Date:   2/6/2006 11:21:27 AM ( 18 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=358627

Authors Marrades RM. Roca J. Barbera JA. Dejover L. Macnee W. Rodriguezroisin R.
Title NEBULIZED GLUTATHIONE INDUCES BRONCHOCONSTRICTION IN PATIENTS WITH MILD ASTHMA
Source American Journal of Respiratory & Critical Care Medicine. 156(2):425-430, 1997 Aug.

Abstract To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of
the most efficient scavengers of oxidant substances in the airways, we
studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in
a randomized, double-blind, cross-over, placebo-controlled fashion.
Bronchial challenge was measured using both FEV1 and total pulmonary
resistance (Rrs) by the forced oscillation technique. Patients received
nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo
(identical saline solution) over a period of 25 min, 1 wk apart. Placebo
provoked subclinical mild bronchoconstriction (changes from baseline: FEV1,
-1%; Rrs, +17%); by contrast, GSH caused major airway narrowing (changes
from baseline: FEV1, -19%; Rrs, +61%) and induced cough (four patients) or
breathlessness (three patients). Differences between placebo and GSH after
challenge were also noticeable in both FEV1 (p = 0.03) and Rrs (p = 0.02).
Neither osmolarity (660 mosm . kg(-1)) nor pH (3.0) of the GSH solution
accounted for these effects. Nebulized salbutamol (5.0 mg) given before the
GSH challenge blocked GSH-induced bronchoconstriction. Furthermore,
GSH-induced FEV1 falls were inversely correlated with metabisulfite
bronchoprovocation (provocative dose [PD20], 1.49 +/- 1.83 mu mol) but not
with methacholine challenge. The detrimental effects of nebulized GSH on the
airway bronchial tone in patients with mild asthma strongly suggests
bronchoconstriction provoked by sulfite formation. [References: 29]
Publication Type Article

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