the microlith into macroscopic gallstones.


Nucleation promoters: Even when supersaturated with cholesterol, fresh bile from subjects without Gallstones rarely contains cholesterol crystals. The same bile, when incubated, forms crystals very slowly (up to 15 days). Bile of patients with cholesterol gallstones, on the other hand, usually does contain cholesterol crystals, and its nucleation time, when incubated, is much more rapid (mean of 2.9 days). Nucleation of cholesterol occurs far more rapidly from gallbladder bile of patients with cholesterol Gallstones than from hepatic bile in the same patients, even when hepatic bile samples are supersaturated with cholesterol. The addition of even small amounts of gallbladder bile to the hepatic bile samples causes rapid nucleation. These observations have led to
the isolation of proteins in the gallbladder that promote or retard the nucleation of cholesterol crystals. At least five proteins have been identified as putative nucleation promoters, in addition to gallbladder mucoprotein. High doses of aspirin reduce the
incidence of Gallstones in a prairie-dog model, perhaps by inhibiting the synthesis of a nucleation promoter. Success in other species has been variable.



Raed This whole article here:

http://jeffline.tju.edu/CWIS/DEPT/GI/education/pdfs/gallstones.pdf

Pathogenesis of gallstones
Robert Coben, MD


Educational Goals

By the end of this lecture you should be familiar with:

1. Pathogenesis of gallstones.
2. Clinical manifestations of gallstones.
3. Approach to the diagnosis of gallstones and their related morbidity.
4. Treatment modalities for gallstone disease.


 

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