Date:   7/1/2005 8:09:54 PM ( 19 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=619924

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Hi,
I'm new to this forum and I'm currently writing a book called "Misery Guts".

An article was published in the Lancet in June 2003 called "Is Candida albicans a trigger in the onset of coeliac disease?" by Nieuwenhuizen WF, Pieters RH, Knippels LM, Jansen MC, Koppelman SJ.

"Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans-hyphal wall protein (HWP1) - contains aminoacid sequences that are identical or highly homologous to known coeliac disease-related alpha-gliadin and gamma-gliadin T-cell epitopes. HWP1 is a transgultaminase substate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transgultaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as and adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.
 

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