Date:   10/27/2004 4:59:47 PM ( 20 y ago)
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Why Don’t Massive Doses of Ascorbate Produce Kidney Stones?


Years ago when Linus Pauling wrote his book "Vitamin C and the Common Cold", the critics immediately labeled the taking of large doses of vitamin C dangerous because it would produce calcium oxalate kidney stones. This practice of telling people that vitamin C caused kidney stones continues today by the critics of vitamin C despite the lack of clinical evidence of kidney stones in people taking vitamin C
It was hypothesized that since a significant percentage of ascorbate was metabolized into and excreted as oxalic acid that this oxalic acid should combine with calcium in the urine and deposit as calcium oxalate kidney stones. It is true that those of us who take large doses of ascorbate have elevated oxalic acid in our urine but no kidney stones. With the millions of people in the world taking vitamin C, if vitamin C caused kidney stones there would have been a massive epidemic of kidney stones noticed by this time. There has been none.
I started using vitamin C in massive doses in-patients in 1969. By the time I read that ascorbate should cause kidney stones, I had clinical evidence that it did n
ot cause kidney stones, so I continued prescribing massive doses to patients. To this day I estimate that I have put 25,000 patients on massive doses of vitamin C and none have developed kidney stones. Two patients who had dropped their doses to 500 mg a day developed calcium oxalate kidney stones. I raised their doses back up to the more massive doses and added magnesium and B6 to their program and no more kidney stones. I think that the low doses had no effect and they, by coincidence, developed the kidney stones because they were not taking enough vitamin C.
The question remains, however, why do not people taking large doses of ascorbate develop kidney stones. I had in 1985 hypothesized that one of the reasons that we did not develop kidney stones was that the ascorbate excreted in the urine sterilizes the urine and "should prevent many of the niduses of infection around which oxalate stones frequently form." (Cathcart, RF. Vitamin C: the Nontoxic, Nonrate-Limited, Antioxidant Free Radical Scavenger. Medical Hypotheses, 18:61-77, 1985.)
In an article in ScienceNewsOnline, August 1, 1998, the Bacteria in the Stone it is said that Extra-tiny microorganisms may lead to kidney stones and other diseases. Tiny nanobacteria, as small as the larger viruses, live in urine and, by precipitating calcium and other minerals around themselves, induce the formation of kidney stones. It seems that the large doses of ascorbate by causing the excretion of ascorbate in the urine probably kills the nanobacteria and prevents the formation of stones.
In addition, the massive doses of ascorbate assist the immune system to kill bacteria within the body but have the ability to kill bacteria by some mechanism, which does not seem to involve the immune system. These bacteria and L-forms of bacteria hide out in cells especially when Antibiotics are used and explain some of the resistance acquired by bacteria against Antibiotics . I have yet to see bacteria that can become resistant to massive doses of ascorbate in combination with first and second-generation Antibiotics . Admittedly in a private practice, I do not see the most resistant bacteria but this combination has been impressive and deserves to be tried against the most resistant bacteria. It may solve the impending problem of increasingly resistant bacteria.
See also the med center study indicating that even moderate doses of C prevent kidney stones.



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Why Don’t Massive Doses of Ascorbate Produce Kidney Stones?


Years ago when Linus Pauling wrote his book "Vitamin C and the Common Cold", the critics immediately labeled the taking of large doses of vitamin C dangerous because it would produce calcium oxalate kidney stones. This practice of telling people that vitamin C caused kidney stones continues today by the critics of vitamin C despite the lack of clinical evidence of kidney stones in people taking vitamin C
It was hypothesized that since a significant percentage of ascorbate was metabolized into and excreted as oxalic acid that this oxalic acid should combine with calcium in the urine and deposit as calcium oxalate kidney stones. It is true that those of us who take large doses of ascorbate have elevated oxalic acid in our urine but no kidney stones. With the millions of people in the world taking vitamin C, if vitamin C caused kidney stones there would have been a massive epidemic of kidney stones noticed by this time. There has been none.
I started using vitamin C in massive doses in-patients in 1969. By the time I read that ascorbate should cause kidney stones, I had clinical evidence that it did n
ot cause kidney stones, so I continued prescribing massive doses to patients. To this day I estimate that I have put 25,000 patients on massive doses of vitamin C and none have developed kidney stones. Two patients who had dropped their doses to 500 mg a day developed calcium oxalate kidney stones. I raised their doses back up to the more massive doses and added magnesium and B6 to their program and no more kidney stones. I think that the low doses had no effect and they, by coincidence, developed the kidney stones because they were not taking enough vitamin C.
The question remains, however, why do not people taking large doses of ascorbate develop kidney stones. I had in 1985 hypothesized that one of the reasons that we did not develop kidney stones was that the ascorbate excreted in the urine sterilizes the urine and "should prevent many of the niduses of infection around which oxalate stones frequently form." (Cathcart, RF. Vitamin C: the Nontoxic, Nonrate-Limited, Antioxidant Free Radical Scavenger. Medical Hypotheses, 18:61-77, 1985.)
In an article in ScienceNewsOnline, August 1, 1998, the Bacteria in the Stone it is said that Extra-tiny microorganisms may lead to kidney stones and other diseases. Tiny nanobacteria, as small as the larger viruses, live in urine and, by precipitating calcium and other minerals around themselves, induce the formation of kidney stones. It seems that the large doses of ascorbate by causing the excretion of ascorbate in the urine probably kills the nanobacteria and prevents the formation of stones.
In addition, the massive doses of ascorbate assist the immune system to kill bacteria within the body but have the ability to kill bacteria by some mechanism, which does not seem to involve the immune system. These bacteria and L-forms of bacteria hide out in cells especially when antibiotics are used and explain some of the resistance acquired by bacteria against antibiotics. I have yet to see bacteria that can become resistant to massive doses of ascorbate in combination with first and second-generation antibiotics. Admittedly in a private practice, I do not see the most resistant bacteria but this combination has been impressive and deserves to be tried against the most resistant bacteria. It may solve the impending problem of increasingly resistant bacteria.
See also the med center study indicating that even moderate doses of C prevent kidney stones.

A prospective study of the intake of Vitamins C and B6, and the risk of
kidney stones in men.

Other references on nanobacteria kidney stones, and other calcium deposites about the body like arteriosclerosis:

Nanobacteria May Be Bacterial Cause Of Kidney Stones
The Bacteria and the Stone More information about Nanobacterium sanquineum

A prospective study of the intake of Vitamins C and B6, and the risk of kidney stones in men.

http://www.hnet.net/~dlnj/fischercritique.htm
http://www.uku.fi/~kajander/

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