Date:   3/13/2013 4:22:36 PM ( 11 y ago)
Hits:   1,443
URL:   https://www.curezone.org/forums/fm.asp?i=2045316

Will anything change now that cutting-edge techniques have provided support for the conclusions of Andrew Wakefield's controversial 1998 Lancet case series?


Case series confirmed...................
Science doesn't exist in a vacuum: if a piece of research into an active area of scientific enquiry is valid, sooner or later it will be repeated or otherwise confirmed by other researchers. To listen to any of Andrew Wakefield's many detractors, one would think that no scientific evidence has emerged since 1998 in support of his supposedly fraudulent case series, retracted by the Lancet in 2010. But that's simply not true, as has been pointed out before, not least by Wakefield himself in his second book, Waging War on the Autistic Child [1]. This week, open-access journal PLOS One has published data that powerfully confirm Wakefield et al's original results.

From macro to micro.................
The 1998 Lancet paper was a case series reporting observations of a group of children who presented with similar symptoms. The 2013 research published in PLOS One, by contrast, harnessed sophisticated laboratory techniques, but toward a similar goal: to focus in on the molecular changes occurring in the intestinal cells of children with ASD and inflammation of the small (ileitis) or large (colitis) bowel, or both. Importantly, the new study not only compared the intestinal molecular profiles of ASD children with those of healthy, control children; it also compared them with changes occurring in the bowels of children with the inflammatory bowel conditions Crohn's disease (CD) and ulcerative colitis (UC). If the changes observed in ASD children were distinct from those of the CD and UC children, it would validate Wakefield's 1998 finding of a novel syndrome in ASD children.


How did they do it?..................
Six children with autism and a further 19 with ASD were included in the study, all of whom had confirmed diagnoses of ileitis, colitis or both. Cells were taken from the small and large bowel of these children, and the samples were subjected to microarray analysis – a technique that assesses the gene expression profiles of the samples. The result is a small glass slide or silicon chip containing information on all of the myriad genes that are turned on or off in the sample: a true snapshot of the molecular processes occurring in the cells. An identical procedure was used on samples from eight non-autistic and non-ASD children with CD, five non-autistic/non-ASD children with UC and 15 healthy controls....................more, much more...............

http://anh-europe.org/news/was-andrew-wakefield-right-all-along?utm_source=Th...

 

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