Date:   12/31/2005 7:49:00 PM ( 19 y ago)
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Introduction: What are Glyconutrients or Essential Sugars?
The eight "essential"* sugars are: mannose, glucose, galactose, xylose, N-acetylglucosamine, N-acetylgalactosamine, fucose (not to be confused with fructose), and N-acetylneuraminic acid. They are very important for health. I will not spend time dwelling on all the benefits as others have already done this in ample detail. In addition to the essential sugars, most of the ingredients in this recipe provide other health promoting properties as well. The aim here is to provide a simple and inexpensive way of getting glyconutrients. So let us now look at these eight sugars and see where we can get them from.

1. Mannose.
Mannose may be the single most important of the eight sugars for us to get plenty of. One of the main sources is aloe vera, which contains acemannan. Acemannan is a mannose polysaccharide (i.e. a chain of mannose molecules). From what I’ve studied, most commercial supplements of aloe only have very small amounts of acemannan in them so the best way is to grow the aloe vera oneself. It is a very handy herb to have in the garden or green house (e.g. good for minor burns and some skin ailments) and it is easy to cultivate. Consult a gardening book, but apparently it needs a sunny spot that’s not too moist. I may want to enjoy using plenty of it, so ideally would like to invest in about ten plants. While I am waiting to buy and establish my own aloe plants I can use the glyconutrient powder which does have mannose in as well. This is from the kelp, the shiitake and the ground fenugreek. I have actually recently decided to just take the glyconutrient powder (as detailed below) because I find it easier. Fenugreek contains plenty of galactomamman, a polysaccharide of mannose and galactose (other sources of galactomamman are carob gum and guar gum). Ground fenugreek should be readily available from a good health food store or supermarket, or I can buy the seeds and grind them myself. I prefer organic fenugreek. Shiitake mushrooms have in them a compound called KS-2 which contains mannose bound to an amino acid. We will say more about shiitake (and kelp) later. Using fenugreek, kelp and shiitake should not be very expensive. Aloe vera plants may be expensive to start with, but a friend may have a "jungle" of the plants and be able to give some.

2. Glucose.
Regarding the powder, glucose is found in kelp. But we don't really need to supplement glucose as it’s so abundant in our diets anyway. For the "jam" recipe the prime source is 100% pure grape juice, preferably dark organic (but I don’t worry if it’s not feasible). The grape juice will help, along with the next item, to make the aloe vera taste yummy instead of yuck. This juice is relatively cheap and if I have a juicer I can make my own.

3. Galactose.
Galactose is present in the fenugreek of the powder and also in a lot of foods that we normally eat. For the "jam" recipe the prime source is 100% pure apple juice, preferably organic. This juice will help, along with the previous item, to make the aloe vera taste yummy. Both apple and grape juice have health properties of their own. Again this juice is relatively cheap and those with juicers can make their own. Some analyses don’t report galactose as being in Apple juice. This is because the galactose is in the pectin fibre which is present in varying amounts in juice.

4. Xylose.
Xylose is present in the kelp used in the powder. Ground psyllium seeds are high in a xylose polysaccharide. They are cheap and easily obtained from a chemist or health food store. Psyllium is used in the "jam".

5 and 6. N-acetylglucosamine and N-acetyl-galactosamine.
Vegetable sources:
For those not wishing to consume medicinal animal products orally it is nice to know that Shiitake Mushroom contains N-acetylglucosamine (as a constituent of chitin). I can purchase fresh and/or dried Shiitake Mushrooms from many supermarkets and food stores. I buy dried whole shiitake mushrooms and powder them by using my liquidiser. Or I can buy a tablet with shiitake in. Shiitake Mushrooms do not contain N-acetyl-galactosamine. I thought that mistletoe contained N-acetyl-galactosamine but it appears that it does not. Instead it seems to contain a lectin that is specific for the N-acetyl-galactosamine receptor site. Also there are some toxicity issues with mistletoe. N-acetyl-galactosamine is contained in dextran sulphate, which is present in a red algae called Dumontiaceae. But this product is only available from Japan as far as I know (Update: but appears to also be available from http://www.herpes.com/qc/purchaseform_qc.shtml. Also received this message from someone: "A source for Dumontiaceae: http://www.dynamune.com/#RMA This is the only place I found a bulk powder (250g for $40)".

Animal Sources:
Bovine cartilage and shark cartilage both have an abundance of these two essential sugars. These are both relatively cheap and available from a chemist or health food stores in capsules or loose powder. I prefer the bovine cartilage because it is predominantly the chondroitin 4-Sulfate form of chondroitin which is apparently slightly better (shark is predominantly chondroitin 6-Sulfate). I am not especially concerned about prions and [BSE] from a bovine source because I can check where the cows come from and cartilage is not one of the tissues especially at risk for prion contamination. Actually, from what I’ve read, chondroitin is a substance that can be used to help treat prion disease as it interferes with the prions doing their dirty work in the nervous tissue. I am more concerned about the possibility of heavy metal contamination in shark cartilage, though I have not read any major problems regarding this. Those not wishing to consume animal products orally could use an Arthritis cream containing chondroitin sulphate. The best cream I know of is Arthro-Aid Direct, which should be rubbed on the tummy at the time the glyconutrient powder is consumed.

7. Fucose.
Kelp seaweed is rich in fucoidan, a polysaccharide containing plenty of fucose. Fucoidin is a complicated molecule that also contains xylose, mannose, galactose, and glucose. If anyone has an overactive thyroid they should not take this or other sea weeds without medical advice and monitoring. An alternative is beer yeast, which, according to my research, also contains plenty of fucose. Kelp has many health benefits and can be bought cheaply as a powder. It does not taste good to me!
Compare Seaweed.

8. N-acetylneuraminic acid (otherwise known as sialic acid)
is found in whey protein isolate. Whey protein isolate also contains lots of other goodies. If allergic to diary (though I am told some that are allergic to diary can take the isolate) an alternative is egg, which may be best raw. I need to make sure it is an organic egg from a healthy chicken. I need to make sure I buy whey protein ISOLATE, not just whey protein or whey powder. A 500g pot of whey protein isolate is a little costly but will last a long time and so is not a big expense long term. Note: I received some information early 2004 that suggested whey protein concentrate may have a higher amount of N-acetylneuraminic acid in it than the isolate.

How I can prepare and consume the ingredients:

TWO items will be discussed:

1. A glyconutrient powder which provides all 8 essential sugars at a minimal cost. The powder is more convenient to take and use than the "jam" and I am not currently using the "jam" -- just concentrating on the powder.
2. The glyconutrient jam which, if made correctly, tastes yummy and which is designed to give large amounts of the key monosaccharide mannose.

1. Glyconutrient Powder
Here are the powders, the glyconutrients they contain and the ratio for consumption (the ratio is by volume, not weight and is offered as a guide only):

• 1 part ground fenugreek: mannose, galactose (buy it already ground).
• 1 part shiitake mushroom powder: N-acetylglucosamine, mannose.
• 1 part kelp powder: fucose, xylose, mannose, galactose, and glucose.
• 1 part whey protein isolate: N-acetylneuraminic acid. Alternative is beer or brewing yeast.
• 1 part bovine or shark cartilage chondroitin sulphate powder (loose or in capsules): N-acetylglucosamine, N-acetylgalactosamine). Alternative is Dumontiaceae (www.dynamune.com/#RMA) for the N-acetylgalactosamine.
• 1/2 part of ground psyllium (or the husks alone would probably do) to boost the xylose content as there is not that much xylose in kelp.

I am currently mixing all powders together along with a little red cayenne pepper powder and a little turmeric powder too. I believe cayenne enhances my digestion and is an extra tonic (1/10-1/20th part). Turmeric has antioxidant properties.

I am also adding 1 part of lecithin granules as I have been told that this very greatly enhances absorption of glyconutrients.

I currently am mixing about 1 heaped tsp of the mixture in about 50-ml of cold soymilk and drinking it down quickly at the beginning of breakfast, lunch and sometimes also the evening meal. I would use more if I was ill with some major complaint.

Alternatively, I could take it with yogurt etc. or put the powder into "OO" size vegetable capsules to consume. Ideally, I would take five size "OO" capsules twice a day before meals. An alternative, if I wished to avoid mixing powders, would be to take one "OO" capsule of each powder twice a day before meals.

Thirdly, I could take my powder mixed with an equal amount of honey.

Notes:

It seems that some in Australia may be having difficulty tracking down some of these ingredients, which is a surprise. So as a service to Aussie folk and NZ researchers [go to http://www.burnoutsolutions.com.au/glycoaussie.htm] if you want some more tips. Also click on [the same] link for a suggestion I have found good regarding taste!

Whey protein isolate can be taken "sublingually" in small amounts too. I am told that this is an even better way of taking it. But it can take awhile to "dissolve".


 

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