Date:   6/21/2014 1:54:32 PM ( 10 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=2182431

James,
More potent than Iodine is Gentian Violet. It was used internally many years ago, but recent studies have linked it to cancer, even when some of them contradictory. There are old reports of successful uses of Gentian Violet tablets to cure chronic intestinal candidiasis. Contrary to Iodine, Gentian Violet is fungicidal and has affinity for damaged tissues. It is probably the best antifungal agent but we can not take it internally after knowing those reports linking it to cancer.
There are antifungal combinations more potent than Iodine. The Iodine concentration you can take internally is too weak to eradicate the fungus.
Jorge
Fungicidal Gentian Violet Most Potent and Least Expensive Topical Agent for HIV-Infected Patients
: Presented at IDSA
Tags: AIDS and HIV chlorhexidine fluconazole nystatin
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By Kristina R. Anderson

SAN DIEGO, CA -- October 9, 2007 -- In a comparison study of various agents used commonly for treatment of candidiasis of the mouth in patients with HIV, gentian violet led the pack as the most potent of the inexpensive alternatives.

Previously, studies comparing the inexpensive alternatives against the pricier fluconazole and nystatin for treatment of oral thrush in HIV populations have been lacking, but researchers have now conducted research on the use of gentian violet to treat candidiasis of the mouth.

The researchers compared various agents -- gentian violet, melaleuca, chlorhexidine, and povidone Iodine -- against fluconazole.

Lead author Rana Traboulsi, MD, Researcher, Center for Medical Mycology, Case Western Reserve University, and Oral HIV/AIDS Research Alliance, Cleveland, Ohio, who wrote the protocol, presented the study findings in a poster on October 5 here at the Infectious Diseases Society of America (IDSA) 45th Annual Meeting.

The head-to-head study was an in vitro comparison of the antifungal activity of gentian violet, melaleuca, povidone iodine, and chlorhexidine against Candida isolates swabbed from the oral cavity of AIDS patients, providing rationale for selecting the most potent compound that will next be evaluated in a clinical trial.

Gentian violet, which has a long history of safe use, was shown to exhibit the most potent activity against all Candida isolates tested; but unlike the other contenders, it had fungicidal activity and was effective against even the fluconazole-resistant strains.

"We did a review of the literature and didn't see anything being used in Africa except on a random basis," said Dr. Traboulsi, who added that she was in the process of submitting her group's findings to a peer-reviewed infectious disease journal.

A summary of the study's findings on gentian violet includes:

· Gentian violet is the most potent inexpensive topical alternative agent tested.

· It proved efficacious as a fungicidal against all C. albicans species tested, including the fluconazole-resistant Candida isolates.

· In vitro combination testing of GV and FLC showed no antagonistic interaction between the compounds.

· Gentian violet may have utility as an adjunct therapy for the treatment and prophylaxis of oropharyngeal candidiasis, a complication that develops in virtually every patient with AIDS.

Oral thrush can cause significant discomfort, pain, and even morbidity among HIV patients in resource-constrained communities; however, fluconazole and oral nystatin are both relatively expensive.

Dr. Traboulsi said that her research group is putting together the protocol for a clinical trial of gentian violet. "This is an inexpensive agent that can be used extensively in Africa, where they cannot afford typical antifungal drugs."

ABSTRACT

The effect of gentian violet against Candida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.
 

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