Re: Thermerisol is toxic by Wyle E. Coyote ..... ADD/ADHD: Attention Deficit
Date: 10/10/2004 4:59:04 PM ( 21 y ago)
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URL: https://www.curezone.org/forums/fm.asp?i=51179
Here is a case report, which is not equivalent to an anecdote or testimonial, or a paretns observation, where the patient was exposed to a massive amount of thimerosal (correct spelling).
If it were as toxic as Miller-Miller whined about, he would not have survived unscathed.
J Toxicol Clin Toxicol. 1996;34(4):453-60. Related Articles, Links
Clinical course of severe poisoning with thiomersal.
Pfab R, Muckter H, Roider G, Zilker T.
Walther-Straub-Institut fur Pharmakologie und Toxikologie, Universitat Munchen, Germany.
CASE REPORT: A 44-year-old man ingested 83 mg/kg Thiomersal. He developed gastritis, renal tubular failure, dermatitis, gingivitis, delirium, coma, polyneuropathy and respiratory failure. Treatment was symptomatic plus gastric lavage and the oral chelating agents dimercaptopropane sulfonate and dimercaptosuccinic acid. The patient recovered completely. Maximum mercury concentrations were blood 14 mg/L, serum 1.7 mg/L, urine 10.7 mg/L, and cerebrospinal fluid 0.025 mg/L. Mercury concentration in blood declined with two velocities: first with half-time 2.2 days, then with half-time 40.5 days. The decline of mercury concentration in blood, urinary mercury excretion, and renal mercury clearance were not substantially influenced by chelation therapy.
Publication Types:
Case Reports
PMID: 8699562 [PubMed - indexed for MEDLINE]
Now, read this and attempt to understand it:
J Appl Toxicol. 2003 Jul-Aug;23(4):263-9. Related Articles, Links
Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants.
Magos L.
laszlomagos@aol.com
The decomposition rate of organomercurials and the potency of the blood-brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal the safety margin is increased even if the clearances were the same. However, the clearance half-time of ethylmercury in adults is about one-third of the 50 days' clearance half-time of methylmercury given for 60 kg body weight. Moreover, because metabolic rates (e.g. basal metabolism, daily loss of mercury in per cent of body burden) in different weight groups are related to the fractional power of body weight (rule of allometry), mercury clears from the infant body faster than from the adult body. Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations. Copyright 2003 John Wiley & Sons, Ltd.
Publication Types:
Review
Review, Tutorial
PMID: 12884410 [PubMed - indexed for MEDLINE]
I am aware of one study where infants cleared thimerosal so fast that it nearly blew the study.
Miller is old news, and not a scientific study.
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